DK168790D0 - - Google Patents

Info

Publication number
DK168790D0
DK168790D0 DK168790A DK168790A DK168790D0 DK 168790 D0 DK168790 D0 DK 168790D0 DK 168790 A DK168790 A DK 168790A DK 168790 A DK168790 A DK 168790A DK 168790 D0 DK168790 D0 DK 168790D0
Authority
DK
Denmark
Prior art keywords
hgh
divalent cation
crystals
derivatives
growth factor
Prior art date
Application number
DK168790A
Other languages
Danish (da)
English (en)
Inventor
Flemming Junker
Claus Friis Theisen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK168790A priority Critical patent/DK168790D0/da
Publication of DK168790D0 publication Critical patent/DK168790D0/da
Priority to NZ238904A priority patent/NZ238904A/xx
Priority to PT98297A priority patent/PT98297B/pt
Priority to HU9300067A priority patent/HUT64086A/hu
Priority to RU93005051/13A priority patent/RU2108341C1/ru
Priority to DE69103755T priority patent/DE69103755T2/de
Priority to DK91913240.7T priority patent/DK0540582T3/da
Priority to ES91913240T priority patent/ES2060399T3/es
Priority to AU82846/91A priority patent/AU666465B2/en
Priority to EP91913240A priority patent/EP0540582B1/en
Priority to CA002086087A priority patent/CA2086087C/en
Priority to AT91913240T priority patent/ATE110745T1/de
Priority to HU9300067A priority patent/HU210323B/hu
Priority to PCT/DK1991/000203 priority patent/WO1992000998A1/en
Priority to IE244491A priority patent/IE67054B1/en
Priority to ZA915446A priority patent/ZA915446B/xx
Priority to JP3512511A priority patent/JP2524446B2/ja
Priority to BG97281A priority patent/BG61267B1/bg
Priority to US08/350,758 priority patent/US5780599A/en
Priority to US09/063,749 priority patent/US6117984A/en
Priority to US09/592,032 priority patent/US6894023B1/en
Priority to US11/130,433 priority patent/US20060116320A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
DK168790A 1990-07-13 1990-07-13 DK168790D0 (zh)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DK168790A DK168790D0 (zh) 1990-07-13 1990-07-13
NZ238904A NZ238904A (en) 1990-07-13 1991-07-10 Cation crystals of growth hormone and derivative; purification and pharmaceutical compositions
PT98297A PT98297B (pt) 1990-07-13 1991-07-11 Processo para a preparacao de cristais cationicos da hormona de crescimento
JP3512511A JP2524446B2 (ja) 1990-07-13 1991-07-12 成長ホルモン結晶及びこのようなｇｈ―結晶の製造方法
CA002086087A CA2086087C (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals
HU9300067A HU210323B (en) 1990-07-13 1991-07-12 Process for producing growth hormone crystals
DE69103755T DE69103755T2 (de) 1990-07-13 1991-07-12 Wachstumshormonkristalle und verfahren zu deren herstellung.
DK91913240.7T DK0540582T3 (da) 1990-07-13 1991-07-12 Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller
ES91913240T ES2060399T3 (es) 1990-07-13 1991-07-12 Cristales de la hormona del crecimiento y procedimiento para la produccion de estos cristales de la hormona del crecimiento.
AU82846/91A AU666465B2 (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these GH-crystals
EP91913240A EP0540582B1 (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals
HU9300067A HUT64086A (en) 1990-07-13 1991-07-12 Process for producing gh-crystals
AT91913240T ATE110745T1 (de) 1990-07-13 1991-07-12 Wachstumshormonkristalle und verfahren zu deren herstellung.
RU93005051/13A RU2108341C1 (ru) 1990-07-13 1991-07-12 Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат
PCT/DK1991/000203 WO1992000998A1 (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals
IE244491A IE67054B1 (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these GH-crystals
ZA915446A ZA915446B (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals
BG97281A BG61267B1 (en) 1990-07-13 1993-01-12 Growth hormone crystals and method for production thereof
US08/350,758 US5780599A (en) 1990-07-13 1994-12-07 Growth hormone crystals and a process for production of growth hormone crystals
US09/063,749 US6117984A (en) 1990-07-13 1998-04-21 Growth hormone crystals and a process for production of these GH-crystals
US09/592,032 US6894023B1 (en) 1990-07-13 2000-06-12 Growth hormone crystals and a process for production of these GH-crystals
US11/130,433 US20060116320A1 (en) 1990-07-13 2005-05-16 Growth hormone crystals and a process for production of these GH-crystals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK168790A DK168790D0 (zh) 1990-07-13 1990-07-13

Publications (1)

Publication Number Publication Date
DK168790D0 true DK168790D0 (zh) 1990-07-13

Family

ID=8107212

Family Applications (2)

Application Number Title Priority Date Filing Date
DK168790A DK168790D0 (zh) 1990-07-13 1990-07-13
DK91913240.7T DK0540582T3 (da) 1990-07-13 1991-07-12 Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK91913240.7T DK0540582T3 (da) 1990-07-13 1991-07-12 Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller

Country Status (17)

Country Link
US (1) US6117984A (zh)
EP (1) EP0540582B1 (zh)
JP (1) JP2524446B2 (zh)
AT (1) ATE110745T1 (zh)
AU (1) AU666465B2 (zh)
BG (1) BG61267B1 (zh)
CA (1) CA2086087C (zh)
DE (1) DE69103755T2 (zh)
DK (2) DK168790D0 (zh)
ES (1) ES2060399T3 (zh)
HU (2) HU210323B (zh)
IE (1) IE67054B1 (zh)
NZ (1) NZ238904A (zh)
PT (1) PT98297B (zh)
RU (1) RU2108341C1 (zh)
WO (1) WO1992000998A1 (zh)
ZA (1) ZA915446B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK168790D0 (zh) * 1990-07-13 1990-07-13 Novo Nordisk As
US6894023B1 (en) * 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
ATE227583T1 (de) * 1991-12-20 2002-11-15 Novo Nordisk As Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
US6197350B1 (en) 1996-12-20 2001-03-06 Takeda Chemical Industries, Ltd. Method of producing a sustained-release preparation
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物
US7101575B2 (en) 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6451347B1 (en) 1999-03-01 2002-09-17 Alkermes Controlled Therapeutics, Inc. Method for purifying human growth hormone
DE60000622T2 (de) 1999-06-10 2003-02-27 Max Planck Gesellschaft Einkapselung von kristallen mit mehrschichtigem überzug
US6566329B1 (en) 1999-06-28 2003-05-20 Novo Nordisk A/S Freeze-dried preparation of human growth hormone
EP1309312A2 (en) 2000-08-07 2003-05-14 Inhale Therapeutic Systems, Inc. Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
DE60136002D1 (de) 2000-10-06 2008-11-13 Pacira Pharmaceuticals Inc Parenteral verabreichbare mikropartikel-zubereitung mit kontrollierter freisetzung
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
SE0202719D0 (sv) * 2002-09-13 2002-09-13 Pharmacia Ab Process for mfg crystals of growth hormone
CN1744914A (zh) * 2002-12-31 2006-03-08 阿尔特斯制药公司 人生长激素晶体和制备它们的方法
SG176314A1 (en) 2002-12-31 2011-12-29 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them
EP1585771A4 (en) * 2002-12-31 2006-11-29 Altus Pharmaceuticals Inc COMPLEXES OF PROTEIN CRYSTALS AND IONIC POLYMERS
US20050032698A1 (en) * 2003-07-14 2005-02-10 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
JP2009521486A (ja) * 2005-12-23 2009-06-04 アルタス ファーマシューティカルズ インコーポレイテッド ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法
US8071544B2 (en) 2006-12-18 2011-12-06 Althea Technologies, Inc. Crystallized recombinant human growth factor formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA653324A (en) * 1962-12-04 G. Brink Norman Growth hormone and methods of preparing the same
US2143590A (en) * 1936-09-26 1939-01-10 Univ Alberta Insulin preparation and process of producing crystals of insulin
US2174862A (en) * 1938-12-30 1939-10-03 Frederick Stearns & Company Process of producing crystalline insulin
US2595278A (en) * 1950-04-28 1952-05-06 Armour & Co Preparation of insulin from pancreas glands
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
US2897117A (en) * 1955-02-10 1959-07-28 Univ Alberta Insulin process
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
KR890002631B1 (ko) * 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
EP0343696B1 (en) * 1984-10-04 1996-01-03 Monsanto Company Zinc-associated somatotropins
IL79681A (en) * 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
EP0277043A3 (en) * 1987-01-30 1989-08-23 IMCERA Group Inc. Method for recovering somatotropins from dilute aqueous solution
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
EP0355460B1 (en) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
DK168790D0 (zh) * 1990-07-13 1990-07-13 Novo Nordisk As
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals

Also Published As

Publication number Publication date
US6117984A (en) 2000-09-12
RU2108341C1 (ru) 1998-04-10
HU210323B (en) 1995-03-28
DE69103755D1 (de) 1994-10-06
ES2060399T3 (es) 1994-11-16
EP0540582A1 (en) 1993-05-12
ZA915446B (en) 1992-03-25
CA2086087A1 (en) 1992-01-14
JP2524446B2 (ja) 1996-08-14
DK0540582T3 (da) 1995-01-30
AU666465B2 (en) 1996-02-15
HUT64086A (en) 1993-11-29
IE912444A1 (en) 1992-01-15
WO1992000998A1 (en) 1992-01-23
NZ238904A (en) 1993-04-28
EP0540582B1 (en) 1994-08-31
AU8284691A (en) 1992-02-04
BG61267B1 (en) 1997-04-30
HU9300067D0 (en) 1993-04-28
PT98297A (pt) 1992-05-29
IE67054B1 (en) 1996-02-21
BG97281A (bg) 1994-03-24
DE69103755T2 (de) 1995-02-23
CA2086087C (en) 1999-09-14
JPH05507497A (ja) 1993-10-28
PT98297B (pt) 1999-01-29
ATE110745T1 (de) 1994-09-15

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
B1 Patent granted (law 1993)