DK167006B1 - 5-hydroxy-1,4-naftoquinoner, fremgangsmaade til fremstilling deraf samt antifibrotisk praeparat indeholdende en saadan forbindelse - Google Patents
5-hydroxy-1,4-naftoquinoner, fremgangsmaade til fremstilling deraf samt antifibrotisk praeparat indeholdende en saadan forbindelse Download PDFInfo
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- DK167006B1 DK167006B1 DK551083A DK551083A DK167006B1 DK 167006 B1 DK167006 B1 DK 167006B1 DK 551083 A DK551083 A DK 551083A DK 551083 A DK551083 A DK 551083A DK 167006 B1 DK167006 B1 DK 167006B1
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- DK
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- Prior art keywords
- fractions
- liters
- compound
- methanol
- ethyl acetate
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- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
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- 229910052751 metal Inorganic materials 0.000 description 1
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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- 206010028537 myelofibrosis Diseases 0.000 description 1
- 201000009925 nephrosclerosis Diseases 0.000 description 1
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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- 239000003549 soybean oil Substances 0.000 description 1
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- 150000003462 sulfoxides Chemical class 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 229940035893 uracil Drugs 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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- 239000003643 water by type Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58142347A JPS6034185A (ja) | 1983-08-02 | 1983-08-02 | 生理活性物質ｐ−２３９２４，その製造法および製剤 |
| JP14234783 | 1983-08-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK551083D0 DK551083D0 (da) | 1983-12-01 |
| DK551083A DK551083A (da) | 1985-02-03 |
| DK167006B1 true DK167006B1 (da) | 1993-08-16 |
Family
ID=15313248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK551083A DK167006B1 (da) | 1983-08-02 | 1983-12-01 | 5-hydroxy-1,4-naftoquinoner, fremgangsmaade til fremstilling deraf samt antifibrotisk praeparat indeholdende en saadan forbindelse |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS6034185A (enrdf_load_stackoverflow) |
| DK (1) | DK167006B1 (enrdf_load_stackoverflow) |
-
1983
- 1983-08-02 JP JP58142347A patent/JPS6034185A/ja active Granted
- 1983-12-01 DK DK551083A patent/DK167006B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6034185A (ja) | 1985-02-21 |
| DK551083D0 (da) | 1983-12-01 |
| JPH0365341B2 (enrdf_load_stackoverflow) | 1991-10-11 |
| DK551083A (da) | 1985-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |