DK168048B1 - Renset human interleukin-1, dets fremstilling og anvendelse i farmaceutiske praeparater - Google Patents

Renset human interleukin-1, dets fremstilling og anvendelse i farmaceutiske praeparater Download PDF

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Publication number
DK168048B1
DK168048B1 DK110485A DK110485A DK168048B1 DK 168048 B1 DK168048 B1 DK 168048B1 DK 110485 A DK110485 A DK 110485A DK 110485 A DK110485 A DK 110485A DK 168048 B1 DK168048 B1 DK 168048B1
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DK
Denmark
Prior art keywords
protein
amino acid
dna
column
leu
Prior art date
Application number
DK110485A
Other languages
Danish (da)
English (en)
Other versions
DK110485A (da
DK110485D0 (da
Inventor
Douglas P Cerretti
Paul J Conlon
David J Cosman
Kenneth H Grabstein
Thomas P Hopp
Shirley R Kronheim
Alf D Larsen
Carl J March
Virginia L Price
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK168048(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/676,533 external-priority patent/US5484887A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of DK110485D0 publication Critical patent/DK110485D0/da
Publication of DK110485A publication Critical patent/DK110485A/da
Application granted granted Critical
Publication of DK168048B1 publication Critical patent/DK168048B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DK110485A 1984-06-19 1985-03-11 Renset human interleukin-1, dets fremstilling og anvendelse i farmaceutiske praeparater DK168048B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US62220184A 1984-06-19 1984-06-19
US62220184 1984-06-19
US63500684A 1984-07-27 1984-07-27
US63500684 1984-07-27
US67455584A 1984-11-26 1984-11-26
US67455584 1984-11-26
US67653384 1984-11-30
US06/676,533 US5484887A (en) 1984-06-19 1984-11-30 Homogeneous interleukin 1
US68764684A 1984-12-31 1984-12-31
US68764684 1984-12-31

Publications (3)

Publication Number Publication Date
DK110485D0 DK110485D0 (da) 1985-03-11
DK110485A DK110485A (da) 1985-12-20
DK168048B1 true DK168048B1 (da) 1994-01-24

Family

ID=27542003

Family Applications (2)

Application Number Title Priority Date Filing Date
DK110485A DK168048B1 (da) 1984-06-19 1985-03-11 Renset human interleukin-1, dets fremstilling og anvendelse i farmaceutiske praeparater
DK037293A DK37293A (da) 1984-06-19 1993-03-30 Renset interleukin-1 og dna, der koder for interleukin-1, samt deres fremstilling, vektorer indeholdende saadant dna og deres fremstilling og anvendelse ved transformering af vaerter for muliggoerelse af ekspression af interleukin-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK037293A DK37293A (da) 1984-06-19 1993-03-30 Renset interleukin-1 og dna, der koder for interleukin-1, samt deres fremstilling, vektorer indeholdende saadant dna og deres fremstilling og anvendelse ved transformering af vaerter for muliggoerelse af ekspression af interleukin-1

Country Status (10)

Country Link
EP (2) EP0456332B1 (de)
JP (3) JP3217698B2 (de)
AT (2) ATE84547T1 (de)
AU (1) AU579142B2 (de)
CA (2) CA1341433C (de)
DE (2) DE3588224T2 (de)
DK (2) DK168048B1 (de)
IE (1) IE61353B1 (de)
MX (1) MX9203654A (de)
NZ (1) NZ211386A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
CA2469492C (en) * 2001-12-11 2012-10-16 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
DE3588224D1 (de) 2000-09-14
ATE195344T1 (de) 2000-08-15
IE850614L (en) 1986-09-08
NZ211386A (en) 1989-04-26
DK37293D0 (da) 1993-03-30
DK110485A (da) 1985-12-20
EP0456332B1 (de) 2000-08-09
JP2000060577A (ja) 2000-02-29
EP0456332A1 (de) 1991-11-13
JP3009381B2 (ja) 2000-02-14
JP3217698B2 (ja) 2001-10-09
DK37293A (da) 1993-03-30
ATE84547T1 (de) 1993-01-15
EP0165654A2 (de) 1985-12-27
JPH10279598A (ja) 1998-10-20
DE3586972T2 (de) 1993-07-08
IE61353B1 (en) 1994-11-02
CA1341433C (en) 2003-06-24
DE3586972D1 (de) 1993-02-25
DE3588224T2 (de) 2001-10-25
JPH09118697A (ja) 1997-05-06
AU3986385A (en) 1986-01-02
EP0165654B1 (de) 1993-01-13
MX9203654A (es) 1992-07-01
CA1340978C (en) 2000-05-02
AU579142B2 (en) 1988-11-17
EP0165654A3 (en) 1988-05-04
DK110485D0 (da) 1985-03-11

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Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed