DK172226B1 - Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater - Google Patents
Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater Download PDFInfo
- Publication number
- DK172226B1 DK172226B1 DK526188A DK526188A DK172226B1 DK 172226 B1 DK172226 B1 DK 172226B1 DK 526188 A DK526188 A DK 526188A DK 526188 A DK526188 A DK 526188A DK 172226 B1 DK172226 B1 DK 172226B1
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- methyl
- azabicyclo
- endo
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2199787 | 1987-09-23 | ||
| IT8721997A IT1231413B (it) | 1987-09-23 | 1987-09-23 | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK526188D0 DK526188D0 (da) | 1988-09-22 |
| DK526188A DK526188A (da) | 1989-03-24 |
| DK172226B1 true DK172226B1 (da) | 1998-01-12 |
Family
ID=11189966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK526188A DK172226B1 (da) | 1987-09-23 | 1988-09-22 | Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0309423B1 (xx) |
| JP (1) | JPH0631225B2 (xx) |
| KR (1) | KR960003604B1 (xx) |
| AT (1) | ATE107305T1 (xx) |
| BR (1) | BR1100514A (xx) |
| CA (1) | CA1337347C (xx) |
| CZ (1) | CZ279864B6 (xx) |
| DD (1) | DD285354A5 (xx) |
| DE (1) | DE3850203T2 (xx) |
| DK (1) | DK172226B1 (xx) |
| ES (1) | ES2054872T3 (xx) |
| FI (1) | FI89920C (xx) |
| HK (1) | HK142195A (xx) |
| HU (2) | HU200770B (xx) |
| IE (1) | IE63234B1 (xx) |
| IL (1) | IL87795A (xx) |
| IT (1) | IT1231413B (xx) |
| LV (1) | LV11035B (xx) |
| MX (1) | MX9203249A (xx) |
| NO (1) | NO169286C (xx) |
| NZ (1) | NZ226291A (xx) |
| PH (1) | PH29923A (xx) |
| PL (2) | PL152951B1 (xx) |
| SK (1) | SK630788A3 (xx) |
| SU (1) | SU1676451A3 (xx) |
| UA (1) | UA8022A1 (xx) |
| YU (1) | YU46925B (xx) |
| ZA (1) | ZA887083B (xx) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1230881B (it) * | 1989-06-20 | 1991-11-08 | Angeli Inst Spa | Derivati del r(-) 3-chinuclidinolo |
| CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
| EP0436245A1 (en) * | 1989-12-27 | 1991-07-10 | Duphar International Research B.V | Substituted 3,4-annelated benzimidazol-2(1H)-ones |
| JP3122671B2 (ja) * | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
| US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
| JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| IT1250629B (it) * | 1991-07-04 | 1995-04-21 | Boehringer Ingelheim Italia | Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico. |
| GB9204565D0 (en) * | 1992-03-03 | 1992-04-15 | Smithkline Beecham Plc | Pharmaceuticals |
| JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔３，２−ｂ〕ピリジン誘導体 |
| JPH05310732A (ja) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−３−カルボン酸誘導体 |
| US5763459A (en) * | 1992-05-23 | 1998-06-09 | Smithkline Beecham P.L.C. | Medicaments for the treatment of anxiety |
| US5300512A (en) * | 1992-06-24 | 1994-04-05 | G. D. Searle & Co. | Benzimidazole compounds |
| US5521193A (en) * | 1992-06-24 | 1996-05-28 | G. D. Searle & Co. | Benzimidazole compounds |
| US5280028A (en) * | 1992-06-24 | 1994-01-18 | G. D. Searle & Co. | Benzimidazole compounds |
| AU4350493A (en) * | 1992-06-27 | 1994-01-24 | Smithkline Beecham Plc | Medicaments containing 5-ht4 receptor antagonists |
| FR2694292B1 (fr) * | 1992-07-29 | 1994-10-21 | Esteve Labor Dr | Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament. |
| US5534521A (en) * | 1993-06-23 | 1996-07-09 | G. D. Searle & Co. | Benzimidazole compounds |
| GB9502582D0 (en) * | 1995-02-10 | 1995-03-29 | Smithkline Beecham Plc | Novel process |
| AU755117B2 (en) * | 1999-05-12 | 2002-12-05 | Sydney Gordon Low | A message processing system |
| TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| JP4129445B2 (ja) * | 2004-06-15 | 2008-08-06 | ファイザー・インク | ベンズイミダゾロンカルボン酸誘導体 |
| DE602005016446D1 (de) | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| ATE431824T1 (de) | 2004-11-05 | 2009-06-15 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
| CN101080406A (zh) | 2004-12-22 | 2007-11-28 | 施万制药 | 吲唑－甲酰胺化合物 |
| JP5042043B2 (ja) | 2005-03-02 | 2012-10-03 | セラヴァンス， インコーポレーテッド | ５−ｈｔ４レセプターアゴニストであるキノリン化合物 |
| DE602006019595D1 (de) | 2005-06-07 | 2011-02-24 | Theravance Inc | Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors |
| MY143574A (en) | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
| WO2009016564A2 (en) * | 2007-07-27 | 2009-02-05 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[3.3.0]octane derivatives |
| ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| ES2664599T3 (es) | 2009-05-20 | 2018-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales |
| EP2712655B1 (en) | 2011-04-28 | 2019-12-18 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9790184B2 (en) | 2012-07-27 | 2017-10-17 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| WO2016007630A1 (en) * | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250176A (en) * | 1976-12-21 | 1981-02-10 | Janssen Pharmaceutica N.V. | Piperazine derivatives |
| EP0093488A3 (en) * | 1982-03-18 | 1984-05-23 | Beecham Group Plc | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them |
| ES2053451T3 (es) * | 1986-01-07 | 1994-08-01 | Beecham Group Plc | Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles. |
-
1987
- 1987-09-23 IT IT8721997A patent/IT1231413B/it active
-
1988
- 1988-09-19 DE DE3850203T patent/DE3850203T2/de not_active Expired - Lifetime
- 1988-09-19 AT AT88830375T patent/ATE107305T1/de not_active IP Right Cessation
- 1988-09-19 DD DD88319929A patent/DD285354A5/de not_active IP Right Cessation
- 1988-09-19 PL PL1988279346A patent/PL152951B1/pl unknown
- 1988-09-19 IL IL87795A patent/IL87795A/xx active Protection Beyond IP Right Term
- 1988-09-19 EP EP88830375A patent/EP0309423B1/en not_active Expired - Lifetime
- 1988-09-19 ES ES88830375T patent/ES2054872T3/es not_active Expired - Lifetime
- 1988-09-19 PL PL1988274751A patent/PL151434B1/pl unknown
- 1988-09-20 CA CA000577840A patent/CA1337347C/en not_active Expired - Lifetime
- 1988-09-20 JP JP63236179A patent/JPH0631225B2/ja not_active Expired - Lifetime
- 1988-09-21 YU YU177888A patent/YU46925B/sh unknown
- 1988-09-21 NZ NZ226291A patent/NZ226291A/xx unknown
- 1988-09-22 NO NO884202A patent/NO169286C/no not_active IP Right Cessation
- 1988-09-22 CZ CS886307A patent/CZ279864B6/cs not_active IP Right Cessation
- 1988-09-22 DK DK526188A patent/DK172226B1/da not_active IP Right Cessation
- 1988-09-22 FI FI884350A patent/FI89920C/fi not_active IP Right Cessation
- 1988-09-22 SU SU884356601A patent/SU1676451A3/ru active
- 1988-09-22 HU HU884970A patent/HU200770B/hu not_active IP Right Cessation
- 1988-09-22 PH PH37579A patent/PH29923A/en unknown
- 1988-09-22 UA UA4356601A patent/UA8022A1/uk unknown
- 1988-09-22 IE IE286988A patent/IE63234B1/en not_active IP Right Cessation
- 1988-09-22 ZA ZA887083A patent/ZA887083B/xx unknown
- 1988-09-22 SK SK6307-88A patent/SK630788A3/sk unknown
- 1988-09-23 KR KR88012299A patent/KR960003604B1/ko not_active IP Right Cessation
-
1992
- 1992-06-24 MX MX9203249A patent/MX9203249A/es unknown
-
1995
- 1995-02-17 LV LVP-95-33A patent/LV11035B/en unknown
- 1995-06-30 HU HU95P/P00691P patent/HU211566A9/hu unknown
- 1995-09-07 HK HK142195A patent/HK142195A/xx not_active IP Right Cessation
-
1997
- 1997-05-13 BR BR1100514-9A patent/BR1100514A/pt active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |