DK1680681T3 - Fremgangsmåde og apparat til vurdering af polypeptidaggregering - Google Patents

Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Info

Publication number
DK1680681T3
DK1680681T3 DK04791642.4T DK04791642T DK1680681T3 DK 1680681 T3 DK1680681 T3 DK 1680681T3 DK 04791642 T DK04791642 T DK 04791642T DK 1680681 T3 DK1680681 T3 DK 1680681T3
Authority
DK
Denmark
Prior art keywords
aggregation
sequence
propensities
polypeptide aggregation
predicted
Prior art date
Application number
DK04791642.4T
Other languages
English (en)
Inventor
Christopher Dobson
Fabrizio Chiti
Jesus Zurdo
Kateri Hayashi Dubay
Michele Vendruscolo
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Application granted granted Critical
Publication of DK1680681T3 publication Critical patent/DK1680681T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04791642.4T 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering DK1680681T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0325817.5A GB0325817D0 (en) 2003-11-05 2003-11-05 Method and apparatus for assessing polypeptide aggregation
PCT/GB2004/050015 WO2005045442A1 (en) 2003-11-05 2004-10-01 Method and apparatus for assessing polypeptide aggregation

Publications (1)

Publication Number Publication Date
DK1680681T3 true DK1680681T3 (da) 2012-02-27

Family

ID=29725985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04791642.4T DK1680681T3 (da) 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Country Status (7)

Country Link
US (2) US7698070B2 (da)
EP (2) EP1680681B1 (da)
AT (1) ATE532072T1 (da)
DK (1) DK1680681T3 (da)
ES (1) ES2376463T3 (da)
GB (1) GB0325817D0 (da)
WO (1) WO2005045442A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004025669D1 (de) * 2003-01-20 2010-04-08 Cambridge Entpr Ltd Rechnerisches verfahren und vorrichtung zur vorhersage der polypeptidaggregation oder lösbarkeit
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation
JP2009545756A (ja) 2006-08-04 2009-12-24 ロンザ バイオロジックス ピーエルシー タンパク質凝集を予測し凝集阻害物質を設計する方法
WO2008074769A1 (en) * 2006-12-18 2008-06-26 Covalx Ag Direct mass spectrometric analysis of aggregates of therapeutic proteins
GB2455102A (en) * 2007-11-28 2009-06-03 Cambridge Entpr Ltd Protein Aggregation Prediction Systems
MX2010014062A (es) 2008-06-20 2011-02-22 Novartis Ag Metodos para identificar regiones de enlace a macromoleculas y con tendencia a la agregacion en proteinas y usos de las mismas.
CN102625813A (zh) 2008-06-20 2012-08-01 诺华公司 具有降低的聚集的免疫球蛋白
KR20180056805A (ko) 2009-06-04 2018-05-29 노파르티스 아게 ＩｇＧ 콘쥬게이션을 위한 자리의 확인 방법
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
US8717023B2 (en) * 2011-04-21 2014-05-06 Mark Griswold Relaxometry quantification self-justification fitting
WO2014022817A2 (en) 2012-08-03 2014-02-06 Novartis Ag Methods to identify amino acid residues involved in macromolecular binding and uses therefor
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
GB201809341D0 (en) * 2018-06-07 2018-07-25 Ucb Biopharma Sprl Multi-domain proteins with increased native state colloidal stability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751331B2 (en) * 1997-04-11 2002-08-15 California Institute Of Technology Apparatus and method for automated protein design
EP1255209A3 (en) 1997-04-11 2009-02-11 California Institute Of Technology Apparatus and method for automated protein design
JP2002526508A (ja) 1998-09-21 2002-08-20 イシス・イノベイシヨン・リミテツド フィブリル
GB9924484D0 (en) * 1999-10-15 1999-12-15 Isis Innovation Altered polypeptide aggregation
WO2002042321A2 (en) 2000-11-24 2002-05-30 Isis Innovation Limited Mixed fibrils
GB0109438D0 (en) 2001-04-17 2001-06-06 Isis Innovation Peptides
JP3802416B2 (ja) * 2001-12-27 2006-07-26 セレスター・レキシコ・サイエンシズ株式会社 相互作用部位予測装置、相互作用部位予測方法、プログラム、および、記録媒体
DE602004025669D1 (de) * 2003-01-20 2010-04-08 Cambridge Entpr Ltd Rechnerisches verfahren und vorrichtung zur vorhersage der polypeptidaggregation oder lösbarkeit
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation

Also Published As

Publication number Publication date
US20100261882A1 (en) 2010-10-14
WO2005045442A1 (en) 2005-05-19
ATE532072T1 (de) 2011-11-15
EP2261670B1 (en) 2014-08-20
EP1680681A1 (en) 2006-07-19
EP2261670A2 (en) 2010-12-15
US20060271306A1 (en) 2006-11-30
GB0325817D0 (en) 2003-12-10
EP1680681B1 (en) 2011-11-02
EP2261670A3 (en) 2011-03-23
US8155888B2 (en) 2012-04-10
ES2376463T3 (es) 2012-03-14
US7698070B2 (en) 2010-04-13

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