DK168693B1 - Terapeutisk aktive konjugater med forbedret vævsbindingsspecificeret samt fremgangsmåde til fremstilling deraf - Google Patents
Terapeutisk aktive konjugater med forbedret vævsbindingsspecificeret samt fremgangsmåde til fremstilling deraf Download PDFInfo
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- DK168693B1 DK168693B1 DK420988A DK420988A DK168693B1 DK 168693 B1 DK168693 B1 DK 168693B1 DK 420988 A DK420988 A DK 420988A DK 420988 A DK420988 A DK 420988A DK 168693 B1 DK168693 B1 DK 168693B1
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- VUFGUVLLDPOSBC-XRZFDKQNSA-M cephalothin sodium Chemical compound [Na+].N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C([O-])=O)C(=O)CC1=CC=CS1 VUFGUVLLDPOSBC-XRZFDKQNSA-M 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
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- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical group O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
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- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
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- 239000008188 pellet Substances 0.000 description 1
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- 239000012071 phase Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000033885 plasminogen activation Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
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- 230000001681 protective effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229960002101 secretin Drugs 0.000 description 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 230000008409 synovial inflammation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868628398A GB8628398D0 (en) | 1986-11-27 | 1986-11-27 | Pharmaceutically-active conjugates |
GB8628398 | 1986-11-27 | ||
PCT/GB1987/000854 WO1988003810A1 (en) | 1986-11-27 | 1987-11-27 | Pharmaceutically active conjugates having improved body tissue binding specificity |
GB8700854 | 1987-11-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK420988A DK420988A (da) | 1988-07-27 |
DK420988D0 DK420988D0 (da) | 1988-07-27 |
DK168693B1 true DK168693B1 (da) | 1994-05-24 |
Family
ID=10608055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK420988A DK168693B1 (da) | 1986-11-27 | 1988-07-27 | Terapeutisk aktive konjugater med forbedret vævsbindingsspecificeret samt fremgangsmåde til fremstilling deraf |
Country Status (10)
Country | Link |
---|---|
US (1) | US5151412A (no) |
EP (1) | EP0333740B1 (no) |
JP (1) | JP2721830B2 (no) |
AT (1) | ATE68977T1 (no) |
AU (1) | AU610104B2 (no) |
DE (1) | DE3774279D1 (no) |
DK (1) | DK168693B1 (no) |
GB (1) | GB8628398D0 (no) |
NO (1) | NO177526C (no) |
WO (1) | WO1988003810A1 (no) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0340573A3 (de) * | 1988-04-30 | 1990-05-30 | BASF Aktiengesellschaft | Neue Proteine, ihre Herstellung und Verwendung |
US4892826A (en) * | 1988-10-11 | 1990-01-09 | Abbott Laboratories | Process for the preparation of urokinase derivatives |
US5654267A (en) * | 1988-12-20 | 1997-08-05 | La Jolla Cancer Research Center | Cooperative combinations of ligands contained within a matrix |
ATE135584T1 (de) * | 1988-12-20 | 1996-04-15 | Jolla Cancer Res Found | Polypeptid-polymer-konjugate mit wundheilender wirkung |
EP0429663A1 (en) * | 1989-06-13 | 1991-06-05 | Nippon Soda Co., Ltd. | Human prourokinase-like polypeptides and their preparation methods |
US5124320A (en) * | 1989-09-12 | 1992-06-23 | Ivy Jeffery W | An external analgesic lotion containing active ingredients of camphor and menthol and method of making such lotion |
US5013726A (en) * | 1989-09-12 | 1991-05-07 | Ivy Jeffery W | External analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol and method of making such lotion |
GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
GB9101183D0 (en) * | 1991-01-18 | 1991-02-27 | Univ London | Depot formulations |
CA2114629C (en) * | 1991-07-31 | 2003-01-14 | Howard C. Krivan | Receptor conjugates for targeting antibiotics to bacteria |
JP2829405B2 (ja) * | 1991-10-14 | 1998-11-25 | 寳酒造株式会社 | 機能性ポリペプチド |
CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
US5591719A (en) * | 1992-12-10 | 1997-01-07 | Regents Of The University Of Minnesota | Method for treating acute and chronic inflammatory disorders using polypeptides with fibronectin activity |
DE4242736A1 (de) * | 1992-12-17 | 1994-06-23 | Behringwerke Ag | Synthetische Peptide, Antikörper dagegen und ihre Verwendung |
WO1994016085A2 (en) * | 1992-12-30 | 1994-07-21 | Zymogenetics, Inc. | Hybrid proteins having cross-linking and tissue-binding activities |
WO1994017097A1 (en) * | 1993-01-19 | 1994-08-04 | Regents Of The University Of Minnesota | Synthetic fibronectin fragments as inhibitors of retroviral infections |
US5821074A (en) * | 1993-12-21 | 1998-10-13 | Abbott Laboratories | Method and compositions for enhancing aminolevulinic acid dehydratase assay |
CA2253204A1 (en) * | 1996-05-03 | 1997-11-13 | Roger S. Cubicciotti | Prodrug compositions and drug delivery methods using synthetic receptors |
EP1042367A1 (en) * | 1997-12-24 | 2000-10-11 | Immunex Corporation | V196 dna and polypeptides |
AU756913B2 (en) * | 1998-08-21 | 2003-01-23 | Immunex Corporation | Human IL-1 epsilon DNA and polypeptides |
IN190822B (no) * | 1998-12-24 | 2003-08-23 | Council Scient Ind Res | |
US7678767B2 (en) * | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US7553810B2 (en) | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
GB2116979B (en) * | 1982-02-25 | 1985-05-15 | Ward Page Faulk | Conjugates of proteins with anti-tumour agents |
IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
JPS59134732A (ja) * | 1983-01-21 | 1984-08-02 | Green Cross Corp:The | フイブロネクチン・生理活性物質複合体の製造法 |
JPS60226819A (ja) * | 1984-04-25 | 1985-11-12 | Green Cross Corp:The | フイブロネクチン複合体 |
WO1986001720A1 (en) * | 1984-09-13 | 1986-03-27 | Cytogen Corporation | Antibody therapeutic agent conjugates |
US4587122A (en) * | 1985-04-23 | 1986-05-06 | The Green Cross Corporation | Fibronectin-dextran-drug complex and method of preparation thereof |
-
1986
- 1986-11-27 GB GB868628398A patent/GB8628398D0/en active Pending
-
1987
- 1987-11-27 DE DE8787907789T patent/DE3774279D1/de not_active Expired - Fee Related
- 1987-11-27 AT AT87907789T patent/ATE68977T1/de active
- 1987-11-27 AU AU82773/87A patent/AU610104B2/en not_active Ceased
- 1987-11-27 EP EP87907789A patent/EP0333740B1/en not_active Expired - Lifetime
- 1987-11-27 JP JP63500074A patent/JP2721830B2/ja not_active Expired - Lifetime
- 1987-11-27 WO PCT/GB1987/000854 patent/WO1988003810A1/en active IP Right Grant
- 1987-11-27 US US07/359,662 patent/US5151412A/en not_active Expired - Fee Related
-
1988
- 1988-07-26 NO NO883306A patent/NO177526C/no unknown
- 1988-07-27 DK DK420988A patent/DK168693B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK420988A (da) | 1988-07-27 |
AU610104B2 (en) | 1991-05-16 |
EP0333740B1 (en) | 1991-10-30 |
JP2721830B2 (ja) | 1998-03-04 |
GB8628398D0 (en) | 1986-12-31 |
DK420988D0 (da) | 1988-07-27 |
US5151412A (en) | 1992-09-29 |
EP0333740A1 (en) | 1989-09-27 |
AU8277387A (en) | 1988-06-16 |
JPH02501305A (ja) | 1990-05-10 |
NO883306D0 (no) | 1988-07-26 |
NO177526C (no) | 1995-10-04 |
DE3774279D1 (de) | 1991-12-05 |
NO177526B (no) | 1995-06-26 |
NO883306L (no) | 1988-07-26 |
WO1988003810A1 (en) | 1988-06-02 |
ATE68977T1 (de) | 1991-11-15 |
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