DK166390C - Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner - Google Patents

Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner

Info

Publication number
DK166390C
DK166390C DK196185A DK196185A DK166390C DK 166390 C DK166390 C DK 166390C DK 196185 A DK196185 A DK 196185A DK 196185 A DK196185 A DK 196185A DK 166390 C DK166390 C DK 166390C
Authority
DK
Denmark
Prior art keywords
adduct
preparing
halo
lincomycines
desoxy
Prior art date
Application number
DK196185A
Other languages
Danish (da)
English (en)
Other versions
DK166390B (da
DK196185D0 (da
DK196185A (da
Inventor
Douglas Alan Livingston
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK196185D0 publication Critical patent/DK196185D0/da
Publication of DK196185A publication Critical patent/DK196185A/da
Publication of DK166390B publication Critical patent/DK166390B/da
Application granted granted Critical
Publication of DK166390C publication Critical patent/DK166390C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK196185A 1984-05-15 1985-05-01 Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner DK166390C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/610,364 US4568741A (en) 1984-05-15 1984-05-15 Synthesis of 7-halo-7-deoxylincomycins
US61036484 1984-05-15

Publications (4)

Publication Number Publication Date
DK196185D0 DK196185D0 (da) 1985-05-01
DK196185A DK196185A (da) 1985-11-16
DK166390B DK166390B (da) 1993-05-10
DK166390C true DK166390C (da) 1993-09-27

Family

ID=24444721

Family Applications (1)

Application Number Title Priority Date Filing Date
DK196185A DK166390C (da) 1984-05-15 1985-05-01 Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner

Country Status (18)

Country Link
US (1) US4568741A (cs)
EP (1) EP0161794B1 (cs)
JP (1) JPS60260591A (cs)
KR (1) KR910002224B1 (cs)
AT (1) ATE54150T1 (cs)
AU (1) AU574453B2 (cs)
CA (1) CA1229592A (cs)
DE (1) DE3578425D1 (cs)
DK (1) DK166390C (cs)
ES (1) ES8606877A1 (cs)
FI (1) FI78108C (cs)
GR (1) GR851150B (cs)
HK (1) HK59293A (cs)
HU (1) HU196820B (cs)
IL (2) IL74971A (cs)
MX (1) MX163480B (cs)
PT (1) PT80463B (cs)
ZA (1) ZA852592B (cs)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
TW282399B (cs) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
DE4039750A1 (de) * 1990-12-13 1992-06-17 Basf Ag Verfahren zur entfernung von phosgen aus abgasen
JP3202960B2 (ja) 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
WO2003020736A1 (en) * 2001-08-28 2003-03-13 Pharmacia Corporation Crystaline clindamycin free base
ZA200501012B (en) * 2002-08-15 2006-10-25 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US7141237B2 (en) 2003-01-24 2006-11-28 Connetics Australia Pty Ltd. Pharmaceutical foam
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
CA2533178C (en) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009368A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258944B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004264939A1 (en) 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
EP1653924A4 (en) 2003-08-12 2009-09-09 Middlebrook Pharmaceuticals In ANTIBIOTICS, USE AND FORMULATION ASSOCIATED
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
WO2005027877A1 (en) * 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2550983C (en) * 2003-12-24 2013-09-17 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP2008505124A (ja) * 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
ES2582654T3 (es) 2006-03-31 2016-09-14 Stiefel Research Australia Pty Ltd Gel en suspensión espumable
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3475407A (en) * 1967-12-22 1969-10-28 Upjohn Co Process for preparing 7(r)- and 7(s)-halolincomycins
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
CA1138443A (en) * 1979-03-09 1982-12-28 Tate & Lyle Patent Holdings Limited Process for the preparation of chloro-deoxysugars
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Also Published As

Publication number Publication date
AU4095085A (en) 1985-11-21
ZA852592B (en) 1985-11-27
FI78108C (fi) 1989-06-12
FI78108B (fi) 1989-02-28
MX163480B (es) 1992-05-19
GR851150B (cs) 1985-11-25
JPS60260591A (ja) 1985-12-23
EP0161794B1 (en) 1990-06-27
HK59293A (en) 1993-06-25
IL75175A0 (en) 1985-09-29
KR850008349A (ko) 1985-12-16
CA1229592A (en) 1987-11-24
EP0161794A3 (en) 1987-07-29
PT80463A (en) 1985-06-01
ATE54150T1 (de) 1990-07-15
FI851941A0 (fi) 1985-05-15
EP0161794A2 (en) 1985-11-21
DK166390B (da) 1993-05-10
US4568741A (en) 1986-02-04
IL74971A0 (en) 1985-08-30
DK196185D0 (da) 1985-05-01
DE3578425D1 (de) 1990-08-02
JPH0533711B2 (cs) 1993-05-20
DK196185A (da) 1985-11-16
ES542940A0 (es) 1986-05-16
KR910002224B1 (ko) 1991-04-08
FI851941L (fi) 1985-11-16
ES8606877A1 (es) 1986-05-16
HUT40805A (en) 1987-02-27
IL74971A (en) 1991-07-18
AU574453B2 (en) 1988-07-07
HU196820B (en) 1989-01-30
PT80463B (pt) 1987-08-19

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