DK174941B1 - DNA-fragment kodende for lysostaphin, rekombinante plasmider indeholdende dette, tranformerede mikroorganismer samt ekspession af det klonede lysostaphin - Google Patents

DNA-fragment kodende for lysostaphin, rekombinante plasmider indeholdende dette, tranformerede mikroorganismer samt ekspession af det klonede lysostaphin Download PDF

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Publication number
DK174941B1
DK174941B1 DK198706592A DK659287A DK174941B1 DK 174941 B1 DK174941 B1 DK 174941B1 DK 198706592 A DK198706592 A DK 198706592A DK 659287 A DK659287 A DK 659287A DK 174941 B1 DK174941 B1 DK 174941B1
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Prior art keywords
lysostaphin
transformed
dna fragment
bacillus
dna
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Application number
DK198706592A
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Danish (da)
English (en)
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DK659287A (da
DK659287D0 (da
Inventor
Paul A Recsei
Original Assignee
Ambi Inc
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Publication date
Application filed by Ambi Inc filed Critical Ambi Inc
Publication of DK659287A publication Critical patent/DK659287A/da
Publication of DK659287D0 publication Critical patent/DK659287D0/da
Application granted granted Critical
Publication of DK174941B1 publication Critical patent/DK174941B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK198706592A 1986-04-16 1987-12-15 DNA-fragment kodende for lysostaphin, rekombinante plasmider indeholdende dette, tranformerede mikroorganismer samt ekspession af det klonede lysostaphin DK174941B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85240786A 1986-04-16 1986-04-16
US85240786 1986-04-16
US07/034,464 US4931390A (en) 1986-04-16 1987-04-10 Expression of the cloned lysostaphin gene
US3446487 1987-04-10
US8700873 1987-04-15
PCT/US1987/000873 WO1987006264A1 (en) 1986-04-16 1987-04-15 Expression of the cloned lysostaphin gene

Publications (3)

Publication Number Publication Date
DK659287A DK659287A (da) 1987-12-15
DK659287D0 DK659287D0 (da) 1987-12-15
DK174941B1 true DK174941B1 (da) 2004-03-08

Family

ID=26710985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198706592A DK174941B1 (da) 1986-04-16 1987-12-15 DNA-fragment kodende for lysostaphin, rekombinante plasmider indeholdende dette, tranformerede mikroorganismer samt ekspession af det klonede lysostaphin

Country Status (15)

Country Link
US (1) US4931390A (ja)
EP (1) EP0299978B1 (ja)
JP (1) JP2963695B2 (ja)
AT (1) ATE92524T1 (ja)
AU (1) AU616379B2 (ja)
CA (1) CA1297051C (ja)
DE (1) DE3786918T2 (ja)
DK (1) DK174941B1 (ja)
FI (1) FI96322C (ja)
HU (1) HU205386B (ja)
IE (1) IE60769B1 (ja)
IL (1) IL82260A (ja)
NZ (1) NZ219998A (ja)
PT (1) PT84705B (ja)
WO (1) WO1987006264A1 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260212A (en) * 1987-02-09 1993-11-09 Quest International Flavors & Food Ingredients Co., Division Of Indopco Cloned gene encoding for bacteriocin from Pediococcus acidilactici
US5858962A (en) * 1987-05-11 1999-01-12 Ambi Inc. Composition for treating mastitis and other staphylococcal infections
US5011772A (en) * 1988-02-05 1991-04-30 Public Health Research Institute Of The City Of N.Y. High yield protein production system
EP0370103A4 (en) * 1988-05-05 1991-11-27 Health Res Inst City New York Protease-deficient gram-positive bacteria and their use as host organisms for the production of recombinant products
CA2009336A1 (en) * 1989-07-03 1991-01-03 Peter A. Vandenbergh Cloned gene encoding for bacteriocin from pediococcus acidilactici
DE4425645A1 (de) * 1994-07-20 1996-02-22 Mueller Karl & Co Kg Deletiertes Lysostaphingen von Staphylococcus simulans
NZ311535A (en) * 1995-06-23 2001-05-25 Ambi Inc A method for the control of antibiotic-resistant gram positive bacteria and treatment of infection
WO1997008553A1 (en) * 1995-08-22 1997-03-06 The Regents Of The University Of California Targeting of proteins to the cell wall of gram-positive bacteria
US5910479A (en) * 1996-10-18 1999-06-08 Ambi Inc. Method for the treatment of Streptococcus pneumoniae infection
US6028051A (en) * 1997-07-23 2000-02-22 Ambi Inc. Method for the treatment of staphylococcal disease
US6875903B2 (en) * 1998-06-22 2005-04-05 University Of Vermont Treatment of Staphylococcus infections
US7091332B1 (en) 1998-06-22 2006-08-15 University Of Vermont Treatment of staphylococcus infections
AU4706799A (en) * 1998-06-22 2000-01-10 University Of Vermont And State Agricultural College, The Treatment of (staphylococcus) infections
JP4416866B2 (ja) * 1998-07-30 2010-02-17 オリエンタル酵母工業株式会社 カルシウム測定用液状試薬
US6569830B1 (en) 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
CN1267551C (zh) * 1999-10-19 2006-08-02 印度生物技术国际有限公司 重组成熟溶葡萄球菌素的表达
ATE516356T1 (de) * 2001-12-21 2011-07-15 Biosynexus Inc Gestutzes lysostaphin-molekül mit verbesserter staphylolytischer wirkung
JP2005528372A (ja) * 2002-03-26 2005-09-22 バイオシネクサス インコーポレイテッド 抗菌ポリマー複合体
CN1642496A (zh) * 2002-03-26 2005-07-20 拜奥辛尼克休斯公司 细菌生物薄膜的酶破坏
US20100221237A1 (en) * 2003-03-26 2010-09-02 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
EP1988104B1 (en) 2003-03-28 2010-03-03 Mitsui Chemicals, Inc. Propylene copolymer, polypropylene composition, use thereof, transition metal compounds, and catalysts for olefin polymerization
CN100485031C (zh) * 2004-09-02 2009-05-06 上海高科联合生物技术研发有限公司 一种溶葡萄球菌酶工业化纯化工艺
EP1885403B1 (en) 2005-04-12 2013-05-08 Nektar Therapeutics Poly(ethyleneglycol) conjugates of Lysostaphin
CN100475965C (zh) * 2005-07-22 2009-04-08 上海高科联合生物技术研发有限公司 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法
US20080095756A1 (en) * 2006-09-05 2008-04-24 Biosynexus Incorporated Compositions Comprising Lysostaphin Variants And Methods Of Using The Same
EP2179052B1 (en) * 2007-07-09 2012-11-14 Microsens Medtech Ltd Detection of micro-organisms based on their nad-dependent dna ligase activity
US20110044968A1 (en) * 2008-03-10 2011-02-24 Pharmal N Corporation Compositions for treatment with metallopeptidases, methods of making and using the same
WO2012050787A1 (en) 2010-09-29 2012-04-19 Ibis Biosciences, Inc. Fungal nucleic acid extraction
CN113717964A (zh) * 2013-08-06 2021-11-30 达特茅斯学院理事会 非糖基化溶葡球菌素变体蛋白
US9814766B2 (en) 2013-12-28 2017-11-14 Longhorn Vaccines And Diagnostics, Llc Multimodal antimicrobial therapy
CA2948864C (en) 2014-05-14 2023-10-17 Karl E. Griswold Deimmunized lysostaphin and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278378A (en) * 1962-04-19 1966-10-11 Schindler Charles Alvin Staphylococcus-derived antibiotic
US4467036A (en) * 1981-11-12 1984-08-21 The Board Of Regents Of The University Of Washington Bacillus thuringiensis crystal protein in Escherichia coli
US4617266A (en) * 1983-04-28 1986-10-14 Genex Corporation Production of Protein A

Also Published As

Publication number Publication date
JP2963695B2 (ja) 1999-10-18
IE60769B1 (en) 1994-08-10
US4931390A (en) 1990-06-05
FI884691A0 (fi) 1988-10-12
DE3786918T2 (de) 1993-11-11
NZ219998A (en) 1991-05-28
FI884691A (fi) 1988-10-12
IE870980L (en) 1987-10-16
WO1987006264A1 (en) 1987-10-22
EP0299978B1 (en) 1993-08-04
ATE92524T1 (de) 1993-08-15
IL82260A (en) 1992-08-18
AU7302187A (en) 1987-11-09
HU205386B (en) 1992-04-28
FI96322B (fi) 1996-02-29
PT84705A (en) 1987-05-01
FI96322C (fi) 1996-06-10
IL82260A0 (en) 1987-10-30
AU616379B2 (en) 1991-10-31
DE3786918D1 (de) 1993-09-09
EP0299978A1 (en) 1989-01-25
HUT50874A (en) 1990-03-28
CA1297051C (en) 1992-03-10
DK659287A (da) 1987-12-15
DK659287D0 (da) 1987-12-15
PT84705B (pt) 1989-11-30
JPH01503036A (ja) 1989-10-19

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