DK172788B1 - Anvendelse af castanosperminestere til fremstilling af et farmaceutisk præparat - Google Patents

Anvendelse af castanosperminestere til fremstilling af et farmaceutisk præparat Download PDF

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Publication number
DK172788B1
DK172788B1 DK198805388A DK538888A DK172788B1 DK 172788 B1 DK172788 B1 DK 172788B1 DK 198805388 A DK198805388 A DK 198805388A DK 538888 A DK538888 A DK 538888A DK 172788 B1 DK172788 B1 DK 172788B1
Authority
DK
Denmark
Prior art keywords
acid
castanospermine
preparation
pharmaceutical composition
octahydro
Prior art date
Application number
DK198805388A
Other languages
Danish (da)
English (en)
Other versions
DK538888A (da
DK538888D0 (da
Inventor
Paul S Liu
Terry L Bowlin
Sai P Sunkara
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK538888D0 publication Critical patent/DK538888D0/da
Publication of DK538888A publication Critical patent/DK538888A/da
Application granted granted Critical
Publication of DK172788B1 publication Critical patent/DK172788B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK198805388A 1987-09-29 1988-09-28 Anvendelse af castanosperminestere til fremstilling af et farmaceutisk præparat DK172788B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10207087 1987-09-29
US07/102,070 US5004746A (en) 1987-09-29 1987-09-29 Anti-retroviral castanospermine esters

Publications (3)

Publication Number Publication Date
DK538888D0 DK538888D0 (da) 1988-09-28
DK538888A DK538888A (da) 1989-03-30
DK172788B1 true DK172788B1 (da) 1999-07-19

Family

ID=22287973

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198805388A DK172788B1 (da) 1987-09-29 1988-09-28 Anvendelse af castanosperminestere til fremstilling af et farmaceutisk præparat

Country Status (12)

Country Link
US (1) US5004746A (ko)
EP (1) EP0309952B1 (ko)
JP (1) JP2761898B2 (ko)
KR (1) KR960009416B1 (ko)
AT (1) ATE107506T1 (ko)
AU (1) AU614993B2 (ko)
DE (1) DE3850335T2 (ko)
DK (1) DK172788B1 (ko)
ES (1) ES2058201T3 (ko)
IE (1) IE64311B1 (ko)
PH (1) PH24431A (ko)
ZA (1) ZA887160B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis
ZA908134B (en) * 1989-10-17 1991-07-31 Merrell Dow Pharma Esters of castanosperime in the treatment of cerebral malaria
US5214050A (en) * 1989-10-17 1993-05-25 Merrell Dow Pharmaceuticals Inc. Esters of castanospermine in the treatment of cerebral malaria
GB8924292D0 (en) * 1989-10-27 1989-12-13 Novalal Ltd The production of a novel dimer chemical product"novo dimers"by the polymersation of indolizidine alkaloids using cyclo dextrin glucosyl transferase
US5028614A (en) * 1990-03-30 1991-07-02 Merrell Dow Pharmaceuticals Inc. Hydroxymethyl-indolizidines and quinolizidines and their use as α-glucosidase I inhibitors
GB9027433D0 (en) * 1990-12-18 1991-02-06 Merrell Dow Pharma Anti-herpes castanospermine esters
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
GB9303518D0 (en) * 1993-02-22 1993-04-07 Merrell Dow Pharma Combinations of retroviral inhibitors
US5959111A (en) * 1997-05-22 1999-09-28 Hoechst Marion Roussel, Inc. Process for preparing 6-0-monoesters of castanospermine
AU739675B2 (en) * 1997-05-22 2001-10-18 Aventisub Ii Inc. Process for preparing 6-O-monoesters of castanospermine
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
US20060052414A1 (en) * 2004-08-13 2006-03-09 Migenix, Inc. Compositions and methods for treating or preventing Hepadnaviridae infection
CA2583351A1 (en) * 2004-10-06 2006-04-13 Migenix Inc. Combination anti-viral compositions comprising castanospermine and methods of use
WO2008088581A2 (en) * 2006-08-02 2008-07-24 United Therapeutics Corporation Liposome treatment of viral infections
WO2009118658A2 (en) * 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
JP2012521981A (ja) * 2009-03-27 2012-09-20 ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード コレステロールレベル低下リポソーム
EP4106752A4 (en) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
ZA883925B (en) * 1987-06-08 1989-02-22 Merrell Dow Pharma Inhibitors of glycoprotein processing having anti-retroviral activity
CA1315276C (en) * 1987-07-02 1993-03-30 Paul S. Liu Castanospermine esters and glycosides
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis

Also Published As

Publication number Publication date
IE882933L (en) 1989-03-29
JPH01106821A (ja) 1989-04-24
DK538888A (da) 1989-03-30
EP0309952A3 (en) 1990-09-26
DE3850335T2 (de) 1994-10-13
JP2761898B2 (ja) 1998-06-04
IE64311B1 (en) 1995-07-26
ATE107506T1 (de) 1994-07-15
EP0309952B1 (en) 1994-06-22
KR960009416B1 (en) 1996-07-19
DK538888D0 (da) 1988-09-28
ZA887160B (en) 1989-05-30
KR890004701A (ko) 1989-05-09
AU2280288A (en) 1989-04-06
DE3850335D1 (de) 1994-07-28
US5004746A (en) 1991-04-02
PH24431A (en) 1990-06-25
ES2058201T3 (es) 1994-11-01
EP0309952A2 (en) 1989-04-05
AU614993B2 (en) 1991-09-19

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