DK172226B1 - Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater - Google Patents

Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater Download PDF

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Publication number
DK172226B1
DK172226B1 DK526188A DK526188A DK172226B1 DK 172226 B1 DK172226 B1 DK 172226B1 DK 526188 A DK526188 A DK 526188A DK 526188 A DK526188 A DK 526188A DK 172226 B1 DK172226 B1 DK 172226B1
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Prior art keywords
alkyl
methyl
azabicyclo
endo
compound
Prior art date
Application number
DK526188A
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Danish (da)
English (en)
Other versions
DK526188A (da
DK526188D0 (da
Inventor
Marco Turconi
Arturo Donetti
Rosamaria Micheletti
Annamaria Uberti
Massimo Nicola
Antonio Giachetti
Ernesto Montagna
Original Assignee
Boehringer Ingelheim Italia
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Publication date
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of DK526188D0 publication Critical patent/DK526188D0/da
Publication of DK526188A publication Critical patent/DK526188A/da
Application granted granted Critical
Publication of DK172226B1 publication Critical patent/DK172226B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK526188A 1987-09-23 1988-09-22 Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater DK172226B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2199787 1987-09-23
IT8721997A IT1231413B (it) 1987-09-23 1987-09-23 Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht

Publications (3)

Publication Number Publication Date
DK526188D0 DK526188D0 (da) 1988-09-22
DK526188A DK526188A (da) 1989-03-24
DK172226B1 true DK172226B1 (da) 1998-01-12

Family

ID=11189966

Family Applications (1)

Application Number Title Priority Date Filing Date
DK526188A DK172226B1 (da) 1987-09-23 1988-09-22 Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater

Country Status (28)

Country Link
EP (1) EP0309423B1 (ja)
JP (1) JPH0631225B2 (ja)
KR (1) KR960003604B1 (ja)
AT (1) ATE107305T1 (ja)
BR (1) BR1100514A (ja)
CA (1) CA1337347C (ja)
CZ (1) CZ279864B6 (ja)
DD (1) DD285354A5 (ja)
DE (1) DE3850203T2 (ja)
DK (1) DK172226B1 (ja)
ES (1) ES2054872T3 (ja)
FI (1) FI89920C (ja)
HK (1) HK142195A (ja)
HU (2) HU200770B (ja)
IE (1) IE63234B1 (ja)
IL (1) IL87795A (ja)
IT (1) IT1231413B (ja)
LV (1) LV11035B (ja)
MX (1) MX9203249A (ja)
NO (1) NO169286C (ja)
NZ (1) NZ226291A (ja)
PH (1) PH29923A (ja)
PL (2) PL152951B1 (ja)
SK (1) SK630788A3 (ja)
SU (1) SU1676451A3 (ja)
UA (1) UA8022A1 (ja)
YU (1) YU46925B (ja)
ZA (1) ZA887083B (ja)

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IT1230881B (it) * 1989-06-20 1991-11-08 Angeli Inst Spa Derivati del r(-) 3-chinuclidinolo
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
EP0436245A1 (en) * 1989-12-27 1991-07-10 Duphar International Research B.V Substituted 3,4-annelated benzimidazol-2(1H)-ones
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
IT1250629B (it) * 1991-07-04 1995-04-21 Boehringer Ingelheim Italia Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
GB9204565D0 (en) * 1992-03-03 1992-04-15 Smithkline Beecham Plc Pharmaceuticals
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
AU4081393A (en) * 1992-05-23 1993-12-30 Smithkline Beecham Plc Medicaments for the treatment of anxiety
US5300512A (en) * 1992-06-24 1994-04-05 G. D. Searle & Co. Benzimidazole compounds
US5521193A (en) * 1992-06-24 1996-05-28 G. D. Searle & Co. Benzimidazole compounds
US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
WO1994000113A2 (en) * 1992-06-27 1994-01-06 Smithkline Beecham Plc Medicaments containing 5-ht4 receptor antagonists
FR2694292B1 (fr) * 1992-07-29 1994-10-21 Esteve Labor Dr Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament.
US5534521A (en) * 1993-06-23 1996-07-09 G. D. Searle & Co. Benzimidazole compounds
GB9502582D0 (en) * 1995-02-10 1995-03-29 Smithkline Beecham Plc Novel process
AU755117B2 (en) * 1999-05-12 2002-12-05 Sydney Gordon Low A message processing system
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
JP4129445B2 (ja) * 2004-06-15 2008-08-06 ファイザー・インク ベンズイミダゾロンカルボン酸誘導体
JP5086091B2 (ja) 2004-11-05 2012-11-28 セラヴァンス， インコーポレーテッド ５−ｈｔ４受容体アゴニスト化合物
JP5042028B2 (ja) 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
JP5159317B2 (ja) 2004-12-22 2013-03-06 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物
WO2006094063A1 (en) 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
EP1902053B1 (en) 2005-06-07 2011-01-12 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists
MY143574A (en) 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
BRPI0814593A2 (pt) * 2007-07-27 2015-01-20 Actelion Pharmaceuticals Ltd Composto, composição farmacêutica que o contém e uso do composto.
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
US8580730B2 (en) 2009-05-20 2013-11-12 (Inserm) Institut National De La Sante Et De La Recherche Medicale Methods of treating lesional vestibular disorders by administering serotonin 5-HT3 receptor antagonists
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
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US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
TW201617342A (zh) * 2014-07-11 2016-05-16 阿法馬根公司 調節α７活性之啶類

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Also Published As

Publication number Publication date
SK278812B6 (sk) 1998-03-04
MX9203249A (es) 1992-07-01
PL151434B1 (en) 1990-09-28
YU46925B (sh) 1994-06-24
HU211566A9 (en) 1995-12-28
UA8022A1 (uk) 1995-12-26
FI89920C (fi) 1993-12-10
YU177888A (en) 1990-06-30
FI89920B (fi) 1993-08-31
JPH01106882A (ja) 1989-04-24
DK526188A (da) 1989-03-24
IE882869L (en) 1989-03-23
FI884350A0 (fi) 1988-09-22
NO169286B (no) 1992-02-24
NO169286C (no) 1992-06-03
SK630788A3 (en) 1998-03-04
IL87795A (en) 1993-02-21
HU200770B (en) 1990-08-28
PH29923A (en) 1996-09-16
CA1337347C (en) 1995-10-17
EP0309423A3 (en) 1989-11-29
BR1100514A (pt) 2002-04-02
IT8721997A0 (it) 1987-09-23
IE63234B1 (en) 1995-04-05
KR960003604B1 (en) 1996-03-20
JPH0631225B2 (ja) 1994-04-27
PL279346A1 (en) 1990-01-08
ATE107305T1 (de) 1994-07-15
FI884350A (fi) 1989-03-24
DE3850203D1 (de) 1994-07-21
DK526188D0 (da) 1988-09-22
NO884202D0 (no) 1988-09-22
KR890005105A (ko) 1989-05-11
HK142195A (en) 1995-09-15
NZ226291A (en) 1991-05-28
NO884202L (no) 1989-03-28
AU2237888A (en) 1989-03-23
AU610040B2 (en) 1991-05-09
SU1676451A3 (ru) 1991-09-07
DD285354A5 (de) 1990-12-12
LV11035A (lv) 1996-02-20
DE3850203T2 (de) 1994-09-22
CZ630788A3 (en) 1995-04-12
EP0309423B1 (en) 1994-06-15
CZ279864B6 (cs) 1995-07-12
ZA887083B (en) 1990-05-30
ES2054872T3 (es) 1994-08-16
PL152951B1 (en) 1991-02-28
IL87795A0 (en) 1989-03-31
EP0309423A2 (en) 1989-03-29
PL274751A1 (en) 1989-09-04
HUT48250A (en) 1989-05-29
LV11035B (en) 1996-08-20
IT1231413B (it) 1991-12-04

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired