DK1671942T4 - Aerosolformulering omfattende levalbuterol L-tartratsalt - Google Patents
Aerosolformulering omfattende levalbuterol L-tartratsaltInfo
- Publication number
- DK1671942T4 DK1671942T4 DK06110646.4T DK06110646T DK1671942T4 DK 1671942 T4 DK1671942 T4 DK 1671942T4 DK 06110646 T DK06110646 T DK 06110646T DK 1671942 T4 DK1671942 T4 DK 1671942T4
- Authority
- DK
- Denmark
- Prior art keywords
- levalbuterol
- aerosol formulation
- tartrate salt
- tartare
- metered dose
- Prior art date
Links
- 229950008204 levosalbutamol Drugs 0.000 title abstract 2
- 239000000443 aerosol Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- -1 levalbuterol L-tartrate salt Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- NDAUXUAQIAJITI-LBPRGKRZSA-N (R)-salbutamol Chemical compound CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-LBPRGKRZSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 229940071648 metered dose inhaler Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/30—Materials not provided for elsewhere for aerosols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0484—Alcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0488—Surfactant, e.g. for the lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43219502P | 2002-12-10 | 2002-12-10 | |
| EP03786896A EP1572622B1 (en) | 2002-12-10 | 2003-12-08 | use of levalbuterol L-tartrate in the production of a metered dose inhaler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1671942T3 DK1671942T3 (da) | 2011-04-26 |
| DK1671942T4 true DK1671942T4 (da) | 2014-09-22 |
Family
ID=32507867
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06110646.4T DK1671942T4 (da) | 2002-12-10 | 2003-12-08 | Aerosolformulering omfattende levalbuterol L-tartratsalt |
| DK10176026.2T DK2292584T3 (en) | 2002-12-10 | 2003-12-08 | Pharmaceutical composition comprising levalbuterol L-hemitartrate salt as aerosol formulation |
| DK03786896T DK1572622T3 (da) | 2002-12-10 | 2003-12-08 | Anvendelse af levalbuterol-L-tartrat ved fremstilling af en doseringsinhalator |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10176026.2T DK2292584T3 (en) | 2002-12-10 | 2003-12-08 | Pharmaceutical composition comprising levalbuterol L-hemitartrate salt as aerosol formulation |
| DK03786896T DK1572622T3 (da) | 2002-12-10 | 2003-12-08 | Anvendelse af levalbuterol-L-tartrat ved fremstilling af en doseringsinhalator |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US7256310B2 (enExample) |
| EP (3) | EP1671942B2 (enExample) |
| JP (1) | JP4570960B2 (enExample) |
| KR (3) | KR101166955B1 (enExample) |
| AT (2) | ATE324364T1 (enExample) |
| AU (1) | AU2003295695B2 (enExample) |
| CA (1) | CA2507572C (enExample) |
| CY (2) | CY1106315T1 (enExample) |
| DE (2) | DE60304900T2 (enExample) |
| DK (3) | DK1671942T4 (enExample) |
| ES (3) | ES2626648T3 (enExample) |
| IL (2) | IL168739A (enExample) |
| MX (1) | MXPA05006087A (enExample) |
| NO (1) | NO331649B1 (enExample) |
| NZ (1) | NZ541168A (enExample) |
| PL (1) | PL212725B1 (enExample) |
| PT (3) | PT1572622E (enExample) |
| SI (2) | SI1671942T2 (enExample) |
| WO (1) | WO2004052835A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6466862B1 (en) * | 1999-04-19 | 2002-10-15 | Bruce DeKock | System for providing traffic information |
| JP2008512434A (ja) * | 2004-09-09 | 2008-04-24 | シプラ・リミテッド | ベータ擬似剤の異性体及び抗コリン作用剤を含む医薬組成物 |
| RU2440972C2 (ru) | 2004-12-17 | 2012-01-27 | Сипла Лимитед | Кристаллический сульфат левосальбутамола, способ его получения и фармацевтическая композиция, содержащая его |
| EP2311793A1 (en) | 2004-12-17 | 2011-04-20 | Cipla Ltd. | Crystalline levosalbutamol sulphate (Form II) |
| US8751589B2 (en) | 2011-04-13 | 2014-06-10 | Jingle Technologies Llc | Systems and methods for transmitting information, alerts, and/or comments to participants based on location information |
| EP3042892A1 (en) | 2015-01-09 | 2016-07-13 | Deva Holding Anonim Sirketi | Amorphisation of levosalbutamol tartrate |
| CN106727318A (zh) * | 2016-12-22 | 2017-05-31 | 山东京卫制药有限公司 | 一种气雾剂及其制备方法 |
| US20210290568A1 (en) * | 2020-03-19 | 2021-09-23 | Cai Gu Huang | Inhalable formulation of a solution containing levalbuterol tartrate |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828477D0 (en) † | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5345980A (en) | 1989-09-21 | 1994-09-13 | Glaxo Group Limited | Method and apparatus an aerosol container |
| US5362755A (en) | 1990-01-05 | 1994-11-08 | Sepracor, Inc. | Method for treating asthma using optically pure (R)-albuterol |
| US5255183A (en) * | 1990-05-29 | 1993-10-19 | Interactive Voice Data System Inc. | Telephone-based personnel tracking system |
| ATE226067T1 (de) * | 1991-06-10 | 2002-11-15 | Schering Corp | Fluorchlorkohlenwasserstofffreie aerosolformulierungen |
| NZ246421A (en) | 1991-12-18 | 1996-05-28 | Minnesota Mining & Mfg | Aerosol formulation containing a drug and a propellant and which is substantially free of surfactant |
| US5399765A (en) * | 1994-05-23 | 1995-03-21 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| US5545745A (en) * | 1994-05-23 | 1996-08-13 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| BR9604976A (pt) * | 1995-04-14 | 1998-06-09 | Glaxo Wellcome Inc | Inalador de dose medida sistema inalador de dose medida e uso do mesmo |
| US5603918A (en) | 1995-06-09 | 1997-02-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aerosol composition of a salt of ipratropium and a salt of albuterol |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| GB9806462D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Improved compositions for inhalation |
| ATE283033T1 (de) * | 1998-07-24 | 2004-12-15 | Jago Res Ag | Medizinische aerosolformulierungen |
| EP1102579B1 (de) * | 1998-08-04 | 2003-03-19 | Jago Research Ag | Medizinische aerosolformulierungen |
| DK1131059T3 (da) * | 1998-11-13 | 2003-06-30 | Jago Res Ag | Tørpulver til inhalation |
| CN1173929C (zh) | 1999-10-19 | 2004-11-03 | 中国科学院成都有机化学研究所 | 光学纯肾上腺素类β-激动剂的组合拆分制备法 |
| US6451289B2 (en) | 2000-03-24 | 2002-09-17 | Sepracor Inc. | Albuterol formulations |
| GB0030171D0 (en) | 2000-12-11 | 2001-01-24 | Cipla Ltd | Process for preparing isomers of salbutamol |
| DE50211045D1 (de) * | 2001-03-30 | 2007-11-22 | Jagotec Ag | Medizinische aerosolformulierungen |
| DE10120531A1 (de) * | 2001-04-26 | 2002-10-31 | Basf Ag | Neue Reaktivfarbstoffe und deren Verwendung zum Färben von Substraten, welche nucleophile Gruppen enthalten |
| CN1206205C (zh) * | 2001-04-26 | 2005-06-15 | 中国科学院成都有机化学研究所 | R－沙丁胺醇酒石酸盐的制备方法 |
-
2003
- 2003-12-08 PT PT03786896T patent/PT1572622E/pt unknown
- 2003-12-08 PT PT101760262T patent/PT2292584T/pt unknown
- 2003-12-08 DK DK06110646.4T patent/DK1671942T4/da active
- 2003-12-08 AU AU2003295695A patent/AU2003295695B2/en not_active Expired
- 2003-12-08 DK DK10176026.2T patent/DK2292584T3/en active
- 2003-12-08 ES ES10176026.2T patent/ES2626648T3/es not_active Expired - Lifetime
- 2003-12-08 EP EP06110646.4A patent/EP1671942B2/en not_active Expired - Lifetime
- 2003-12-08 PT PT06110646T patent/PT1671942E/pt unknown
- 2003-12-08 EP EP10176026.2A patent/EP2292584B1/en not_active Expired - Lifetime
- 2003-12-08 PL PL377336A patent/PL212725B1/pl unknown
- 2003-12-08 ES ES06110646.4T patent/ES2361172T5/es not_active Expired - Lifetime
- 2003-12-08 WO PCT/US2003/037079 patent/WO2004052835A1/en not_active Ceased
- 2003-12-08 DK DK03786896T patent/DK1572622T3/da active
- 2003-12-08 US US10/728,873 patent/US7256310B2/en not_active Expired - Lifetime
- 2003-12-08 DE DE60304900T patent/DE60304900T2/de not_active Expired - Lifetime
- 2003-12-08 CA CA2507572A patent/CA2507572C/en not_active Expired - Lifetime
- 2003-12-08 AT AT03786896T patent/ATE324364T1/de active
- 2003-12-08 MX MXPA05006087A patent/MXPA05006087A/es active IP Right Grant
- 2003-12-08 SI SI200331954T patent/SI1671942T2/sl unknown
- 2003-12-08 NZ NZ541168A patent/NZ541168A/en not_active IP Right Cessation
- 2003-12-08 DE DE60336089T patent/DE60336089D1/de not_active Expired - Lifetime
- 2003-12-08 ES ES03786896T patent/ES2263051T3/es not_active Expired - Lifetime
- 2003-12-08 AT AT06110646T patent/ATE498604T1/de active
- 2003-12-08 KR KR1020087028024A patent/KR101166955B1/ko not_active Expired - Fee Related
- 2003-12-08 JP JP2004559144A patent/JP4570960B2/ja not_active Expired - Fee Related
- 2003-12-08 KR KR1020057010435A patent/KR20050088307A/ko not_active Ceased
- 2003-12-08 EP EP03786896A patent/EP1572622B1/en not_active Expired - Lifetime
- 2003-12-08 SI SI200330331T patent/SI1572622T1/sl unknown
- 2003-12-08 KR KR1020107014278A patent/KR20100080865A/ko not_active Ceased
-
2005
- 2005-05-23 IL IL168739A patent/IL168739A/en active IP Right Grant
- 2005-07-08 NO NO20053339A patent/NO331649B1/no not_active IP Right Cessation
-
2006
- 2006-07-03 CY CY20061100912T patent/CY1106315T1/el unknown
-
2007
- 2007-08-08 US US11/891,048 patent/US20080119564A1/en not_active Abandoned
-
2010
- 2010-07-09 US US12/833,882 patent/US20100272654A1/en not_active Abandoned
-
2011
- 2011-03-11 CY CY20111100273T patent/CY1111330T1/el unknown
- 2011-04-14 IL IL212369A patent/IL212369A/en active IP Right Grant
-
2012
- 2012-10-02 US US13/633,801 patent/US20130028845A1/en not_active Abandoned
-
2013
- 2013-04-29 US US13/873,084 patent/US8765153B2/en not_active Expired - Lifetime
-
2014
- 2014-05-21 US US14/283,754 patent/US20150071969A1/en not_active Abandoned
-
2016
- 2016-01-22 US US15/003,883 patent/US20160368858A1/en not_active Abandoned
-
2017
- 2017-10-18 US US15/786,917 patent/US20180222845A1/en not_active Abandoned
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