DK173943B1 - Eventuelt substituerede indan- og hexahydroindan-2.2-diphosphonsyrer og farmaceutisk acceptable salte deraf samt farmaceutisk komposition omfattende samme - Google Patents
Eventuelt substituerede indan- og hexahydroindan-2.2-diphosphonsyrer og farmaceutisk acceptable salte deraf samt farmaceutisk komposition omfattende samme Download PDFInfo
- Publication number
- DK173943B1 DK173943B1 DK198505995A DK599585A DK173943B1 DK 173943 B1 DK173943 B1 DK 173943B1 DK 198505995 A DK198505995 A DK 198505995A DK 599585 A DK599585 A DK 599585A DK 173943 B1 DK173943 B1 DK 173943B1
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- calcium
- diphosphonic acid
- pharmaceutically acceptable
- acceptable salts
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
- 150000003839 salts Chemical class 0.000 title claims description 15
- XOHHVAJIJMPTME-UHFFFAOYSA-N (2-phosphono-1,3,3a,4,5,6,7,7a-octahydroinden-2-yl)phosphonic acid Chemical class C1CCCC2CC(P(O)(=O)O)(P(O)(O)=O)CC21 XOHHVAJIJMPTME-UHFFFAOYSA-N 0.000 title claims description 8
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N benzocyclopentane Natural products C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 title claims description 4
- 125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title 1
- -1 cyclic diphosphonic acid compounds Chemical class 0.000 claims abstract description 20
- 239000003937 drug carrier Substances 0.000 claims description 10
- WXDXVSRYEHLMPH-UHFFFAOYSA-N (2-phosphono-1,3-dihydroinden-2-yl)phosphonic acid Chemical compound C1=CC=C2CC(P(O)(=O)O)(P(O)(O)=O)CC2=C1 WXDXVSRYEHLMPH-UHFFFAOYSA-N 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 150000002468 indanes Chemical class 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 46
- 239000011575 calcium Substances 0.000 abstract description 38
- 229910052791 calcium Inorganic materials 0.000 abstract description 37
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 36
- 230000002159 abnormal effect Effects 0.000 abstract description 19
- 229910019142 PO4 Inorganic materials 0.000 abstract description 18
- 239000010452 phosphate Substances 0.000 abstract description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 18
- 230000004060 metabolic process Effects 0.000 abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 10
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- 239000000126 substance Substances 0.000 description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 11
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- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical class [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 10
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- 210000002966 serum Anatomy 0.000 description 10
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- 229910000389 calcium phosphate Inorganic materials 0.000 description 9
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- 230000008021 deposition Effects 0.000 description 8
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- 230000002401 inhibitory effect Effects 0.000 description 7
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- ODTQUKVFOLFLIQ-UHFFFAOYSA-N 2-[di(propan-2-yloxy)phosphorylmethyl-propan-2-yloxyphosphoryl]oxypropane Chemical compound CC(C)OP(=O)(OC(C)C)CP(=O)(OC(C)C)OC(C)C ODTQUKVFOLFLIQ-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
- C07F9/3852—Cycloaliphatic derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199300327A DK174685B1 (da) | 1984-12-21 | 1993-03-22 | Monocykliske geminale diphosphonsyrer og farmaceutisk acceptable salte heraf samt farmaceutisk sammensætning omfattende disse |
| DK199300328A DK173973B1 (da) | 1984-12-21 | 1993-03-22 | Geminale heterocycliske diphosphonsyrer og farmaceutisk acceptable salte heraf samt farmaceutiske sammensætning omfattende samme |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68454484 | 1984-12-21 | ||
| US06/684,544 US4687768A (en) | 1984-12-21 | 1984-12-21 | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK599585D0 DK599585D0 (da) | 1985-12-20 |
| DK599585A DK599585A (da) | 1986-06-22 |
| DK173943B1 true DK173943B1 (da) | 2002-03-04 |
Family
ID=24748496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198505995A DK173943B1 (da) | 1984-12-21 | 1985-12-20 | Eventuelt substituerede indan- og hexahydroindan-2.2-diphosphonsyrer og farmaceutisk acceptable salte deraf samt farmaceutisk komposition omfattende samme |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US4687768A (xx) |
| EP (3) | EP0304961B1 (xx) |
| JP (3) | JPH0699456B2 (xx) |
| AT (3) | ATE92932T1 (xx) |
| AU (1) | AU583873B2 (xx) |
| CA (1) | CA1279872C (xx) |
| DE (3) | DE3586543T2 (xx) |
| DK (1) | DK173943B1 (xx) |
| ES (1) | ES8704958A1 (xx) |
| IE (1) | IE58272B1 (xx) |
| IL (1) | IL77242A (xx) |
| NZ (1) | NZ214650A (xx) |
| PH (2) | PH23500A (xx) |
| ZA (1) | ZA859361B (xx) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| GB8618259D0 (en) * | 1986-07-25 | 1986-09-03 | Leo Pharm Prod Ltd | Pharmaceutical compositions |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| US4877603A (en) * | 1987-12-18 | 1989-10-31 | The Procter & Gamble Company | Oral compositions |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US5220021A (en) * | 1989-04-03 | 1993-06-15 | The Upjohn Company | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
| EP0466730B1 (en) * | 1989-04-03 | 1993-07-21 | The Upjohn Company | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| US5139786A (en) * | 1989-07-07 | 1992-08-18 | Ciba-Geigy Corporation | Topical formulations |
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| AU624733B2 (en) * | 1989-09-14 | 1992-06-18 | Symphar S.A. | Naphthalene and tetrahydronaphthalene substituted gem- diphosphonate compounds and their use in therapy |
| CZ297094A3 (en) * | 1992-05-29 | 1995-12-13 | Procter & Gamble Pharma | Phosphate compounds containing quaternary nitrogen, their use and pharmaceutical compositions containing thereof |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| US3988433A (en) * | 1973-08-10 | 1976-10-26 | The Procter & Gamble Company | Oral compositions for preventing or removing stains from teeth |
| US3988443A (en) * | 1973-08-27 | 1976-10-26 | Henkel & Cie G.M.B.H. | Azacycloalkane-2,2-diphosphonic acids |
| DE2343147C2 (de) * | 1973-08-27 | 1982-06-09 | Henkel KGaA, 4000 Düsseldorf | Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung |
| US4034086A (en) * | 1973-08-27 | 1977-07-05 | Henkel & Cie G.M.B.H. | Pyrrolidone-5,5-diphosphonic acids |
| DE2343196C3 (de) * | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
| DE2543349C2 (de) * | 1975-09-29 | 1984-05-10 | Henkel KGaA, 4000 Düsseldorf | Preaparate zur herstellung von99m technetium-radiagnostica |
| SE7612534L (sv) * | 1975-12-01 | 1977-06-02 | Henkel & Cie Gmbh | Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning |
| US4330537A (en) * | 1977-12-07 | 1982-05-18 | The Procter & Gamble Company | Compositions for inhibiting mobilization of calcium phosphate in animal tissue |
-
1984
- 1984-12-21 US US06/684,544 patent/US4687768A/en not_active Expired - Lifetime
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1985
- 1985-12-05 IL IL77242A patent/IL77242A/xx not_active IP Right Cessation
- 1985-12-06 ZA ZA859361A patent/ZA859361B/xx unknown
- 1985-12-16 EP EP88114436A patent/EP0304961B1/en not_active Expired - Lifetime
- 1985-12-16 AT AT88114436T patent/ATE92932T1/de not_active IP Right Cessation
- 1985-12-16 EP EP85309142A patent/EP0189662B1/en not_active Expired
- 1985-12-16 DE DE8888114437T patent/DE3586543T2/de not_active Expired - Fee Related
- 1985-12-16 DE DE8585309142T patent/DE3572822D1/de not_active Expired
- 1985-12-16 AT AT88114437T patent/ATE79628T1/de not_active IP Right Cessation
- 1985-12-16 DE DE88114436T patent/DE3587527T2/de not_active Expired - Fee Related
- 1985-12-16 EP EP88114437A patent/EP0304962B1/en not_active Expired - Lifetime
- 1985-12-16 AT AT85309142T patent/ATE46167T1/de not_active IP Right Cessation
- 1985-12-17 PH PH33193A patent/PH23500A/en unknown
- 1985-12-19 CA CA000498175A patent/CA1279872C/en not_active Expired - Fee Related
- 1985-12-20 NZ NZ214650A patent/NZ214650A/xx unknown
- 1985-12-20 ES ES550243A patent/ES8704958A1/es not_active Expired
- 1985-12-20 IE IE328585A patent/IE58272B1/en not_active IP Right Cessation
- 1985-12-20 AU AU51538/85A patent/AU583873B2/en not_active Ceased
- 1985-12-20 DK DK198505995A patent/DK173943B1/da not_active IP Right Cessation
- 1985-12-21 JP JP60289125A patent/JPH0699456B2/ja not_active Expired - Fee Related
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1987
- 1987-08-14 US US07/085,906 patent/US4939131A/en not_active Expired - Lifetime
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1988
- 1988-11-09 PH PH37782A patent/PH25769A/en unknown
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1994
- 1994-05-30 JP JP6117250A patent/JPH07113037B2/ja not_active Expired - Fee Related
- 1994-05-30 JP JP6117242A patent/JP2680264B2/ja not_active Expired - Fee Related
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