DK173282A - Glycopeptid-ligand, fremgangsmaade til fremstilling deraf, mellemprodukt til brug ved fremgangsmaaden og anvendelse af glycopeptid-liganden - Google Patents

Glycopeptid-ligand, fremgangsmaade til fremstilling deraf, mellemprodukt til brug ved fremgangsmaaden og anvendelse af glycopeptid-liganden Download PDF

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Publication number
DK173282A
DK173282A DK173282A DK173282A DK173282A DK 173282 A DK173282 A DK 173282A DK 173282 A DK173282 A DK 173282A DK 173282 A DK173282 A DK 173282A DK 173282 A DK173282 A DK 173282A
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DK
Denmark
Prior art keywords
ligand
glycopeptid
mannopyranosylthio
metabolizable
propionyl
Prior art date
Application number
DK173282A
Other languages
Danish (da)
English (en)
Inventor
Robert L Bugianesi
Mitree M Ponpipom
James C Robbins
Tsung-Ying Shen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK173282A publication Critical patent/DK173282A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK173282A 1981-04-20 1982-04-19 Glycopeptid-ligand, fremgangsmaade til fremstilling deraf, mellemprodukt til brug ved fremgangsmaaden og anvendelse af glycopeptid-liganden DK173282A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/255,416 US4386026A (en) 1981-04-20 1981-04-20 Cell-specific glycopeptide ligands

Publications (1)

Publication Number Publication Date
DK173282A true DK173282A (da) 1982-10-21

Family

ID=22968229

Family Applications (1)

Application Number Title Priority Date Filing Date
DK173282A DK173282A (da) 1981-04-20 1982-04-19 Glycopeptid-ligand, fremgangsmaade til fremstilling deraf, mellemprodukt til brug ved fremgangsmaaden og anvendelse af glycopeptid-liganden

Country Status (10)

Country Link
US (1) US4386026A (fr)
EP (1) EP0063373B1 (fr)
JP (1) JPS57181095A (fr)
AT (1) ATE18562T1 (fr)
DE (1) DE3269778D1 (fr)
DK (1) DK173282A (fr)
ES (1) ES8306162A1 (fr)
GR (1) GR76475B (fr)
IE (1) IE52473B1 (fr)
PT (1) PT74747B (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701521A (en) * 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4466951A (en) * 1982-11-12 1984-08-21 University Of California Intracellular trapping of therapeutics or tracer agents
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US4946675A (en) * 1987-05-27 1990-08-07 Xoma Corporation Hepatic blocking agents
US5879680A (en) * 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
JPH05503691A (ja) * 1989-12-29 1993-06-17 ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの３次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト
US5432260A (en) * 1991-05-03 1995-07-11 Washington University High affinity mannose receptor ligands
US5332575A (en) * 1991-10-03 1994-07-26 Parfums Christian Dior Method of targeting melanocytes with a compound containing a fucose residue
WO1993025197A1 (fr) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions et procedes destines a ameliorer la liberation et l'acheminement de medicaments
TW263437B (fr) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
WO1995010296A1 (fr) * 1993-10-12 1995-04-20 Glycomed Incorporated Banque de glyco-peptides permettant d'identifier des inhibiteurs d'adherence intercellulaire
JP4256932B2 (ja) * 1995-06-07 2009-04-22 ジョエル ケイ． スワデッシュ 抗原プロセシング細胞標的複合体
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
WO1998031392A1 (fr) * 1997-01-17 1998-07-23 Drug Delivery System Institute, Ltd. Medicaments nephrotropiques
US7033765B1 (en) 1997-02-20 2006-04-25 Toronto Research Chemicals, Inc. Site-specific drug delivery
DE69830305T2 (de) * 1997-02-20 2006-02-02 Dime, David S., Toronto Ortsspezifische arzneimittel verabreichung
ES2265162T3 (es) * 1997-03-27 2007-02-01 Institut Pasteur Carbohidrato glucopeptido de antigeno multiple, vacuna que comprende el mismo y su utilizacion.
PT1001961E (pt) * 1997-08-08 2005-04-29 Aventis Pharma Gmbh Derivados substituidos de tetra-hidropirano bem como processo para a sua preparacao
IL142842A0 (en) * 1998-10-30 2002-03-10 Daiichi Seiyaku Co Dds compounds and method for assaying the same
WO2000030444A1 (fr) * 1998-11-25 2000-06-02 Vanderbilt University Liposomes cationiques pour transfert genique
AU2001260729A1 (en) * 2000-07-26 2002-02-13 Cho, Sung-Woo Oligolysine transducing domain, oligolysine-cargo molecule complex and uses thereof
CA2497195C (fr) 2001-12-14 2014-07-08 The University Of Wyoming Methodes et compositions de liberation controlee de medicaments
CN103804458B (zh) * 2014-02-25 2016-08-24 中国人民解放军第四军医大学 基于胆固醇的三种脂质材料的制备及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226379A (en) * 1964-01-14 1965-12-28 Grace W R & Co Novel 1,3-bis(polyhydroxyalkyl)-2-imidazolidinones and 1,3-bis(polyhydroxyalkyl)-imidazolidine-2-thiones
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
US3953594A (en) * 1971-08-13 1976-04-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing bleomycin group antibiotics
IT1050366B (it) * 1972-10-18 1981-03-10 Chinos Ind Farmacobilologica S Sali di amminoacidi con esteri polisolforici di glicopeptidi naturali e loro preparazione
US4195128A (en) * 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
SE431758B (sv) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer
US4120953A (en) * 1977-04-04 1978-10-17 American Cyanamid Company Novel 2,2', 2"-[s-phenenyltris(sulfonylimino)tris]-[2-deoxy-α-D-glucopyranose], dodecakis (H-sulfate) compounds and their salts
US4241053A (en) * 1978-08-25 1980-12-23 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
GB2044262B (en) * 1979-03-05 1983-01-26 Nippon Kayaku Kk Bleomycin group antibiotics
JPS5646897A (en) * 1979-09-26 1981-04-28 Seiichi Shibata Novel glycopeptide
US4259233A (en) * 1979-10-23 1981-03-31 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
CA1203532A (fr) * 1980-07-10 1986-04-22 Chembiomed Ltd. Synthese de determinants antigeniques pours les tumeurs

Also Published As

Publication number Publication date
GR76475B (fr) 1984-08-10
PT74747B (en) 1985-01-08
JPS57181095A (en) 1982-11-08
ES511516A0 (es) 1983-05-01
EP0063373A1 (fr) 1982-10-27
ATE18562T1 (de) 1986-03-15
ES8306162A1 (es) 1983-05-01
US4386026A (en) 1983-05-31
DE3269778D1 (en) 1986-04-17
IE820898L (en) 1982-10-20
PT74747A (en) 1982-05-01
EP0063373B1 (fr) 1986-03-12
IE52473B1 (en) 1987-11-11

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Legal Events

Date Code Title Description
ATS Application withdrawn
B1 Patent granted (law 1993)