GR76475B - - Google Patents
Info
- Publication number
- GR76475B GR76475B GR67908A GR820167908A GR76475B GR 76475 B GR76475 B GR 76475B GR 67908 A GR67908 A GR 67908A GR 820167908 A GR820167908 A GR 820167908A GR 76475 B GR76475 B GR 76475B
- Authority
- GR
- Greece
- Prior art keywords
- mannopyranosylthio
- metabolizable
- propionyl
- lysine
- peptides
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000015872 Gaucher disease Diseases 0.000 abstract 1
- 102000004547 Glucosylceramidase Human genes 0.000 abstract 1
- 108010017544 Glucosylceramidase Proteins 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- -1 dilysine Chemical compound 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002641 enzyme replacement therapy Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 210000001865 kupffer cell Anatomy 0.000 abstract 1
- 108010054155 lysyllysine Proteins 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/255,416 US4386026A (en) | 1981-04-20 | 1981-04-20 | Cell-specific glycopeptide ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR76475B true GR76475B (el) | 1984-08-10 |
Family
ID=22968229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR67908A GR76475B (el) | 1981-04-20 | 1982-04-13 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4386026A (el) |
| EP (1) | EP0063373B1 (el) |
| JP (1) | JPS57181095A (el) |
| AT (1) | ATE18562T1 (el) |
| DE (1) | DE3269778D1 (el) |
| DK (1) | DK173282A (el) |
| ES (1) | ES8306162A1 (el) |
| GR (1) | GR76475B (el) |
| IE (1) | IE52473B1 (el) |
| PT (1) | PT74747B (el) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701521A (en) * | 1978-07-17 | 1987-10-20 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US4466951A (en) * | 1982-11-12 | 1984-08-21 | University Of California | Intracellular trapping of therapeutics or tracer agents |
| FR2551442B1 (fr) * | 1983-09-05 | 1987-04-30 | Centre Nat Rech Scient | Nouveaux derives furaniques, leur preparation et leur application |
| US4873322A (en) * | 1986-01-24 | 1989-10-10 | Ciba-Geigy Corporation | Saccharide derivatives and processes for their manufacture |
| US4946675A (en) * | 1987-05-27 | 1990-08-07 | Xoma Corporation | Hepatic blocking agents |
| US5879680A (en) * | 1987-12-23 | 1999-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned DNA for synthesizing unique glucocerebrosidase |
| JPH05503691A (ja) * | 1989-12-29 | 1993-06-17 | ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド | アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの３次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト |
| US5432260A (en) * | 1991-05-03 | 1995-07-11 | Washington University | High affinity mannose receptor ligands |
| US5332575A (en) * | 1991-10-03 | 1994-07-26 | Parfums Christian Dior | Method of targeting melanocytes with a compound containing a fucose residue |
| WO1993025197A1 (en) * | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| TW263437B (el) * | 1992-09-24 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US5508387A (en) * | 1993-08-04 | 1996-04-16 | Glycomed Incorporated | Selectin binding glycopeptides |
| WO1995010296A1 (en) * | 1993-10-12 | 1995-04-20 | Glycomed Incorporated | A library of glyco-peptides useful for identification of cell adhesion inhibitors |
| DE69612093T2 (de) * | 1995-06-07 | 2001-10-31 | Martin Sevoian | Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend |
| US5965719A (en) * | 1996-11-15 | 1999-10-12 | Sunsorb Biotech, Inc. | Combinatorial synthesis of carbohydrate libraries |
| WO1998031392A1 (en) * | 1997-01-17 | 1998-07-23 | Drug Delivery System Institute, Ltd. | Nephrotropic drugs |
| EP0966304B1 (en) * | 1997-02-20 | 2005-05-25 | David S. Dime | Site-specific drug delivery |
| US7033765B1 (en) | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
| CA2285018C (en) * | 1997-03-27 | 2011-01-04 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof |
| PT1001961E (pt) * | 1997-08-08 | 2005-04-29 | Aventis Pharma Gmbh | Derivados substituidos de tetra-hidropirano bem como processo para a sua preparacao |
| CN1661044A (zh) * | 1998-10-30 | 2005-08-31 | 第一制药株式会社 | Dds化合物及其测定方法 |
| WO2000030444A1 (en) * | 1998-11-25 | 2000-06-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| AU2001260729A1 (en) * | 2000-07-26 | 2002-02-13 | Cho, Sung-Woo | Oligolysine transducing domain, oligolysine-cargo molecule complex and uses thereof |
| WO2003051113A1 (en) | 2001-12-14 | 2003-06-26 | The University Of Wyoming | Methods and compositions for controlled release of drugs |
| CN103804458B (zh) * | 2014-02-25 | 2016-08-24 | 中国人民解放军第四军医大学 | 基于胆固醇的三种脂质材料的制备及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226379A (en) * | 1964-01-14 | 1965-12-28 | Grace W R & Co | Novel 1,3-bis(polyhydroxyalkyl)-2-imidazolidinones and 1,3-bis(polyhydroxyalkyl)-imidazolidine-2-thiones |
| US3859337A (en) * | 1969-06-11 | 1975-01-07 | Stauffer Chemical Co | Ethylenediaminetetraacetic acid anhydride derivatives |
| US3953594A (en) * | 1971-08-13 | 1976-04-27 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for preparing bleomycin group antibiotics |
| IT1050366B (it) * | 1972-10-18 | 1981-03-10 | Chinos Ind Farmacobilologica S | Sali di amminoacidi con esteri polisolforici di glicopeptidi naturali e loro preparazione |
| US4195128A (en) * | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| SE431758B (sv) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer |
| US4120953A (en) * | 1977-04-04 | 1978-10-17 | American Cyanamid Company | Novel 2,2', 2"-[s-phenenyltris(sulfonylimino)tris]-[2-deoxy-α-D-glucopyranose], dodecakis (H-sulfate) compounds and their salts |
| NL7906191A (nl) * | 1978-08-25 | 1980-02-27 | Tanabe Seiyaku Co | Nieuwe nitrosoureumderivaten en de bereidingswijze daarvan. |
| US4223013A (en) * | 1978-12-29 | 1980-09-16 | Syva Company | Amitriptyline conjugates to antigenic proteins and enzymes |
| US4267102A (en) * | 1979-03-05 | 1981-05-12 | Nippon Kayaku Kabushiki Kaisha | Bleomycin group antibiotics |
| JPS5646897A (en) * | 1979-09-26 | 1981-04-28 | Seiichi Shibata | Novel glycopeptide |
| US4259233A (en) * | 1979-10-23 | 1981-03-31 | Miles Laboratories, Inc. | β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
| CA1203532A (en) * | 1980-07-10 | 1986-04-22 | Chembiomed Ltd. | Synthesis of tumor antigenic determinant |
-
1981
- 1981-04-20 US US06/255,416 patent/US4386026A/en not_active Expired - Fee Related
-
1982
- 1982-04-13 GR GR67908A patent/GR76475B/el unknown
- 1982-04-14 PT PT74747A patent/PT74747B/pt not_active IP Right Cessation
- 1982-04-16 IE IE898/82A patent/IE52473B1/en not_active IP Right Cessation
- 1982-04-19 DE DE8282103247T patent/DE3269778D1/de not_active Expired
- 1982-04-19 EP EP82103247A patent/EP0063373B1/en not_active Expired
- 1982-04-19 DK DK173282A patent/DK173282A/da active IP Right Grant
- 1982-04-19 ES ES511516A patent/ES8306162A1/es not_active Expired
- 1982-04-19 AT AT82103247T patent/ATE18562T1/de not_active IP Right Cessation
- 1982-04-20 JP JP57064870A patent/JPS57181095A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES511516A0 (es) | 1983-05-01 |
| PT74747B (en) | 1985-01-08 |
| US4386026A (en) | 1983-05-31 |
| DK173282A (da) | 1982-10-21 |
| ATE18562T1 (de) | 1986-03-15 |
| IE820898L (en) | 1982-10-20 |
| EP0063373A1 (en) | 1982-10-27 |
| PT74747A (en) | 1982-05-01 |
| IE52473B1 (en) | 1987-11-11 |
| ES8306162A1 (es) | 1983-05-01 |
| EP0063373B1 (en) | 1986-03-12 |
| DE3269778D1 (en) | 1986-04-17 |
| JPS57181095A (en) | 1982-11-08 |
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