DK174496B1 - Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre - Google Patents

Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre Download PDF

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Publication number
DK174496B1
DK174496B1 DK198605882A DK588286A DK174496B1 DK 174496 B1 DK174496 B1 DK 174496B1 DK 198605882 A DK198605882 A DK 198605882A DK 588286 A DK588286 A DK 588286A DK 174496 B1 DK174496 B1 DK 174496B1
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DK
Denmark
Prior art keywords
dimethylphenoxy
parts
toluene
alkali metal
bromo
Prior art date
Application number
DK198605882A
Other languages
Danish (da)
English (en)
Other versions
DK588286D0 (da
DK588286A (da
Inventor
Francis R Kearney
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK588286D0 publication Critical patent/DK588286D0/da
Publication of DK588286A publication Critical patent/DK588286A/da
Application granted granted Critical
Publication of DK174496B1 publication Critical patent/DK174496B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK198605882A 1985-12-09 1986-12-08 Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre DK174496B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/806,312 US4665226A (en) 1985-12-09 1985-12-09 Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
US80631285 1985-12-09

Publications (3)

Publication Number Publication Date
DK588286D0 DK588286D0 (da) 1986-12-08
DK588286A DK588286A (da) 1987-06-10
DK174496B1 true DK174496B1 (da) 2003-04-22

Family

ID=25193782

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198605882A DK174496B1 (da) 1985-12-09 1986-12-08 Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre

Country Status (22)

Country Link
US (1) US4665226A (xx)
EP (1) EP0226161B1 (xx)
JP (1) JP2506094B2 (xx)
KR (2) KR870005954A (xx)
CN (1) CN1012896B (xx)
AT (1) ATE47832T1 (xx)
AU (1) AU590358B2 (xx)
CA (1) CA1267155A (xx)
DE (1) DE3666805D1 (xx)
DK (1) DK174496B1 (xx)
ES (1) ES2011245B3 (xx)
FI (1) FI85974C (xx)
GR (1) GR3000216T3 (xx)
HK (1) HK112193A (xx)
HU (1) HU195635B (xx)
IE (1) IE59499B1 (xx)
IL (1) IL80885A (xx)
IN (1) IN166169B (xx)
NO (1) NO164293C (xx)
PH (1) PH24273A (xx)
PT (1) PT83888B (xx)
ZA (1) ZA868893B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU205891B (en) * 1990-05-11 1992-07-28 Gyogyszerkutato Intezet Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid
US5235097A (en) * 1990-05-11 1993-08-10 Egis Gyogyszergyar Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates
US5041640A (en) * 1990-09-20 1991-08-20 Warner-Lambert Company Process for mono-, di-, trisubstituted acetic acids
BE1007058A3 (fr) * 1992-06-16 1995-03-07 Omnichem Sa Un procede nouveau pour la preparation de l'acide 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoique.
IT1265087B1 (it) * 1993-05-20 1996-10-30 Recordati Chem Pharm Processo per la preparazione di gemfibrozil
US5412112A (en) * 1994-06-14 1995-05-02 Industrial Technology Research Institute Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids
US5530145A (en) * 1994-06-14 1996-06-25 Syn-Tech Chem & Pharm Co., Ltd. Anticholesteremic compounds
JP2006510349A (ja) * 2002-08-08 2006-03-30 スミスクライン・ビーチャム・コーポレイション アンサミトシンの単離および精製方法
CN101440032B (zh) * 2008-11-13 2012-05-23 浙江大学 一种吉非罗齐的多晶型及其制备方法
WO2020212955A1 (en) * 2019-04-18 2020-10-22 Hikal Limited Process for the preparation of a key intermediate of gemfibrozil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3707566A (en) * 1970-03-30 1972-12-26 Parke Davis & Co Aryloxypentane compounds
US3759986A (en) * 1970-03-30 1973-09-18 Parke Davis & Co Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols
GB1422679A (en) * 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
GB2025942A (en) * 1978-05-31 1980-01-30 Sori Soc Rech Ind Phenoxyalkylcarboxylic acids
DK305884A (da) * 1983-06-24 1984-12-25 Yamanouchi Pharma Co Ltd Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat

Also Published As

Publication number Publication date
IL80885A0 (en) 1987-03-31
NO864933D0 (no) 1986-12-08
AU590358B2 (en) 1989-11-02
AU6560686A (en) 1987-06-11
JPS62138447A (ja) 1987-06-22
JP2506094B2 (ja) 1996-06-12
ZA868893B (en) 1988-07-27
IL80885A (en) 1991-04-15
ES2011245B3 (es) 1990-01-01
NO864933L (no) 1987-06-10
PT83888A (en) 1987-01-01
KR870005954A (ko) 1987-07-08
EP0226161A1 (en) 1987-06-24
IE59499B1 (en) 1994-03-09
HK112193A (en) 1993-10-29
DE3666805D1 (en) 1989-12-14
IE863060L (en) 1987-06-09
DK588286D0 (da) 1986-12-08
FI864900A0 (fi) 1986-12-01
FI85974C (fi) 1992-06-25
IN166169B (xx) 1990-03-24
GR3000216T3 (en) 1990-12-31
NO164293C (no) 1990-09-19
HU195635B (en) 1988-06-28
PT83888B (pt) 1989-05-12
ATE47832T1 (de) 1989-11-15
PH24273A (en) 1990-05-29
US4665226A (en) 1987-05-12
NO164293B (no) 1990-06-11
DK588286A (da) 1987-06-10
HUT43024A (en) 1987-09-28
FI85974B (fi) 1992-03-13
EP0226161B1 (en) 1989-11-08
CN1012896B (zh) 1991-06-19
KR950003120B1 (ko) 1995-04-01
CA1267155A (en) 1990-03-27
FI864900A (fi) 1987-06-10
CN86108472A (zh) 1987-07-22

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