DE3586972D1 - Gereinigtes interleukin-1. - Google Patents

Gereinigtes interleukin-1.

Info

Publication number
DE3586972D1
DE3586972D1 DE8585301752T DE3586972T DE3586972D1 DE 3586972 D1 DE3586972 D1 DE 3586972D1 DE 8585301752 T DE8585301752 T DE 8585301752T DE 3586972 T DE3586972 T DE 3586972T DE 3586972 D1 DE3586972 D1 DE 3586972D1
Authority
DE
Germany
Prior art keywords
new
amino acid
cloning vector
interleukin
daltons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585301752T
Other languages
English (en)
Other versions
DE3586972T2 (de
Inventor
Douglas P Cerretti
Iii Paul J Conlon
David J Cosman
Kenneth H Grabstein
Thomas P Hopp
Shirley R Kronheim
Alf D Larsen
Carl J March
Virginia L Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cistron Biotechnology Inc
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3586972(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/676,533 external-priority patent/US5484887A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DE3586972D1 publication Critical patent/DE3586972D1/de
Publication of DE3586972T2 publication Critical patent/DE3586972T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE8585301752T 1984-06-19 1985-03-13 Gereinigtes interleukin-1. Expired - Lifetime DE3586972T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62220184A 1984-06-19 1984-06-19
US63500684A 1984-07-27 1984-07-27
US67455584A 1984-11-26 1984-11-26
US06/676,533 US5484887A (en) 1984-06-19 1984-11-30 Homogeneous interleukin 1
US68764684A 1984-12-31 1984-12-31

Publications (2)

Publication Number Publication Date
DE3586972D1 true DE3586972D1 (de) 1993-02-25
DE3586972T2 DE3586972T2 (de) 1993-07-08

Family

ID=27542003

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585301752T Expired - Lifetime DE3586972T2 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.
DE3588224T Expired - Lifetime DE3588224T2 (de) 1984-06-19 1985-03-13 Gereinigtes Interleukin-1 und für Interleukin-1 kodierende DNS und deren Herstellung, solche DNS enthaltende Vektoren und deren Herstellung und Verwendung zum Transformieren von Wirten, die die Expression von Interleukin-1 zulassen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3588224T Expired - Lifetime DE3588224T2 (de) 1984-06-19 1985-03-13 Gereinigtes Interleukin-1 und für Interleukin-1 kodierende DNS und deren Herstellung, solche DNS enthaltende Vektoren und deren Herstellung und Verwendung zum Transformieren von Wirten, die die Expression von Interleukin-1 zulassen

Country Status (10)

Country Link
EP (2) EP0456332B1 (de)
JP (3) JP3217698B2 (de)
AT (2) ATE84547T1 (de)
AU (1) AU579142B2 (de)
CA (2) CA1341433C (de)
DE (2) DE3586972T2 (de)
DK (2) DK168048B1 (de)
IE (1) IE61353B1 (de)
MX (1) MX9203654A (de)
NZ (1) NZ211386A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3588241T2 (de) * 1984-05-18 2002-12-05 New England Medical Center Inc Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co Inc DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
DE60231845D1 (de) * 2001-12-11 2009-05-14 Univ New Jersey Med Diagnoseverfahren für proteinprofilierung
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
DE3588241T2 (de) * 1984-05-18 2002-12-05 New England Medical Center Inc Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
DE3586972T2 (de) 1993-07-08
AU579142B2 (en) 1988-11-17
EP0456332B1 (de) 2000-08-09
EP0165654A2 (de) 1985-12-27
ATE84547T1 (de) 1993-01-15
NZ211386A (en) 1989-04-26
CA1340978C (en) 2000-05-02
DE3588224D1 (de) 2000-09-14
EP0165654A3 (en) 1988-05-04
DK168048B1 (da) 1994-01-24
DK110485D0 (da) 1985-03-11
JPH09118697A (ja) 1997-05-06
IE850614L (en) 1986-09-08
AU3986385A (en) 1986-01-02
IE61353B1 (en) 1994-11-02
EP0456332A1 (de) 1991-11-13
EP0165654B1 (de) 1993-01-13
ATE195344T1 (de) 2000-08-15
JP2000060577A (ja) 2000-02-29
JP3217698B2 (ja) 2001-10-09
DK110485A (da) 1985-12-20
MX9203654A (es) 1992-07-01
DK37293D0 (da) 1993-03-30
CA1341433C (en) 2003-06-24
JPH10279598A (ja) 1998-10-20
JP3009381B2 (ja) 2000-02-14
DK37293A (da) 1993-03-30
DE3588224T2 (de) 2001-10-25

Similar Documents

Publication Publication Date Title
DE3586972D1 (de) Gereinigtes interleukin-1.
Allen et al. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon
Narita et al. The amino acid sequence of cardiotoxin from Formosan cobra (Naja naja atra) venom
KR890003802A (ko) 재조합 dna 기술에 의해 제조된 소의 췌장 트립신 억제제, 그 제조 방법, 발현 벡터 및 재조합 숙주 및 그의 제약적 용도
EP0538030B1 (de) Neue neutrophilaktivierende Faktoren
US5120535A (en) Oncostatin M and novel compositions having anti-neoplastic activity
Travis et al. The amino acid sequence of ferredoxin from the sulfate reducing bacterium, Desulfovibrio gigas
KR880009125A (ko) 재조합 숙주에 의해 제조되는 췌장분비 트립신 억제제 및 그의 변이체, 그의 방법, 표현벡터 및 재조합 숙주 및 그의 제약상 용도
Klippenstein et al. The primary structure of myohemerythrin
Schmelzer et al. Biochemical characterization of recombinant human nerve growth factor
KR890000665A (ko) 크링글 치환이 있는 돌연변이체 t-PA
Proost et al. Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines
ATE163651T1 (de) Neues menschliches, rekombinantes interferon gamma
Byrne et al. Human granulocyte-macrophage colony-stimulating factor purified from a Hodgkin's tumor cell line
Nagata et al. Purification and characterization of recombinant murine immune interferon
KR940005798A (ko) 지방세포화 억제 인자 유도체, 그의 제조방법 및 용도
US5358707A (en) Oxidized variants of GM-CSF
ES2127192T3 (es) Polipeptidos especificos del epididimo y su aplicacion.
Francis et al. Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen.
Lauren et al. Covalent dimerization of recombinant human interferon-γ
EP0147175A3 (de) Basische-Polypeptiden und Verfahren zu deren Herstellung
Aggarwal et al. [34] Human tumor necrosis factor
Linder et al. Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography
Suzue et al. Cooperarive participation of two peptides from β-casein in leukocyte chemotaxis
MARDER Carboxyl-terminal amino acid sequences of two variant forms of the y chain of human plasma fibrinogen

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: CISTRON BIOTECHNOLOGY,INC., PINE BROOK, N.J., US

8365 Fully valid after opposition proceedings