ATE18562T1 - Zellspezifische glykopeptidliganden. - Google Patents

Zellspezifische glykopeptidliganden.

Info

Publication number
ATE18562T1
ATE18562T1 AT82103247T AT82103247T ATE18562T1 AT E18562 T1 ATE18562 T1 AT E18562T1 AT 82103247 T AT82103247 T AT 82103247T AT 82103247 T AT82103247 T AT 82103247T AT E18562 T1 ATE18562 T1 AT E18562T1
Authority
AT
Austria
Prior art keywords
cell
mannopyranosylthio
metabolizable
propionyl
lysine
Prior art date
Application number
AT82103247T
Other languages
English (en)
Inventor
Mitree M Ponpipom
Robert L Bugianesi
James C Robbins
Tsung-Ying Shen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE18562T1 publication Critical patent/ATE18562T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT82103247T 1981-04-20 1982-04-19 Zellspezifische glykopeptidliganden. ATE18562T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/255,416 US4386026A (en) 1981-04-20 1981-04-20 Cell-specific glycopeptide ligands
EP82103247A EP0063373B1 (de) 1981-04-20 1982-04-19 Zellspezifische Glykopeptidliganden

Publications (1)

Publication Number Publication Date
ATE18562T1 true ATE18562T1 (de) 1986-03-15

Family

ID=22968229

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82103247T ATE18562T1 (de) 1981-04-20 1982-04-19 Zellspezifische glykopeptidliganden.

Country Status (10)

Country Link
US (1) US4386026A (de)
EP (1) EP0063373B1 (de)
JP (1) JPS57181095A (de)
AT (1) ATE18562T1 (de)
DE (1) DE3269778D1 (de)
DK (1) DK173282A (de)
ES (1) ES8306162A1 (de)
GR (1) GR76475B (de)
IE (1) IE52473B1 (de)
PT (1) PT74747B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701521A (en) * 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4466951A (en) * 1982-11-12 1984-08-21 University Of California Intracellular trapping of therapeutics or tracer agents
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US4946675A (en) * 1987-05-27 1990-08-07 Xoma Corporation Hepatic blocking agents
US5879680A (en) * 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US5432260A (en) * 1991-05-03 1995-07-11 Washington University High affinity mannose receptor ligands
US5332575A (en) * 1991-10-03 1994-07-26 Parfums Christian Dior Method of targeting melanocytes with a compound containing a fucose residue
EP0647133A4 (de) * 1992-06-12 1997-10-29 Affymax Tech Nv Zusammensetzungen und verfahren zur verbesserte arzneimittelabgabe.
TW263437B (de) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
JP4256932B2 (ja) * 1995-06-07 2009-04-22 ジョエル ケイ． スワデッシュ 抗原プロセシング細胞標的複合体
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
WO1998031392A1 (fr) * 1997-01-17 1998-07-23 Drug Delivery System Institute, Ltd. Medicaments nephrotropiques
NZ337924A (en) * 1997-02-20 2002-09-27 Klaus Kimmeldirk Site-specific drug delivery compounds comprising an anchoring moiety, a linking group and a drug
US7033765B1 (en) 1997-02-20 2006-04-25 Toronto Research Chemicals, Inc. Site-specific drug delivery
ES2265162T3 (es) * 1997-03-27 2007-02-01 Institut Pasteur Carbohidrato glucopeptido de antigeno multiple, vacuna que comprende el mismo y su utilizacion.
CA2299295C (en) * 1997-08-08 2010-11-30 Aventis Pharma Deutschland Gmbh Substituted tetrahydropyrane derivatives and method for producing same
CA2348931A1 (en) * 1998-10-30 2000-05-11 Daiichi Pharmaceutical Co., Ltd. Dds compound and method for measurement thereof
US6656498B1 (en) * 1998-11-25 2003-12-02 Vanderbilt University Cationic liposomes for gene transfer
WO2002010219A1 (en) * 2000-07-26 2002-02-07 Cho, Sung-Woo Oligolysine transducing domain, oligolysine-cargo molecule complex and uses thereof
WO2003051113A1 (en) 2001-12-14 2003-06-26 The University Of Wyoming Methods and compositions for controlled release of drugs
CN103804458B (zh) * 2014-02-25 2016-08-24 中国人民解放军第四军医大学 基于胆固醇的三种脂质材料的制备及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226379A (en) * 1964-01-14 1965-12-28 Grace W R & Co Novel 1,3-bis(polyhydroxyalkyl)-2-imidazolidinones and 1,3-bis(polyhydroxyalkyl)-imidazolidine-2-thiones
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
US3953594A (en) * 1971-08-13 1976-04-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing bleomycin group antibiotics
IT1050366B (it) * 1972-10-18 1981-03-10 Chinos Ind Farmacobilologica S Sali di amminoacidi con esteri polisolforici di glicopeptidi naturali e loro preparazione
US4195128A (en) * 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
SE431758B (sv) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer
US4120953A (en) * 1977-04-04 1978-10-17 American Cyanamid Company Novel 2,2', 2"-[s-phenenyltris(sulfonylimino)tris]-[2-deoxy-α-D-glucopyranose], dodecakis (H-sulfate) compounds and their salts
US4241053A (en) * 1978-08-25 1980-12-23 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4267102A (en) * 1979-03-05 1981-05-12 Nippon Kayaku Kabushiki Kaisha Bleomycin group antibiotics
JPS5646897A (en) * 1979-09-26 1981-04-28 Seiichi Shibata Novel glycopeptide
US4259233A (en) * 1979-10-23 1981-03-31 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
CA1203532A (en) * 1980-07-10 1986-04-22 Chembiomed Ltd. Synthesis of tumor antigenic determinant

Also Published As

Publication number Publication date
PT74747B (en) 1985-01-08
ES511516A0 (es) 1983-05-01
PT74747A (en) 1982-05-01
GR76475B (de) 1984-08-10
IE52473B1 (en) 1987-11-11
DE3269778D1 (en) 1986-04-17
JPS57181095A (en) 1982-11-08
ES8306162A1 (es) 1983-05-01
US4386026A (en) 1983-05-31
IE820898L (en) 1982-10-20
EP0063373A1 (de) 1982-10-27
EP0063373B1 (de) 1986-03-12
DK173282A (da) 1982-10-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee