DK168030B1 - Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. - Google Patents

Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. Download PDF

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Publication number
DK168030B1
DK168030B1 DK342684A DK342684A DK168030B1 DK 168030 B1 DK168030 B1 DK 168030B1 DK 342684 A DK342684 A DK 342684A DK 342684 A DK342684 A DK 342684A DK 168030 B1 DK168030 B1 DK 168030B1
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DK
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Prior art keywords
atoms
proteins
aqueous
solution
formula
Prior art date
Application number
DK342684A
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Danish (da)
English (en)
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DK342684A (da
DK342684D0 (da
Inventor
Horst Thurow
Original Assignee
Hoechst Ag
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Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK342684D0 publication Critical patent/DK342684D0/da
Publication of DK342684A publication Critical patent/DK342684A/da
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Publication of DK168030B1 publication Critical patent/DK168030B1/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK342684A 1983-07-13 1984-07-12 Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. DK168030B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3325223 1983-07-13
DE19833325223 DE3325223A1 (de) 1983-07-13 1983-07-13 Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung

Publications (3)

Publication Number Publication Date
DK342684D0 DK342684D0 (da) 1984-07-12
DK342684A DK342684A (da) 1985-01-14
DK168030B1 true DK168030B1 (da) 1994-01-24

Family

ID=6203842

Family Applications (1)

Application Number Title Priority Date Filing Date
DK342684A DK168030B1 (da) 1983-07-13 1984-07-12 Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader.

Country Status (15)

Country Link
US (1) US4637834A (fi)
EP (1) EP0131864B1 (fi)
JP (1) JPS6038398A (fi)
KR (1) KR920002934B1 (fi)
AT (1) ATE56876T1 (fi)
AU (1) AU579106B2 (fi)
DE (2) DE3325223A1 (fi)
DK (1) DK168030B1 (fi)
ES (2) ES8600319A1 (fi)
FI (1) FI80276C (fi)
GR (1) GR81504B (fi)
IE (1) IE57694B1 (fi)
IL (1) IL72389A (fi)
PT (1) PT78892A (fi)
ZA (1) ZA845384B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4956274A (en) * 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
AU4278393A (en) * 1992-04-07 1993-11-08 Mallinckrodt Veterinary, Inc. Lyophilized somatotropin formulations
ATE359824T1 (de) † 1992-07-31 2007-05-15 Genentech Inc Wässrige formulierung enthaltend menschliches wachstumshormon
US6790439B1 (en) 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions
JPH11514334A (ja) * 1995-06-07 1999-12-07 チロン コーポレーション タンパク質の可溶化、精製、および再生の方法
MX9602398A (es) * 1995-06-23 1997-02-28 Kimberly Clark Co Material polimerico modificado teniendo humectabilidad mejorada.
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
TR200200034T2 (tr) * 1999-07-12 2002-05-21 Grandis Biotech Gmbh Büyüme hormonu formülasyonları.
CN1665540A (zh) * 2002-07-09 2005-09-07 桑多斯股份公司 含1,2－丙二醇的高浓度人生长激素液体制剂
US7851433B2 (en) * 2003-08-13 2010-12-14 Novartis Vaccines And Diagnostics, Inc. Method of purifying TFPI and TFPI analogs
CA2559918A1 (en) 2004-04-07 2005-11-10 Tudor Arvinte Liquid growth hormone formulation
EP1847830A1 (en) * 2006-04-20 2007-10-24 TF Instruments, Inc. Determining optimal concentrations of protective additives for biomolecules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439355A (en) * 1976-12-02 1984-03-27 Colgate-Palmolive Company Elastic detergent product of improved foaming power after use
DE2917535C2 (de) * 1979-04-30 1986-10-30 Hoechst Ag, 6230 Frankfurt Gegen Denaturierung beständige Insulinlösungen
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
WO1983000288A1 (en) * 1981-07-17 1983-02-03 Balschmidt, Per A stable aqueous, therapeutic insulin preparation and a process for preparing it

Also Published As

Publication number Publication date
EP0131864B1 (de) 1990-09-26
ES8609361A1 (es) 1986-09-01
ES535482A0 (es) 1986-09-01
ATE56876T1 (de) 1990-10-15
FI842798A (fi) 1985-01-14
IE841796L (en) 1985-01-13
DK342684A (da) 1985-01-14
DK342684D0 (da) 1984-07-12
IE57694B1 (en) 1993-03-10
KR850000971A (ko) 1985-03-14
GR81504B (fi) 1984-12-11
PT78892A (de) 1984-08-01
KR920002934B1 (ko) 1992-04-10
FI80276C (fi) 1990-05-10
ES534195A0 (es) 1985-10-01
JPS6038398A (ja) 1985-02-27
IL72389A (en) 1988-11-30
ES8600319A1 (es) 1985-10-01
AU3053784A (en) 1985-01-17
US4637834A (en) 1987-01-20
AU579106B2 (en) 1988-11-17
FI842798A0 (fi) 1984-07-11
EP0131864A2 (de) 1985-01-23
JPH0582397B2 (fi) 1993-11-18
ZA845384B (en) 1985-02-27
DE3325223A1 (de) 1985-01-24
DE3483287D1 (de) 1990-10-31
FI80276B (fi) 1990-01-31
EP0131864A3 (en) 1987-08-26
IL72389A0 (en) 1984-11-30

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B1 Patent granted (law 1993)
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