KR960009416B1 - Anti-retroviral castanospermine esters - Google Patents

Anti-retroviral castanospermine esters Download PDF

Info

Publication number
KR960009416B1
KR960009416B1 KR88012544A KR880012544A KR960009416B1 KR 960009416 B1 KR960009416 B1 KR 960009416B1 KR 88012544 A KR88012544 A KR 88012544A KR 880012544 A KR880012544 A KR 880012544A KR 960009416 B1 KR960009416 B1 KR 960009416B1
Authority
KR
South Korea
Prior art keywords
retroviral
castanospermine esters
castanospermine
esters
aids
Prior art date
Application number
KR88012544A
Other languages
English (en)
Other versions
KR890004701A (ko
Inventor
Paul S Liu
Sai P Sunkara
Terry L Bowlin
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of KR890004701A publication Critical patent/KR890004701A/ko
Application granted granted Critical
Publication of KR960009416B1 publication Critical patent/KR960009416B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR88012544A 1987-09-29 1988-09-28 Anti-retroviral castanospermine esters KR960009416B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/102,070 US5004746A (en) 1987-09-29 1987-09-29 Anti-retroviral castanospermine esters
US102,070 1987-09-29

Publications (2)

Publication Number Publication Date
KR890004701A KR890004701A (ko) 1989-05-09
KR960009416B1 true KR960009416B1 (en) 1996-07-19

Family

ID=22287973

Family Applications (1)

Application Number Title Priority Date Filing Date
KR88012544A KR960009416B1 (en) 1987-09-29 1988-09-28 Anti-retroviral castanospermine esters

Country Status (12)

Country Link
US (1) US5004746A (ko)
EP (1) EP0309952B1 (ko)
JP (1) JP2761898B2 (ko)
KR (1) KR960009416B1 (ko)
AT (1) ATE107506T1 (ko)
AU (1) AU614993B2 (ko)
DE (1) DE3850335T2 (ko)
DK (1) DK172788B1 (ko)
ES (1) ES2058201T3 (ko)
IE (1) IE64311B1 (ko)
PH (1) PH24431A (ko)
ZA (1) ZA887160B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis
ZA908134B (en) * 1989-10-17 1991-07-31 Merrell Dow Pharma Esters of castanosperime in the treatment of cerebral malaria
US5214050A (en) * 1989-10-17 1993-05-25 Merrell Dow Pharmaceuticals Inc. Esters of castanospermine in the treatment of cerebral malaria
GB8924292D0 (en) * 1989-10-27 1989-12-13 Novalal Ltd The production of a novel dimer chemical product"novo dimers"by the polymersation of indolizidine alkaloids using cyclo dextrin glucosyl transferase
US5028614A (en) * 1990-03-30 1991-07-02 Merrell Dow Pharmaceuticals Inc. Hydroxymethyl-indolizidines and quinolizidines and their use as α-glucosidase I inhibitors
GB9027433D0 (en) * 1990-12-18 1991-02-06 Merrell Dow Pharma Anti-herpes castanospermine esters
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
GB9303518D0 (en) * 1993-02-22 1993-04-07 Merrell Dow Pharma Combinations of retroviral inhibitors
US5959111A (en) * 1997-05-22 1999-09-28 Hoechst Marion Roussel, Inc. Process for preparing 6-0-monoesters of castanospermine
AU739675B2 (en) * 1997-05-22 2001-10-18 Aventisub Ii Inc. Process for preparing 6-O-monoesters of castanospermine
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
US20060052414A1 (en) * 2004-08-13 2006-03-09 Migenix, Inc. Compositions and methods for treating or preventing Hepadnaviridae infection
CA2583351A1 (en) * 2004-10-06 2006-04-13 Migenix Inc. Combination anti-viral compositions comprising castanospermine and methods of use
WO2008088581A2 (en) * 2006-08-02 2008-07-24 United Therapeutics Corporation Liposome treatment of viral infections
WO2009118658A2 (en) * 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
JP2012521981A (ja) * 2009-03-27 2012-09-20 ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード コレステロールレベル低下リポソーム
EP4106752A4 (en) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
ZA883925B (en) * 1987-06-08 1989-02-22 Merrell Dow Pharma Inhibitors of glycoprotein processing having anti-retroviral activity
CA1315276C (en) * 1987-07-02 1993-03-30 Paul S. Liu Castanospermine esters and glycosides
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis

Also Published As

Publication number Publication date
IE882933L (en) 1989-03-29
JPH01106821A (ja) 1989-04-24
DK538888A (da) 1989-03-30
EP0309952A3 (en) 1990-09-26
DK172788B1 (da) 1999-07-19
DE3850335T2 (de) 1994-10-13
JP2761898B2 (ja) 1998-06-04
IE64311B1 (en) 1995-07-26
ATE107506T1 (de) 1994-07-15
EP0309952B1 (en) 1994-06-22
DK538888D0 (da) 1988-09-28
ZA887160B (en) 1989-05-30
KR890004701A (ko) 1989-05-09
AU2280288A (en) 1989-04-06
DE3850335D1 (de) 1994-07-28
US5004746A (en) 1991-04-02
PH24431A (en) 1990-06-25
ES2058201T3 (es) 1994-11-01
EP0309952A2 (en) 1989-04-05
AU614993B2 (en) 1991-09-19

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