ATE195344T1 - Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen - Google Patents

Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen

Info

Publication number
ATE195344T1
ATE195344T1 AT91201769T AT91201769T ATE195344T1 AT E195344 T1 ATE195344 T1 AT E195344T1 AT 91201769 T AT91201769 T AT 91201769T AT 91201769 T AT91201769 T AT 91201769T AT E195344 T1 ATE195344 T1 AT E195344T1
Authority
AT
Austria
Prior art keywords
interleukin
new
production
dna
expression
Prior art date
Application number
AT91201769T
Other languages
English (en)
Inventor
Douglas P Cerretti
Iii Paul J Conlon
David J Cosman
Kenneth H Grabstein
Thomas P Hopp
Shirley R Kronheim
Alf D Larsen
Carl J March
Virgina L Price
Original Assignee
Cistron Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE195344(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/676,533 external-priority patent/US5484887A/en
Application filed by Cistron Biotechnology Inc filed Critical Cistron Biotechnology Inc
Application granted granted Critical
Publication of ATE195344T1 publication Critical patent/ATE195344T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT91201769T 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen ATE195344T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62220184A 1984-06-19 1984-06-19
US63500684A 1984-07-27 1984-07-27
US67455584A 1984-11-26 1984-11-26
US06/676,533 US5484887A (en) 1984-06-19 1984-11-30 Homogeneous interleukin 1
US68764684A 1984-12-31 1984-12-31

Publications (1)

Publication Number Publication Date
ATE195344T1 true ATE195344T1 (de) 2000-08-15

Family

ID=27542003

Family Applications (2)

Application Number Title Priority Date Filing Date
AT85301752T ATE84547T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.
AT91201769T ATE195344T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT85301752T ATE84547T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.

Country Status (10)

Country Link
EP (2) EP0456332B1 (de)
JP (3) JP3217698B2 (de)
AT (2) ATE84547T1 (de)
AU (1) AU579142B2 (de)
CA (2) CA1341433C (de)
DE (2) DE3588224T2 (de)
DK (2) DK168048B1 (de)
IE (1) IE61353B1 (de)
MX (1) MX9203654A (de)
NZ (1) NZ211386A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
CA2469492C (en) * 2001-12-11 2012-10-16 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
DE3588224D1 (de) 2000-09-14
IE850614L (en) 1986-09-08
NZ211386A (en) 1989-04-26
DK168048B1 (da) 1994-01-24
DK37293D0 (da) 1993-03-30
DK110485A (da) 1985-12-20
EP0456332B1 (de) 2000-08-09
JP2000060577A (ja) 2000-02-29
EP0456332A1 (de) 1991-11-13
JP3009381B2 (ja) 2000-02-14
JP3217698B2 (ja) 2001-10-09
DK37293A (da) 1993-03-30
ATE84547T1 (de) 1993-01-15
EP0165654A2 (de) 1985-12-27
JPH10279598A (ja) 1998-10-20
DE3586972T2 (de) 1993-07-08
IE61353B1 (en) 1994-11-02
CA1341433C (en) 2003-06-24
DE3586972D1 (de) 1993-02-25
DE3588224T2 (de) 2001-10-25
JPH09118697A (ja) 1997-05-06
AU3986385A (en) 1986-01-02
EP0165654B1 (de) 1993-01-13
MX9203654A (es) 1992-07-01
CA1340978C (en) 2000-05-02
AU579142B2 (en) 1988-11-17
EP0165654A3 (en) 1988-05-04
DK110485D0 (da) 1985-03-11

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