ATE532072T1 - Verfahren und vorrichtung zur beurteilung von polypeptidaggregation - Google Patents
Verfahren und vorrichtung zur beurteilung von polypeptidaggregationInfo
- Publication number
- ATE532072T1 ATE532072T1 AT04791642T AT04791642T ATE532072T1 AT E532072 T1 ATE532072 T1 AT E532072T1 AT 04791642 T AT04791642 T AT 04791642T AT 04791642 T AT04791642 T AT 04791642T AT E532072 T1 ATE532072 T1 AT E532072T1
- Authority
- AT
- Austria
- Prior art keywords
- aggregation
- sequence
- propensities
- polypeptide aggregation
- predicted
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0325817.5A GB0325817D0 (en) | 2003-11-05 | 2003-11-05 | Method and apparatus for assessing polypeptide aggregation |
| PCT/GB2004/050015 WO2005045442A1 (en) | 2003-11-05 | 2004-10-01 | Method and apparatus for assessing polypeptide aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532072T1 true ATE532072T1 (de) | 2011-11-15 |
Family
ID=29725985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04791642T ATE532072T1 (de) | 2003-11-05 | 2004-10-01 | Verfahren und vorrichtung zur beurteilung von polypeptidaggregation |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7698070B2 (de) |
| EP (2) | EP1680681B1 (de) |
| AT (1) | ATE532072T1 (de) |
| DK (1) | DK1680681T3 (de) |
| ES (1) | ES2376463T3 (de) |
| GB (1) | GB0325817D0 (de) |
| WO (1) | WO2005045442A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004025669D1 (de) | 2003-01-20 | 2010-04-08 | Cambridge Entpr Ltd | Rechnerisches verfahren und vorrichtung zur vorhersage der polypeptidaggregation oder lösbarkeit |
| GB0325817D0 (en) * | 2003-11-05 | 2003-12-10 | Univ Cambridge Tech | Method and apparatus for assessing polypeptide aggregation |
| US8290713B2 (en) | 2006-08-04 | 2012-10-16 | Lonza Biologics PLLC | Method for predicting protein aggregation and designing aggregation inhibitors |
| JP5302212B2 (ja) | 2006-12-18 | 2013-10-02 | コヴァルクス・アーゲー | 治療タンパク質の凝集体の直接質量分光分析 |
| GB2455102A (en) * | 2007-11-28 | 2009-06-03 | Cambridge Entpr Ltd | Protein Aggregation Prediction Systems |
| AU2009259906B2 (en) | 2008-06-20 | 2016-06-16 | Massachusetts Institute Of Technology | Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor |
| ES2669591T3 (es) * | 2008-06-20 | 2018-05-28 | Novartis Ag | Inmunoglobulinas con agregación reducida |
| ES2537566T3 (es) | 2009-06-04 | 2015-06-09 | Novartis Ag | Métodos para identificación de sitios para conjugación de IgG |
| GB0914691D0 (en) | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
| US8717023B2 (en) * | 2011-04-21 | 2014-05-06 | Mark Griswold | Relaxometry quantification self-justification fitting |
| US10431325B2 (en) | 2012-08-03 | 2019-10-01 | Novartis Ag | Methods to identify amino acid residues involved in macromolecular binding and uses therefor |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| KR20230076867A (ko) | 2013-12-20 | 2023-05-31 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신생항원 백신과의 병용 요법 |
| WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
| US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| GB201809341D0 (en) * | 2018-06-07 | 2018-07-25 | Ucb Biopharma Sprl | Multi-domain proteins with increased native state colloidal stability |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69810603T2 (de) | 1997-04-11 | 2003-11-13 | California Inst Of Techn | Gerät und verfahren für automatischen protein-entwurf |
| EP1255209A3 (de) | 1997-04-11 | 2009-02-11 | California Institute Of Technology | Gerät und Verfahren für automatischen Protein-Entwurf |
| JP2002526508A (ja) | 1998-09-21 | 2002-08-20 | イシス・イノベイシヨン・リミテツド | フィブリル |
| GB9924484D0 (en) * | 1999-10-15 | 1999-12-15 | Isis Innovation | Altered polypeptide aggregation |
| EP1335937A2 (de) | 2000-11-24 | 2003-08-20 | Isis Innovation Limited | Gemischte fibrillen |
| GB0109438D0 (en) | 2001-04-17 | 2001-06-06 | Isis Innovation | Peptides |
| JP3802416B2 (ja) * | 2001-12-27 | 2006-07-26 | セレスター・レキシコ・サイエンシズ株式会社 | 相互作用部位予測装置、相互作用部位予測方法、プログラム、および、記録媒体 |
| DE602004025669D1 (de) | 2003-01-20 | 2010-04-08 | Cambridge Entpr Ltd | Rechnerisches verfahren und vorrichtung zur vorhersage der polypeptidaggregation oder lösbarkeit |
| GB0325817D0 (en) | 2003-11-05 | 2003-12-10 | Univ Cambridge Tech | Method and apparatus for assessing polypeptide aggregation |
-
2003
- 2003-11-05 GB GBGB0325817.5A patent/GB0325817D0/en not_active Ceased
-
2004
- 2004-10-01 ES ES04791642T patent/ES2376463T3/es active Active
- 2004-10-01 AT AT04791642T patent/ATE532072T1/de active
- 2004-10-01 DK DK04791642.4T patent/DK1680681T3/da active
- 2004-10-01 EP EP04791642A patent/EP1680681B1/de not_active Not-in-force
- 2004-10-01 EP EP10182317.7A patent/EP2261670B1/de not_active Not-in-force
- 2004-10-01 WO PCT/GB2004/050015 patent/WO2005045442A1/en active Application Filing
-
2006
- 2006-05-04 US US11/417,525 patent/US7698070B2/en not_active Expired - Fee Related
-
2010
- 2010-03-08 US US12/719,631 patent/US8155888B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7698070B2 (en) | 2010-04-13 |
| US20060271306A1 (en) | 2006-11-30 |
| EP2261670B1 (de) | 2014-08-20 |
| WO2005045442A1 (en) | 2005-05-19 |
| EP1680681B1 (de) | 2011-11-02 |
| DK1680681T3 (da) | 2012-02-27 |
| ES2376463T3 (es) | 2012-03-14 |
| EP2261670A2 (de) | 2010-12-15 |
| EP1680681A1 (de) | 2006-07-19 |
| GB0325817D0 (en) | 2003-12-10 |
| EP2261670A3 (de) | 2011-03-23 |
| US20100261882A1 (en) | 2010-10-14 |
| US8155888B2 (en) | 2012-04-10 |
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