DK169703B1 - Pyrimidinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse samt anvendelse af disse derivater til fremstilling af et lægemiddel til antitumor- eller cancerterapi - Google Patents

Pyrimidinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse samt anvendelse af disse derivater til fremstilling af et lægemiddel til antitumor- eller cancerterapi Download PDF

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Publication number
DK169703B1
DK169703B1 DK158589A DK158589A DK169703B1 DK 169703 B1 DK169703 B1 DK 169703B1 DK 158589 A DK158589 A DK 158589A DK 158589 A DK158589 A DK 158589A DK 169703 B1 DK169703 B1 DK 169703B1
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DK
Denmark
Prior art keywords
benzoyl
propyl
compound
group
amino
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Application number
DK158589A
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Danish (da)
English (en)
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DK158589D0 (da
DK158589A (da
Inventor
Hiroaki Nomura
Hiroshi Akimoto
Tetsuo Miwa
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Takeda Chemical Industries Ltd
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Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK158589D0 publication Critical patent/DK158589D0/da
Publication of DK158589A publication Critical patent/DK158589A/da
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Publication of DK169703B1 publication Critical patent/DK169703B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK158589A 1988-04-01 1989-03-31 Pyrimidinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse samt anvendelse af disse derivater til fremstilling af et lægemiddel til antitumor- eller cancerterapi DK169703B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8204388 1988-04-01
JP8204388 1988-04-01
JP1028120A JP2830008B2 (ja) 1988-04-01 1989-02-06 縮合ピリミジン誘導体
JP2812089 1989-02-06

Publications (3)

Publication Number Publication Date
DK158589D0 DK158589D0 (da) 1989-03-31
DK158589A DK158589A (da) 1989-10-02
DK169703B1 true DK169703B1 (da) 1995-01-16

Family

ID=26366158

Family Applications (1)

Application Number Title Priority Date Filing Date
DK158589A DK169703B1 (da) 1988-04-01 1989-03-31 Pyrimidinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse samt anvendelse af disse derivater til fremstilling af et lægemiddel til antitumor- eller cancerterapi

Country Status (9)

Country Link
US (1) US4946846A (no)
EP (1) EP0340905B1 (no)
JP (1) JP2830008B2 (no)
KR (1) KR890016020A (no)
CN (1) CN1024007C (no)
DE (1) DE68911197T2 (no)
DK (1) DK169703B1 (no)
HU (2) HU908278D0 (no)
NO (1) NO169842C (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
US5243042A (en) * 1990-08-02 1993-09-07 Hoffmann-La Roche Inc. 1-thiaguanosine and process for preparing oxanosine and 1-thiaguanosine
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
ATE147386T1 (de) * 1991-08-12 1997-01-15 Takeda Chemical Industries Ltd Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
CZ66893A3 (en) * 1992-04-23 1993-12-15 Lilly Co Eli Application of gar - transformylase inhibitor
US5969136A (en) * 1992-10-15 1999-10-19 Eli Lilly And Company Cyclization for preparing antifolate compounds
US6268369B1 (en) 1994-11-16 2001-07-31 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
NZ297278A (en) 1994-11-16 1999-06-29 Synaptic Pharma Corp 4-aryl dihydropyrimidine derivatives end medicaments
US6228861B1 (en) 1995-11-16 2001-05-08 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6172066B1 (en) 1996-05-16 2001-01-09 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6245773B1 (en) 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US5912251A (en) * 1998-01-17 1999-06-15 Nair; Madhavan G. Metabolically inert anti-inflammatory and anti-tumor antifolates
US6274585B1 (en) 1998-12-23 2001-08-14 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6680323B2 (en) * 1998-12-23 2004-01-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6720324B2 (en) 2000-07-05 2004-04-13 Synaptic Pharmaceutical Corporation Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
CA2579096C (en) 2004-09-08 2012-11-13 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds
CA2674698A1 (en) 2007-01-19 2008-07-24 Chelsea Therapeutics, Inc. New classical antifolates
EP2496237A2 (en) 2009-11-06 2012-09-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US8658652B2 (en) 2010-12-07 2014-02-25 Chelsea Therapeutics, Inc. Antifolate combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2065653B (en) * 1979-12-19 1983-03-09 Nat Res Dev Anti-cancer quinazoline derivatives
DE3276808D1 (de) * 1981-09-25 1987-08-27 Southern Res Inst Pyrido (2,3-d) pyrimidines
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US4725687A (en) * 1986-04-28 1988-02-16 Southern Research Institute 5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds

Also Published As

Publication number Publication date
DK158589D0 (da) 1989-03-31
JP2830008B2 (ja) 1998-12-02
NO169842B (no) 1992-05-04
DE68911197T2 (de) 1994-04-14
HUT51620A (en) 1990-05-28
DK158589A (da) 1989-10-02
CN1024007C (zh) 1994-03-16
HU908278D0 (en) 1991-06-28
EP0340905A1 (en) 1989-11-08
US4946846A (en) 1990-08-07
KR890016020A (ko) 1989-11-28
CN1036567A (zh) 1989-10-25
NO891369D0 (no) 1989-03-31
JPH0228162A (ja) 1990-01-30
DE68911197D1 (de) 1994-01-20
NO891369L (no) 1989-10-02
NO169842C (no) 1992-08-12
HU203102B (en) 1991-05-28
EP0340905B1 (en) 1993-12-08

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B1 Patent granted (law 1993)
PBP Patent lapsed
PBP Patent lapsed