DK172647B1 - Samling af polypeptider og samling af antistoffer, som er karakteristiske for papillomavirus, og diagnostiske metoder, hvor - Google Patents
Samling af polypeptider og samling af antistoffer, som er karakteristiske for papillomavirus, og diagnostiske metoder, hvor Download PDFInfo
- Publication number
- DK172647B1 DK172647B1 DK198702089A DK208987A DK172647B1 DK 172647 B1 DK172647 B1 DK 172647B1 DK 198702089 A DK198702089 A DK 198702089A DK 208987 A DK208987 A DK 208987A DK 172647 B1 DK172647 B1 DK 172647B1
- Authority
- DK
- Denmark
- Prior art keywords
- hpv
- nos
- cncm
- papillomaviruses
- compositions
- Prior art date
Links
- 241001631646 Papillomaviridae Species 0.000 title claims abstract description 53
- 229920001184 polypeptide Polymers 0.000 title claims description 30
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 30
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 30
- 238000002405 diagnostic procedure Methods 0.000 title description 5
- 238000000034 method Methods 0.000 claims abstract description 31
- 238000000338 in vitro Methods 0.000 claims abstract description 6
- 238000003745 diagnosis Methods 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 54
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 claims description 51
- 230000008696 hypoxemic pulmonary vasoconstriction Effects 0.000 claims description 51
- 239000000203 mixture Substances 0.000 claims description 22
- 239000012634 fragment Substances 0.000 claims description 15
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims description 15
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 108700026244 Open Reading Frames Proteins 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 5
- 230000037029 cross reaction Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 101150027802 L2 gene Proteins 0.000 claims description 3
- 230000002380 cytological effect Effects 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
- 108020004414 DNA Proteins 0.000 abstract description 15
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract description 3
- 239000000523 sample Substances 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 description 31
- 239000013612 plasmid Substances 0.000 description 27
- 239000000047 product Substances 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 22
- 241000700605 Viruses Species 0.000 description 19
- 239000000427 antigen Substances 0.000 description 19
- 210000002966 serum Anatomy 0.000 description 18
- 102000036639 antigens Human genes 0.000 description 16
- 108091007433 antigens Proteins 0.000 description 16
- 238000004458 analytical method Methods 0.000 description 8
- 102000037865 fusion proteins Human genes 0.000 description 7
- 108020001507 fusion proteins Proteins 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 239000006166 lysate Substances 0.000 description 6
- 101100342726 Mus musculus Lats1 gene Proteins 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000001262 western blot Methods 0.000 description 5
- 208000000260 Warts Diseases 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000002458 infectious effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229920002401 polyacrylamide Polymers 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 210000002845 virion Anatomy 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 3
- 102000002464 Galactosidases Human genes 0.000 description 3
- 108010093031 Galactosidases Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 210000004897 n-terminal region Anatomy 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000701959 Escherichia virus Lambda Species 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 230000000951 immunodiffusion Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- HKJKONMZMPUGHJ-UHFFFAOYSA-N 4-amino-5-hydroxy-3-[(4-nitrophenyl)diazenyl]-6-phenyldiazenylnaphthalene-2,7-disulfonic acid Chemical compound OS(=O)(=O)C1=CC2=CC(S(O)(=O)=O)=C(N=NC=3C=CC=CC=3)C(O)=C2C(N)=C1N=NC1=CC=C([N+]([O-])=O)C=C1 HKJKONMZMPUGHJ-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 239000005278 LISON - lithium–sulfur oxynitride Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 101150054175 cro gene Proteins 0.000 description 1
- 230000010460 detection of virus Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 201000004306 epidermodysplasia verruciformis Diseases 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8512750 | 1985-08-26 | ||
| FR8512750A FR2586428B1 (fr) | 1985-08-26 | 1985-08-26 | Polypeptides et anticorps, caracteristiques du papillomavirus et leurs applications au diagnostic in vitro, a la prevention et/ou la lutte contre des infections a papillomavirus |
| FR8600288 | 1986-08-22 | ||
| PCT/FR1986/000288 WO1987001375A1 (fr) | 1985-08-26 | 1986-08-22 | Polypeptides et anticorps caracteristiques du papillomavirus, methodes de diagnostic et vaccins les utilisant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK208987D0 DK208987D0 (da) | 1987-04-24 |
| DK208987A DK208987A (da) | 1987-06-26 |
| DK172647B1 true DK172647B1 (da) | 1999-04-06 |
Family
ID=9322402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198702089A DK172647B1 (da) | 1985-08-26 | 1987-04-24 | Samling af polypeptider og samling af antistoffer, som er karakteristiske for papillomavirus, og diagnostiske metoder, hvor |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5955260A (ja) |
| EP (1) | EP0235187B1 (ja) |
| JP (4) | JP2755574B2 (ja) |
| AT (1) | ATE70280T1 (ja) |
| CA (1) | CA1279276C (ja) |
| DE (1) | DE3682893D1 (ja) |
| DK (1) | DK172647B1 (ja) |
| ES (1) | ES2003339A6 (ja) |
| FR (1) | FR2586428B1 (ja) |
| GR (1) | GR862201B (ja) |
| PT (1) | PT83255B (ja) |
| WO (1) | WO1987001375A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3779175D1 (de) * | 1986-03-21 | 1992-06-25 | Pasteur Institut | Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen. |
| DE3625257A1 (de) * | 1986-07-23 | 1988-02-04 | Behringwerke Ag | Expressionsprodukte der menschlichen papillomviren typ 16 und 18, fuer diese proteine spezifische antikoerper und diese antikoerper bzw. entsprechende dna enthaltende diagnostika |
| FR2631341B1 (fr) * | 1988-05-13 | 1991-04-26 | Pasteur Institut | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55 et produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55 et procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
| FR2632956B2 (fr) * | 1988-05-13 | 1991-07-12 | Pasteur Institut | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
| SE8803870D0 (sv) * | 1988-10-28 | 1988-10-28 | Medscand Ab | Method for detection of human papillomavirus (hpv) for diagnostic purposes |
| FR2641081A1 (ja) * | 1988-12-23 | 1990-06-29 | Medgenix Group | |
| FR2656627B1 (fr) * | 1989-12-28 | 1992-04-17 | Pasteur Institut | Sonde a papillomavirus (hvpv63), notamment pour le diagnostic in vitro d'infections a papillomavirus, pouvant s'accompagner de neoplasies genitales, et produits genetiquement et immunologiquement lies a ce papillomavirus. |
| SE9001705D0 (sv) * | 1990-05-11 | 1990-05-11 | Medscand Ab | Saett foer diagnostik av virusbaerande tumoerer genom immunoassay |
| US5932412A (en) * | 1990-05-11 | 1999-08-03 | Euro-Diagnostica Ab | Synthetic peptides in human papillomaviruses 1, 5, 6, 8, 11, 16, 18, 31, 33 and 56, useful in immunoassay for diagnostic purposes |
| FR2661921B1 (fr) * | 1990-05-11 | 1992-08-07 | Pasteur Institut | Sonde a papillomavirus (hpv66), notamment pour le diagnostic in vitro d'infections a papillomavirus, pouvant s'accompagner de neoplasies genitales, et produits genetiquement et immunologiquement lies a ce papillomavirus. |
| WO1995031532A1 (en) * | 1994-05-16 | 1995-11-23 | Merck & Co., Inc. | Papillomavirus vaccines |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| AU2001251394A1 (en) * | 2000-04-05 | 2001-10-23 | Impact Diagnostics, Inc. | Immunological methodology for discerning human papillomavirus |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| EP1425039A4 (en) | 2001-03-23 | 2005-02-02 | Us Gov Health & Human Serv | PEPTIDES THAT GIVE AN IMMUNE REACTION WITH THE HUMAN PAPILLOMA VIRUS |
| US6933123B2 (en) | 2001-04-05 | 2005-08-23 | Yao Xiong Hu | Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers |
| WO2005063286A1 (en) * | 2003-12-23 | 2005-07-14 | Arbor Vita Corporation | Antibodies for oncogenic strains of hpv and methods of their use |
| CA2573773A1 (en) * | 2004-07-15 | 2006-02-23 | Mastercard International Incorporated | Reference equipment for testing contactless payment devices |
| JP6046651B2 (ja) * | 2014-02-12 | 2016-12-21 | Ｎｅｃプラットフォームズ株式会社 | プログラム切替システム及びプログラム切替方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI64813C (fi) * | 1980-12-31 | 1984-01-10 | Ilkka Antero Palva | Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer |
| FR2524487B1 (fr) * | 1982-04-05 | 1985-11-22 | Pasteur Institut | Fragments d'adn codant pour des polypeptides contenant au moins un determinant antigenique des papillomavirus, notamment du type hpv 1a et polypeptides correspondants |
| US4514508A (en) * | 1982-07-06 | 1985-04-30 | Biond Inc. | Assaying for a multiplicity of antigens or antibodies with a detection compound |
| EP0133123A1 (en) * | 1983-07-25 | 1985-02-13 | Mgi Pharma, Inc. | Immunogens of papilloma viruses |
| CA1276575C (fr) * | 1984-11-30 | 1990-11-20 | Sylvie Beaudenon | Sondes a papillomavirus et procede de diagnostic in vitro d'infections a papillomavirus |
| EP0217919B1 (en) * | 1985-04-04 | 1992-08-05 | Georgetown University | Type-specific papillomavirus dna sequences and peptides |
| SE8803870D0 (sv) * | 1988-10-28 | 1988-10-28 | Medscand Ab | Method for detection of human papillomavirus (hpv) for diagnostic purposes |
-
1985
- 1985-08-26 FR FR8512750A patent/FR2586428B1/fr not_active Expired
-
1986
- 1986-08-22 AT AT86904851T patent/ATE70280T1/de not_active IP Right Cessation
- 1986-08-22 EP EP86904851A patent/EP0235187B1/fr not_active Expired - Lifetime
- 1986-08-22 JP JP61504468A patent/JP2755574B2/ja not_active Expired - Lifetime
- 1986-08-22 DE DE8686904851T patent/DE3682893D1/de not_active Expired - Lifetime
- 1986-08-22 WO PCT/FR1986/000288 patent/WO1987001375A1/fr active IP Right Grant
- 1986-08-25 ES ES8601326A patent/ES2003339A6/es not_active Expired
- 1986-08-26 CA CA000516841A patent/CA1279276C/fr not_active Expired - Lifetime
- 1986-08-26 PT PT83255A patent/PT83255B/pt unknown
- 1986-08-26 GR GR862201A patent/GR862201B/el unknown
-
1987
- 1987-04-24 DK DK198702089A patent/DK172647B1/da not_active IP Right Cessation
-
1995
- 1995-04-21 US US08/426,648 patent/US5955260A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,471 patent/US5919615A/en not_active Expired - Lifetime
- 1995-06-06 US US08/467,281 patent/US6010704A/en not_active Expired - Lifetime
-
1996
- 1996-04-30 JP JP8109988A patent/JP2818745B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-15 JP JP28238597A patent/JP3294787B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-22 JP JP10112334A patent/JP3067734B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2586428A1 (fr) | 1987-02-27 |
| JP3067734B2 (ja) | 2000-07-24 |
| US6010704A (en) | 2000-01-04 |
| EP0235187B1 (fr) | 1991-12-11 |
| US5919615A (en) | 1999-07-06 |
| JPH1123577A (ja) | 1999-01-29 |
| JPH08308597A (ja) | 1996-11-26 |
| PT83255B (pt) | 1989-07-31 |
| EP0235187A1 (fr) | 1987-09-09 |
| FR2586428B1 (fr) | 1988-11-25 |
| GR862201B (en) | 1986-12-23 |
| JPS63500662A (ja) | 1988-03-10 |
| CA1279276C (fr) | 1991-01-22 |
| JP2755574B2 (ja) | 1998-05-20 |
| US5955260A (en) | 1999-09-21 |
| ES2003339A6 (es) | 1988-11-01 |
| JPH10114677A (ja) | 1998-05-06 |
| PT83255A (en) | 1986-09-01 |
| DE3682893D1 (de) | 1992-01-23 |
| DK208987D0 (da) | 1987-04-24 |
| JP2818745B2 (ja) | 1998-10-30 |
| DK208987A (da) | 1987-06-26 |
| ATE70280T1 (de) | 1991-12-15 |
| JP3294787B2 (ja) | 2002-06-24 |
| WO1987001375A1 (fr) | 1987-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK172647B1 (da) | Samling af polypeptider og samling af antistoffer, som er karakteristiske for papillomavirus, og diagnostiske metoder, hvor | |
| JP2633275B2 (ja) | 乳頭腫ウイルス（ｈｐｖ）―３３のゲノムに由来するｄｎａ又はそのｄｎａ断片 | |
| EP0236145B1 (en) | Processes for the production of hcmv glycoproteins, antibodies thereto and hcmv vaccines, and recombinant vectors therefor | |
| JP3056502B2 (ja) | ヒトパピローマウイルス１６型のｅ７タンパク質上の免疫原性領域 | |
| Komly et al. | The L2 open reading frame of human papillomavirus type 1a encodes a minor structural protein carrying type-specific antigens | |
| US5656423A (en) | DNA sequences derived from the genome of the papillomavirus HPV39, their use in in vitro diagnosis and for the production of an immunogenic composition | |
| US5824466A (en) | Purified polypeptide of human papillomavirus type 49 (HPV49) type 50 (HVP50), and type 55 (HPV55) | |
| JPH07143888A (ja) | 型特異的乳頭腫ウイルスｄｎａ配列およびペプチド | |
| US6322794B1 (en) | Seroreactive epitopes on proteins of human papillomavirus (HPV) 18 | |
| US5045447A (en) | Method of producing antibodies to HPV | |
| Strike et al. | Expression in Escherichia coil of Seven DNA Fragments Comprising the Complete L1 and L2 Open Reading Frames of Human Papillomavirus Type 6b and Localization of the ‘Common Antigen’Region | |
| Matsuura et al. | Purification and characterization of human immunodeficiency virus type 1 nef gene product expressed by a recombinant baculovirus | |
| US5026636A (en) | Methods and compositions for production of mycoplasmal adhesins | |
| US6120989A (en) | Isolated human cytomegalovirus polypeptides and uses thereof | |
| CA2047142C (en) | Skin test to human papillomavirus type 16 | |
| US5885770A (en) | Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them | |
| CN112522210B (zh) | 一种分泌抗小反刍兽疫病毒单克隆抗体的杂交瘤细胞株及其单抗与应用 | |
| JPS63254983A (ja) | エイズの病原であるウイルスのｐ２５蛋白質をコードするウイルスベクター及び組換ＤＮＡ、感染された細胞培養物、得られる蛋白質、ワクチン及び得られる抗体 | |
| CN101914134B (zh) | 人乳头瘤58型病毒e7蛋白的线性抗原表位最小基序肽 | |
| CN117683083A (zh) | 一种识别牛结节性皮肤病病毒orf29蛋白的b细胞连续性线性及构象型抗原表位、抗原表位关键性氨基酸位点及其应用 | |
| CA1341329C (en) | Determined dna sequences derived from a papilloma virus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions | |
| JP4532614B2 (ja) | 水痘帯状疱疹ウイルス（ｖｚｖ）免疫反応性タンパク質ｖｐ２６およびその診断的使用 | |
| Moro et al. | Bacterial expression and immunological detection of human papillomavirus type 16 E7 protein | |
| WO1991004038A1 (en) | Antigen and immunoassay for human immunodeficiency virus type 2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |