DK174284B1 - Biologisk aktive tetrasaccharider - Google Patents

Biologisk aktive tetrasaccharider Download PDF

Info

Publication number
DK174284B1
DK174284B1 DK198502159A DK215985A DK174284B1 DK 174284 B1 DK174284 B1 DK 174284B1 DK 198502159 A DK198502159 A DK 198502159A DK 215985 A DK215985 A DK 215985A DK 174284 B1 DK174284 B1 DK 174284B1
Authority
DK
Denmark
Prior art keywords
groups
group
tetrasaccharides
reaction
sulfate
Prior art date
Application number
DK198502159A
Other languages
Danish (da)
English (en)
Other versions
DK215985D0 (da
DK215985A (da
Inventor
Maurice Petitou
Jean-Claude Lormeau
Jean Choay
Jean-Claude Jacquinet
Pierre Sinay
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of DK215985D0 publication Critical patent/DK215985D0/da
Publication of DK215985A publication Critical patent/DK215985A/da
Application granted granted Critical
Publication of DK174284B1 publication Critical patent/DK174284B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK198502159A 1984-05-16 1985-05-15 Biologisk aktive tetrasaccharider DK174284B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8407589 1984-05-16
FR8407589A FR2564468B1 (fr) 1984-05-16 1984-05-16 Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques

Publications (3)

Publication Number Publication Date
DK215985D0 DK215985D0 (da) 1985-05-15
DK215985A DK215985A (da) 1985-11-17
DK174284B1 true DK174284B1 (da) 2002-11-11

Family

ID=9304040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502159A DK174284B1 (da) 1984-05-16 1985-05-15 Biologisk aktive tetrasaccharider

Country Status (11)

Country Link
EP (1) EP0165134B1 (de)
JP (1) JPH07108911B2 (de)
AT (1) ATE85341T1 (de)
AU (1) AU582362B2 (de)
CA (1) CA1265792A (de)
DE (1) DE3587051T2 (de)
DK (1) DK174284B1 (de)
FR (1) FR2564468B1 (de)
IE (1) IE59101B1 (de)
NZ (1) NZ212094A (de)
ZA (1) ZA853694B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
EP0300099A1 (de) * 1987-07-20 1989-01-25 Akzo N.V. Pentasaccharide
FR2718849B1 (fr) * 1994-04-14 1996-06-14 Pasteur Sanofi Diagnostics Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention.
CA2199642C (en) * 1997-03-10 2001-05-08 Roger Cariou Compositions containing an association of aspirin and an anti-xa oligosaccharide and use of an anti-xa oligosaccharide optionally in combination with aspirin
AUPO556297A0 (en) 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
AUPO976897A0 (en) * 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
ES2423888T3 (es) 2001-09-07 2013-09-25 Alchemia Limited Pentasacáridos de heparina sintéticos
WO2009155108A1 (en) 2008-05-30 2009-12-23 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
EP2256137A1 (de) * 2009-05-05 2010-12-01 Sanofi-Aventis Neuartiges sulfiertes Octasaccharid und dessen Verwendung als Antithrombotikum
EP2256136A1 (de) * 2009-05-05 2010-12-01 Sanofi-Aventis Neuartigeacyliertes Decasaccharid und dessen Verwendung als Antithrombotikum
EP2256138A1 (de) * 2009-05-05 2010-12-01 Sanofi-Aventis Neues acyliertes 1,6-anhydrodecasacharid und seine Verwendung als antithrombitisches Mittel
EP2255817A1 (de) * 2009-05-05 2010-12-01 Sanofi-Aventis Verwendung eines acylierten Octasaccharids als Antithrombotikum
EP2256139A1 (de) * 2009-05-05 2010-12-01 Sanofi-Aventis Neuartiges sulfiertes Octasaccharid und dessen Verwendung als Antithrombotikum
CN103145774A (zh) * 2013-03-21 2013-06-12 苏州鸿洋医药科技有限公司 一种抗凝戊糖及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098995A (en) * 1976-07-12 1978-07-04 American Cyanamid Company Polygalactosido-sucrose poly(h-)sulfate salts
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
FR2519987A1 (fr) * 1982-01-15 1983-07-22 Choay Sa Trisaccharides a structures d-glucosamine, acide d-glucuronique, d-glucosamine et leur preparation
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
SE8301609D0 (sv) * 1983-03-23 1983-03-23 Svenska Sockerfabriks Ab Forening och komposition for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutisk behandling

Also Published As

Publication number Publication date
EP0165134B1 (de) 1993-02-03
NZ212094A (en) 1988-11-29
ZA853694B (en) 1986-01-29
DK215985D0 (da) 1985-05-15
FR2564468A2 (fr) 1985-11-22
DE3587051D1 (de) 1993-03-18
FR2564468B1 (fr) 1994-12-23
EP0165134A2 (de) 1985-12-18
JPS60260590A (ja) 1985-12-23
DE3587051T2 (de) 1993-08-19
AU582362B2 (en) 1989-03-23
IE851214L (en) 1985-11-16
AU4263785A (en) 1985-11-21
JPH07108911B2 (ja) 1995-11-22
EP0165134A3 (en) 1988-02-24
CA1265792A (fr) 1990-02-13
IE59101B1 (en) 1994-01-12
ATE85341T1 (de) 1993-02-15
DK215985A (da) 1985-11-17

Similar Documents

Publication Publication Date Title
JP2510925B2 (ja) ガラクトサミン−ウロン酸基本(モチ―フ)を含むオリゴ糖類及びそれらの生物学的用途
AU634199B2 (en) Heparin fragments as inhibitors of smooth muscle cell proliferation
US5380716A (en) Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
US4990502A (en) Low molecular weight heparins of regular structure, their preparation and their biological uses.
US5013724A (en) Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
US4818816A (en) Process for the organic synthesis of oligosaccharides and derivatives thereof
US4801583A (en) Oligosaccharides and their biological applications
DK174284B1 (da) Biologisk aktive tetrasaccharider
HU215152B (hu) Eljárás pentaszacharid egységet tartalmazó szénhidrátszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
NO179452B (no) Sulfaterte glukosamin-glukanoid-derivater
WO1992002232A1 (en) Heparin fragment showing complement inhibition activity
KR101223364B1 (ko) 비오틴화 16당류, 그의 제조 방법 및 그의 용도
KR100324583B1 (ko) 3-데옥시올리고사카라이드,상기화합물을제조하는방법및상기화합물을함유하는약제학적조성물
WO1992018546A1 (en) Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
KR20010034205A (ko) 신규한 오당류, 이의 제조방법 및 이를 함유하는 제약조성물
EP1694714B1 (de) Niedermolekulare polysaccharide mit antithrombotischer wirkung
MXPA04012721A (es) Proceso para la fabricacion de derivados de n-acil-(epi)k5-amina-o-sulfato y productos obtenidos de esta forma.
DK174348B1 (da) Pentasaccharider, tetrasaccharider og mellemprodukter i form af pentasaccharider, tetrasaccharider og disaccharider til fremstilling af pentasaccharider, samt fremgangsmåde til fremstilling af pentasaccharider
RU2333222C2 (ru) Эпимеризованные производные полисахарида к5 с высокой степенью сульфатирования
EP2721044B1 (de) Synthetische pentasaccharide mit kurzer halbwertszeit und hoher aktivität
JP2000256385A (ja) オリゴ糖の製造方法ならびに新規オリゴ糖およびそれを含む医薬組成物
JPH11166001A (ja) 過硫酸化コンドロイチン硫酸、その製造方法及びそれを有効成分として含有する抗血液凝固剤

Legal Events

Date Code Title Description
PUP Patent expired