DK1670458T3 - 1-Amino-2-oxy-substituerede tetrahydronaphthalenderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som antiphlogistika - Google Patents
1-Amino-2-oxy-substituerede tetrahydronaphthalenderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som antiphlogistikaInfo
- Publication number
- DK1670458T3 DK1670458T3 DK04790271T DK04790271T DK1670458T3 DK 1670458 T3 DK1670458 T3 DK 1670458T3 DK 04790271 T DK04790271 T DK 04790271T DK 04790271 T DK04790271 T DK 04790271T DK 1670458 T3 DK1670458 T3 DK 1670458T3
- Authority
- DK
- Denmark
- Prior art keywords
- tetrahydronaphthalane
- antiphlogistics
- oxy
- derivatives
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
- C07C211/58—Naphthylamines; N-substituted derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10347383A DE10347383A1 (de) | 2003-10-08 | 2003-10-08 | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
DE10347386A DE10347386B4 (de) | 2003-10-08 | 2003-10-08 | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
DE102004017662A DE102004017662B3 (de) | 2004-04-05 | 2004-04-05 | Mehrfach substituierte Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
PCT/EP2004/011370 WO2005034939A1 (de) | 2003-10-08 | 2004-10-06 | Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1670458T3 true DK1670458T3 (da) | 2007-04-23 |
Family
ID=34437487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04790271T DK1670458T3 (da) | 2003-10-08 | 2004-10-06 | 1-Amino-2-oxy-substituerede tetrahydronaphthalenderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som antiphlogistika |
Country Status (30)
Country | Link |
---|---|
US (1) | US7659297B2 (el) |
EP (1) | EP1670458B1 (el) |
JP (1) | JP4638438B2 (el) |
KR (1) | KR20070000395A (el) |
AR (1) | AR046062A1 (el) |
AT (1) | ATE348609T1 (el) |
AU (1) | AU2004280088B2 (el) |
BR (1) | BRPI0415209A (el) |
CA (1) | CA2539587A1 (el) |
CR (1) | CR8357A (el) |
CY (1) | CY1107596T1 (el) |
DE (1) | DE502004002403D1 (el) |
DK (1) | DK1670458T3 (el) |
EA (1) | EA010186B1 (el) |
EC (1) | ECSP066539A (el) |
ES (1) | ES2279454T3 (el) |
HK (1) | HK1097734A1 (el) |
HN (1) | HN2004000446A (el) |
IL (1) | IL174405A (el) |
ME (1) | MEP15908A (el) |
MY (1) | MY141853A (el) |
NO (1) | NO20062020L (el) |
NZ (1) | NZ546473A (el) |
PE (1) | PE20060604A1 (el) |
PL (1) | PL1670458T3 (el) |
PT (1) | PT1670458E (el) |
RS (1) | RS20060250A (el) |
SI (1) | SI1670458T1 (el) |
TW (1) | TWI306455B (el) |
WO (1) | WO2005034939A1 (el) |
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US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
AU2004280088B2 (en) | 2003-10-08 | 2010-05-27 | Bayer Schering Pharma Aktiengesellschaft | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics |
US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060084652A1 (en) * | 2004-09-09 | 2006-04-20 | Stefan Baeurle | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
DE102004044680B3 (de) * | 2004-09-09 | 2006-06-08 | Schering Ag | Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
US20060167025A1 (en) * | 2004-12-22 | 2006-07-27 | Markus Berger | Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs |
DE102004063227A1 (de) * | 2004-12-22 | 2006-07-06 | Schering Ag | Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20060229305A1 (en) * | 2005-03-22 | 2006-10-12 | Markus Berger | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060247292A1 (en) * | 2005-03-22 | 2006-11-02 | Hartmut Rehwinkel | Benzocycloheptene derivatives, process for their production and their use as anti-inflammatory agents |
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DE102005017286B3 (de) * | 2005-04-14 | 2006-12-28 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
EP1834948A1 (de) * | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
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AU2010280323A1 (en) | 2009-07-31 | 2012-03-08 | Cadila Healthcare Limited | Novel compounds as modulators of glucocorticoid receptors |
WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
GB201002243D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
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AU2004280088B2 (en) | 2003-10-08 | 2010-05-27 | Bayer Schering Pharma Aktiengesellschaft | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics |
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US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20050222154A1 (en) * | 2004-04-05 | 2005-10-06 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
DE102004044680B3 (de) | 2004-09-09 | 2006-06-08 | Schering Ag | Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
US20060084652A1 (en) | 2004-09-09 | 2006-04-20 | Stefan Baeurle | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060165615A1 (en) * | 2004-11-23 | 2006-07-27 | Shende Rajesh V | Non-oxidative tooth whiteners for dentifrice application |
DE102004063227A1 (de) | 2004-12-22 | 2006-07-06 | Schering Ag | Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20060167025A1 (en) | 2004-12-22 | 2006-07-27 | Markus Berger | Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs |
US20060229305A1 (en) | 2005-03-22 | 2006-10-12 | Markus Berger | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060247292A1 (en) | 2005-03-22 | 2006-11-02 | Hartmut Rehwinkel | Benzocycloheptene derivatives, process for their production and their use as anti-inflammatory agents |
DE102005014089A1 (de) | 2005-03-22 | 2006-09-28 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20070129359A1 (en) | 2005-04-14 | 2007-06-07 | Christoph Huwe | Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents |
DE102005017286B3 (de) | 2005-04-14 | 2006-12-28 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20070015761A1 (en) | 2005-04-14 | 2007-01-18 | Anne Mengel | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
ES2414479T3 (es) | 2005-04-14 | 2013-07-19 | Glaxo Group Limited | Indazoles como ligandos del receptor de glucocorticoides |
US20070015750A1 (en) | 2005-04-14 | 2007-01-18 | Stefan Baeurle | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
BRPI0619518A2 (pt) | 2005-12-09 | 2011-10-11 | Hoffmann La Roche | moduladores do receptor de glicocorticoide, composição farmacêutica que os compreende e usos dos mesmos |
EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
-
2004
- 2004-10-06 AU AU2004280088A patent/AU2004280088B2/en not_active Ceased
- 2004-10-06 CA CA002539587A patent/CA2539587A1/en not_active Abandoned
- 2004-10-06 ME MEP-159/08A patent/MEP15908A/xx unknown
- 2004-10-06 NZ NZ546473A patent/NZ546473A/en not_active IP Right Cessation
- 2004-10-06 SI SI200430231T patent/SI1670458T1/sl unknown
- 2004-10-06 ES ES04790271T patent/ES2279454T3/es active Active
- 2004-10-06 PT PT04790271T patent/PT1670458E/pt unknown
- 2004-10-06 DE DE502004002403T patent/DE502004002403D1/de active Active
- 2004-10-06 RS YUP-2006/0250A patent/RS20060250A/sr unknown
- 2004-10-06 DK DK04790271T patent/DK1670458T3/da active
- 2004-10-06 EA EA200600621A patent/EA010186B1/ru not_active IP Right Cessation
- 2004-10-06 BR BRPI0415209-3A patent/BRPI0415209A/pt not_active IP Right Cessation
- 2004-10-06 WO PCT/EP2004/011370 patent/WO2005034939A1/de active IP Right Grant
- 2004-10-06 JP JP2006530142A patent/JP4638438B2/ja not_active Expired - Fee Related
- 2004-10-06 EP EP04790271A patent/EP1670458B1/de not_active Not-in-force
- 2004-10-06 PL PL04790271T patent/PL1670458T3/pl unknown
- 2004-10-06 KR KR1020067006768A patent/KR20070000395A/ko active IP Right Grant
- 2004-10-06 AT AT04790271T patent/ATE348609T1/de active
- 2004-10-08 TW TW093130577A patent/TWI306455B/zh not_active IP Right Cessation
- 2004-10-08 MY MYPI20044145A patent/MY141853A/en unknown
- 2004-10-08 AR ARP040103651A patent/AR046062A1/es not_active Application Discontinuation
- 2004-10-08 US US10/960,754 patent/US7659297B2/en not_active Expired - Fee Related
- 2004-11-03 HN HN2004000446A patent/HN2004000446A/es unknown
- 2004-11-11 PE PE2004001100A patent/PE20060604A1/es not_active Application Discontinuation
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2006
- 2006-03-20 IL IL174405A patent/IL174405A/en not_active IP Right Cessation
- 2006-04-24 CR CR8357A patent/CR8357A/es not_active Application Discontinuation
- 2006-05-02 EC EC2006006539A patent/ECSP066539A/es unknown
- 2006-05-05 NO NO20062020A patent/NO20062020L/no not_active Application Discontinuation
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2007
- 2007-02-15 HK HK07101854.6A patent/HK1097734A1/xx not_active IP Right Cessation
- 2007-03-20 CY CY20071100384T patent/CY1107596T1/el unknown
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