DK172798B1 - Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin - Google Patents

Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin Download PDF

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Publication number
DK172798B1
DK172798B1 DK198303255A DK325583A DK172798B1 DK 172798 B1 DK172798 B1 DK 172798B1 DK 198303255 A DK198303255 A DK 198303255A DK 325583 A DK325583 A DK 325583A DK 172798 B1 DK172798 B1 DK 172798B1
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DK
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Prior art keywords
heparin
molecular weight
low molecular
approx
depolymerization
Prior art date
Application number
DK198303255A
Other languages
Danish (da)
English (en)
Other versions
DK325583A (da
DK325583D0 (da
Inventor
Milton R Smith
Eduardo Amaya
Fernando Fussi
Original Assignee
Pharmacia & Upjohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn filed Critical Pharmacia & Upjohn
Publication of DK325583D0 publication Critical patent/DK325583D0/da
Publication of DK325583A publication Critical patent/DK325583A/da
Application granted granted Critical
Publication of DK172798B1 publication Critical patent/DK172798B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198303255A 1982-07-19 1983-07-14 Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin DK172798B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39921782A 1982-07-19 1982-07-19
US39921782 1982-07-19

Publications (3)

Publication Number Publication Date
DK325583D0 DK325583D0 (da) 1983-07-14
DK325583A DK325583A (da) 1984-01-20
DK172798B1 true DK172798B1 (da) 1999-07-19

Family

ID=23578637

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198303255A DK172798B1 (da) 1982-07-19 1983-07-14 Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin

Country Status (10)

Country Link
EP (1) EP0101141A3 (fr)
JP (1) JPS5920302A (fr)
AR (1) AR231644A1 (fr)
AU (1) AU1033183A (fr)
CA (1) CA1195322A (fr)
DK (1) DK172798B1 (fr)
ES (1) ES8402319A1 (fr)
NZ (1) NZ202996A (fr)
PT (1) PT76111A (fr)
ZA (1) ZA829463B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
ATE122059T1 (de) * 1986-08-20 1995-05-15 Univ Miami Alkylesters of heparin mit niedrigem molecular gewicht.
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (fr) * 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central
HUP0201712A3 (en) * 1999-06-30 2003-03-28 Weitz Jeffrey I Ancaster Clot associated coagulation factors inhibiting heparin compositions
JP2002293804A (ja) * 2001-03-28 2002-10-09 Itoham Foods Inc 低分子量ヘパリンの製造法
WO2022015794A1 (fr) 2020-07-14 2022-01-20 Optimvia, Llc Procédés de synthèse de sulfate d'héparane non anticoagulant
CA3144968A1 (fr) 2019-07-09 2021-01-14 Optimvia Llc Procedes de synthese de polysaccharides anticoagulants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179566A (en) * 1963-05-16 1965-04-20 Canada Packers Ltd Purification of heparin
US3482014A (en) * 1966-06-29 1969-12-02 Canada Packers Ltd Orally active heparin and method for making and using same
CA1136620A (fr) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Fragments d'heparine ayant une activite anticoagulante selective
JPS56120704A (en) * 1980-01-28 1981-09-22 Hepar Ind Inc Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Also Published As

Publication number Publication date
JPH0442401B2 (fr) 1992-07-13
AU1033183A (en) 1984-01-26
PT76111A (en) 1983-02-01
DK325583A (da) 1984-01-20
AR231644A1 (es) 1985-01-31
EP0101141A3 (fr) 1985-05-22
ES519015A0 (es) 1984-02-01
CA1195322A (fr) 1985-10-15
EP0101141A2 (fr) 1984-02-22
ES8402319A1 (es) 1984-02-01
NZ202996A (en) 1985-10-11
JPS5920302A (ja) 1984-02-02
DK325583D0 (da) 1983-07-14
ZA829463B (en) 1983-10-26

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