DK174066B1 - Fremgangsmåde til fremstilling af et faktor VIII-præparat - Google Patents
Fremgangsmåde til fremstilling af et faktor VIII-præparat Download PDFInfo
- Publication number
- DK174066B1 DK174066B1 DK198503981A DK398185A DK174066B1 DK 174066 B1 DK174066 B1 DK 174066B1 DK 198503981 A DK198503981 A DK 198503981A DK 398185 A DK398185 A DK 398185A DK 174066 B1 DK174066 B1 DK 174066B1
- Authority
- DK
- Denmark
- Prior art keywords
- viii
- solution
- per
- factor viii
- preparation
- Prior art date
Links
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229960000301 factor viii Drugs 0.000 title claims abstract description 11
- 108010054218 Factor VIII Proteins 0.000 title claims description 10
- 102000001690 Factor VIII Human genes 0.000 title claims description 10
- 239000000243 solution Substances 0.000 claims description 32
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 18
- 150000002500 ions Chemical class 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
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- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 108010035369 Cohn fraction I Proteins 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
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- 108091005804 Peptidases Proteins 0.000 description 1
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- 108010000499 Thromboplastin Proteins 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
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- 208000009429 hemophilia B Diseases 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 229940106780 human fibrinogen Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Conductive Materials (AREA)
- Glass Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3432083 | 1984-08-31 | ||
| DE19843432083 DE3432083A1 (de) | 1984-08-31 | 1984-08-31 | Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK398185D0 DK398185D0 (da) | 1985-08-30 |
| DK398185A DK398185A (da) | 1986-03-01 |
| DK174066B1 true DK174066B1 (da) | 2002-05-21 |
Family
ID=6244387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198503981A DK174066B1 (da) | 1984-08-31 | 1985-08-30 | Fremgangsmåde til fremstilling af et faktor VIII-præparat |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0173242B2 (enrdf_load_stackoverflow) |
| JP (1) | JPS6160614A (enrdf_load_stackoverflow) |
| AT (1) | ATE73666T1 (enrdf_load_stackoverflow) |
| CA (1) | CA1265051A (enrdf_load_stackoverflow) |
| DE (2) | DE3432083A1 (enrdf_load_stackoverflow) |
| DK (1) | DK174066B1 (enrdf_load_stackoverflow) |
| ES (1) | ES8702146A1 (enrdf_load_stackoverflow) |
| IL (1) | IL76260A (enrdf_load_stackoverflow) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743680A (en) * | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
| US4847362A (en) * | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
| US4952675A (en) * | 1985-02-01 | 1990-08-28 | New York University | Method for purifying antihemophilic factor |
| CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
| DE3878227D1 (de) * | 1988-05-27 | 1993-03-18 | Centre Regional De Transfusion | Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie. |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| ES2053684T3 (es) * | 1988-11-05 | 1994-08-01 | Octapharma Ag | Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia. |
| DE3926034C3 (de) * | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
| DE4001451A1 (de) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| DE4143678B4 (de) * | 1991-02-27 | 2005-03-10 | Holland Letz Felo Werkzeug | Halter für Schraubendreher-Einsätze |
| AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
| FR2681867B1 (fr) | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
| AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
| AU6653094A (en) * | 1992-12-16 | 1994-07-04 | Immuno Aktiengesellschaft | Process for preparing a virus-safe biological composition |
| DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
| DE4337573C1 (de) * | 1993-11-04 | 1995-05-18 | Octapharma Ag | Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden |
| DE19802007C1 (de) * | 1998-01-20 | 1999-11-11 | Wacker Werke Kg | Sicherheitsanordnung für die Bedienungselemente einer handgeführten Bodenverdichtungswalze |
| DE102004009400A1 (de) | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
| CN102295696B (zh) * | 2011-08-16 | 2013-06-26 | 山东泰邦生物制品有限公司 | 由冷沉淀制备凝血因子ⅷ、纤维蛋白原和纤维结合蛋白的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2653534C2 (de) * | 1975-12-22 | 1986-08-28 | Baxter Travenol Laboratories, Inc., Deerfield, Ill. | Feste Antihämophilen-Faktor-Präparation und Verfahren zu ihrer Herstellung |
| DE2635894A1 (de) * | 1976-08-10 | 1978-02-16 | Biotest Serum Institut Gmbh | Verfahren zur herstellung eines antihaemophiles globulin a enthaltenden konzentrats |
| JPS57136526A (en) * | 1981-02-17 | 1982-08-23 | Green Cross Corp:The | Preparation of blood coagulation factor 8 |
| AU555305B2 (en) * | 1982-09-29 | 1986-09-18 | Bayer Corporation | Antihemophilic factor concentrate |
| DE3237512A1 (de) * | 1982-10-09 | 1984-04-12 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat |
| US4508709A (en) * | 1983-12-05 | 1985-04-02 | Armour Pharmaceutical Company | Process for purifying factor VIII:C |
-
1984
- 1984-08-31 DE DE19843432083 patent/DE3432083A1/de not_active Withdrawn
-
1985
- 1985-08-21 AT AT85110499T patent/ATE73666T1/de not_active IP Right Cessation
- 1985-08-21 EP EP85110499A patent/EP0173242B2/de not_active Expired - Lifetime
- 1985-08-21 DE DE8585110499T patent/DE3585649D1/de not_active Expired - Lifetime
- 1985-08-29 ES ES546526A patent/ES8702146A1/es not_active Expired
- 1985-08-30 IL IL76260A patent/IL76260A/xx not_active IP Right Cessation
- 1985-08-30 DK DK198503981A patent/DK174066B1/da not_active IP Right Cessation
- 1985-08-30 CA CA000489738A patent/CA1265051A/en not_active Expired - Lifetime
- 1985-08-30 JP JP60189997A patent/JPS6160614A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0173242A3 (en) | 1987-10-07 |
| ES8702146A1 (es) | 1986-12-16 |
| JPS6160614A (ja) | 1986-03-28 |
| EP0173242B2 (de) | 1996-07-24 |
| JPH0580455B2 (enrdf_load_stackoverflow) | 1993-11-09 |
| CA1265051A (en) | 1990-01-30 |
| IL76260A (en) | 1992-02-16 |
| ATE73666T1 (de) | 1992-04-15 |
| EP0173242A2 (de) | 1986-03-05 |
| DK398185A (da) | 1986-03-01 |
| EP0173242B1 (de) | 1992-03-18 |
| DE3585649D1 (de) | 1992-04-23 |
| ES546526A0 (es) | 1986-12-16 |
| IL76260A0 (en) | 1986-01-31 |
| DK398185D0 (da) | 1985-08-30 |
| DE3432083A1 (de) | 1986-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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