DK170819B1 - Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse - Google Patents

Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse Download PDF

Info

Publication number
DK170819B1
DK170819B1 DK307286A DK307286A DK170819B1 DK 170819 B1 DK170819 B1 DK 170819B1 DK 307286 A DK307286 A DK 307286A DK 307286 A DK307286 A DK 307286A DK 170819 B1 DK170819 B1 DK 170819B1
Authority
DK
Denmark
Prior art keywords
compound
methoxy
methylthio
formula
methylsulfinyl
Prior art date
Application number
DK307286A
Other languages
Danish (da)
English (en)
Other versions
DK307286D0 (da
DK307286A (da
Inventor
Akira Nohara
Yoshitaka Maki
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK307286D0 publication Critical patent/DK307286D0/da
Publication of DK307286A publication Critical patent/DK307286A/da
Application granted granted Critical
Publication of DK170819B1 publication Critical patent/DK170819B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK307286A 1985-07-02 1986-06-27 Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse DK170819B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14639585 1985-07-02
JP14639585 1985-07-02
JP16045785 1985-07-19
JP16045785 1985-07-19

Publications (3)

Publication Number Publication Date
DK307286D0 DK307286D0 (da) 1986-06-27
DK307286A DK307286A (da) 1987-01-03
DK170819B1 true DK170819B1 (da) 1996-01-29

Family

ID=26477257

Family Applications (1)

Application Number Title Priority Date Filing Date
DK307286A DK170819B1 (da) 1985-07-02 1986-06-27 Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse

Country Status (11)

Country Link
US (1) US4738975A (fr)
EP (1) EP0208452B1 (fr)
JP (1) JPH0674270B2 (fr)
KR (1) KR930010495B1 (fr)
CN (1) CN1018642B (fr)
AT (1) ATE67494T1 (fr)
CA (1) CA1339819C (fr)
DE (1) DE3681518D1 (fr)
DK (1) DK170819B1 (fr)
HU (1) HUT43589A (fr)
IE (1) IE59049B1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
ZA889194B (en) * 1987-12-11 1989-08-30 Byk Gulden Lomberg Chemisch Fa Novel benzimidazole derivatives
KR920003928B1 (ko) * 1988-09-20 1992-05-18 히사미쯔세이야꾸 가부시기가이샤 신규의 디벤즈[b,e]옥세핀유도체
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
SE8804628D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New compounds
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
GR1001241B (el) * 1989-05-19 1993-06-30 Byk Gulden Lomberg Chem Fab Μεθοδος αλκυλιωσεως.
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
PL166209B1 (pl) * 1990-06-20 1995-04-28 Astra Ab Sposób wytwarzania nowych pochodnych benzimidazolu PL
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
AT394368B (de) * 1990-08-07 1992-03-25 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von 3,4-dialkoxypyridinen
EP0481764B1 (fr) * 1990-10-17 2000-03-29 Takeda Chemical Industries, Ltd. Dérivés de pyridine, leur préparation et utilisation
US5298525A (en) * 1992-11-23 1994-03-29 University Technologies International, Inc. Diabetes prevention and treatment
TW280770B (fr) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
AU6551198A (en) * 1997-05-30 1998-12-30 Dr. Reddy's Research Foundation Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
US6328994B1 (en) 1998-05-18 2001-12-11 Takeda Chemical Industries, Ltd. Orally disintegrable tablets
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
CA2445513A1 (fr) * 2001-09-18 2003-03-27 Zeria Pharmaceutical Co., Ltd. Derives de benzimidazole
MXPA06002443A (es) * 2003-09-03 2006-08-31 Agi Therapeutics Ltd Formulaciones inhibidoras de la bomba de protones y metodos para preparar y utilizar tales formulaciones.
JP5053865B2 (ja) 2005-12-28 2012-10-24 武田薬品工業株式会社 口腔内崩壊性固形製剤の製造法
PT2124884T (pt) 2006-12-22 2019-09-17 Ironwood Pharmaceuticals Inc Composições compreendendo sequestradores de ácido biliar para tratar distúrbios esofágicos
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
AU2014207680B2 (en) 2013-01-15 2018-09-06 Ironwood Pharmaceuticals, Inc. Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant
WO2016126625A1 (fr) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Méthodes de traitement de troubles gastro-intestinaux supérieurs de gerd réfractaire à ppi
EP3288556A4 (fr) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
KR930010495B1 (ko) 1993-10-25
EP0208452A2 (fr) 1987-01-14
HUT43589A (en) 1987-11-30
IE59049B1 (en) 1993-12-15
EP0208452A3 (en) 1988-03-30
DE3681518D1 (de) 1991-10-24
ATE67494T1 (de) 1991-10-15
IE861675L (en) 1987-01-02
JPH0674270B2 (ja) 1994-09-21
JPS62116576A (ja) 1987-05-28
CN86104636A (zh) 1987-01-28
KR870001195A (ko) 1987-03-12
DK307286D0 (da) 1986-06-27
EP0208452B1 (fr) 1991-09-18
DK307286A (da) 1987-01-03
US4738975A (en) 1988-04-19
CA1339819C (fr) 1998-04-14
CN1018642B (zh) 1992-10-14

Similar Documents

Publication Publication Date Title
DK170819B1 (da) Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse
US4689333A (en) 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles
EP0654471B1 (fr) Dérivés de pyridine, compositions pharmaceutiques les contenant, leur utilisation pour le préparation de médicaments de valeur thérapeutique ou préventive et procédé pour leur préparation
US4555518A (en) Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
EP0175464B1 (fr) Dérivés de benzimidazole et leur préparation
AU2006274037B2 (en) Isotopically substituted pantoprazole
NO822686L (no) Nye farmasoeytiske blandinger.
JPH0338247B2 (fr)
CA2053527C (fr) Derives de la pyridine, leur production et leur utilisation
JPH0313234B2 (fr)
CZ420498A3 (cs) Indolinový derivát jako antagonista 5-HT-2C receptoru
US4791114A (en) 2-Benzimidazolylalkylthio (or -sulfinyl or -sulfonyl) derivatives, their preparation and their application as medicinal products
HU196997B (en) Process for producing pyridine derivatives and pharmaceuticals comprising these compounds as active ingredient
JPH05112559A (ja) ４−アミノ−５−ピリミジンカルボン酸誘導体
IE904248A1 (en) Therapeutically active fluoro substituted benzimidazoles,¹processes for their preparation as well as their use
JPH01121274A (ja) ２−置換シクロヘプトイミダゾール誘導体、抗潰瘍剤並びにその製法
JPH0559043A (ja) ピリジン誘導体およびその製造法
JPH01121271A (ja) ２−置換シクロヘプトイミダゾール誘導体、抗潰瘍剤並びにその製造方法

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK