DK169435B1 - 2-Pyridyl-4-chinolylmethanderivater og fremgangsmåde til fremstilling af 2-pyridyl-4-chinolylketoner - Google Patents

2-Pyridyl-4-chinolylmethanderivater og fremgangsmåde til fremstilling af 2-pyridyl-4-chinolylketoner Download PDF

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Publication number
DK169435B1
DK169435B1 DK448981A DK448981A DK169435B1 DK 169435 B1 DK169435 B1 DK 169435B1 DK 448981 A DK448981 A DK 448981A DK 448981 A DK448981 A DK 448981A DK 169435 B1 DK169435 B1 DK 169435B1
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Prior art keywords
parts
pyridyl
trifluoromethyl
bis
preparation
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DK448981A
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Danish (da)
English (en)
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DK448981A (da
Inventor
Eckhard Hickmann
Heinz-Guenter Oeser
Original Assignee
Basf Ag
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Publication of DK448981A publication Critical patent/DK448981A/da
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Publication of DK169435B1 publication Critical patent/DK169435B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK448981A 1980-10-11 1981-10-09 2-Pyridyl-4-chinolylmethanderivater og fremgangsmåde til fremstilling af 2-pyridyl-4-chinolylketoner DK169435B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803038504 DE3038504A1 (de) 1980-10-11 1980-10-11 Neue 4-chinolinmethanderivate, ihre herstellung und verwendung zur darstellung von substanzen mit arzneimittelwirkung
DE3038504 1980-10-11

Publications (2)

Publication Number Publication Date
DK448981A DK448981A (da) 1982-04-12
DK169435B1 true DK169435B1 (da) 1994-10-31

Family

ID=6114192

Family Applications (1)

Application Number Title Priority Date Filing Date
DK448981A DK169435B1 (da) 1980-10-11 1981-10-09 2-Pyridyl-4-chinolylmethanderivater og fremgangsmåde til fremstilling af 2-pyridyl-4-chinolylketoner

Country Status (7)

Country Link
US (1) US4429130A (el)
EP (1) EP0049776B1 (el)
JP (1) JPS5793961A (el)
DE (2) DE3038504A1 (el)
DK (1) DK169435B1 (el)
GR (1) GR74977B (el)
HU (1) HU183612B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191508B (en) * 1982-12-02 1987-02-27 Alkaloida Vegyeszeti Gyar,Hu Process for preparing new chloromethyl-quinoline derivatives
HU188235B (en) * 1982-12-11 1986-03-28 Alkaloida Vegyeszeti Gyar,Hu Process for producing fluoro-methyl-quinoline derivatives
ATE55387T1 (de) * 1983-10-07 1990-08-15 Hoffmann La Roche Mefloquin-hydrochlorid.
CH667267A5 (de) * 1986-05-26 1988-09-30 Mepha Ag Verfahren zur herstellung von (2,8-bis-(trifluormethyl)-4-chinolyl)-2-pyridinyl-methanon.
HUT54363A (en) * 1989-07-25 1991-02-28 Alkaloida Vegyeszeti Gyar Process for producing pyridyl-methyl-quinolin derivatives
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
US6500955B1 (en) 2001-02-02 2002-12-31 National Institute Of Pharmaceutical Education And Research One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
US10963755B2 (en) 2016-09-20 2021-03-30 Mitsubishi Electric Corporation Interference identification device and interference identification method

Also Published As

Publication number Publication date
EP0049776A2 (de) 1982-04-21
DE3038504A1 (de) 1982-06-03
GR74977B (el) 1984-07-12
JPH0261473B2 (el) 1990-12-20
EP0049776B1 (de) 1985-07-31
DE3171591D1 (en) 1985-09-05
EP0049776A3 (en) 1982-05-19
US4429130A (en) 1984-01-31
DK448981A (da) 1982-04-12
JPS5793961A (en) 1982-06-11
HU183612B (en) 1984-05-28

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired