DK1646387T3 - Anvendelse af indazol-derivater til behandling af neuropatiske smerter - Google Patents

Anvendelse af indazol-derivater til behandling af neuropatiske smerter

Info

Publication number
DK1646387T3
DK1646387T3 DK04763164T DK04763164T DK1646387T3 DK 1646387 T3 DK1646387 T3 DK 1646387T3 DK 04763164 T DK04763164 T DK 04763164T DK 04763164 T DK04763164 T DK 04763164T DK 1646387 T3 DK1646387 T3 DK 1646387T3
Authority
DK
Denmark
Prior art keywords
treatment
neuropathic pain
indazole derivatives
indazole
derivatives
Prior art date
Application number
DK04763164T
Other languages
English (en)
Inventor
Angelo Guglielmotti
Lorenzo Polenzani
Alessandra Alisi
Nicola Cazzolla
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Application granted granted Critical
Publication of DK1646387T3 publication Critical patent/DK1646387T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK04763164T 2003-07-18 2004-07-08 Anvendelse af indazol-derivater til behandling af neuropatiske smerter DK1646387T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001468A ITMI20031468A1 (it) 2003-07-18 2003-07-18 Farmaco ativo nel dolore neuropatico
PCT/EP2004/007635 WO2005013989A1 (en) 2003-07-18 2004-07-08 Use of indazole derivatives for the treatment of neuropathic pain

Publications (1)

Publication Number Publication Date
DK1646387T3 true DK1646387T3 (da) 2007-03-19

Family

ID=34131194

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04763164T DK1646387T3 (da) 2003-07-18 2004-07-08 Anvendelse af indazol-derivater til behandling af neuropatiske smerter

Country Status (22)

Country Link
US (1) US7638534B2 (da)
EP (1) EP1646387B1 (da)
JP (1) JP4881729B2 (da)
KR (1) KR101073993B1 (da)
CN (1) CN100427089C (da)
AR (1) AR045994A1 (da)
AT (1) ATE345134T1 (da)
AU (1) AU2004262878B2 (da)
CA (1) CA2526052C (da)
DE (1) DE602004003251T2 (da)
DK (1) DK1646387T3 (da)
EA (1) EA008144B1 (da)
ES (1) ES2275232T3 (da)
GE (1) GEP20084343B (da)
HK (1) HK1087026A1 (da)
IL (1) IL172101A (da)
IT (1) ITMI20031468A1 (da)
MX (1) MXPA06000651A (da)
PL (1) PL1646387T3 (da)
PT (1) PT1646387E (da)
UA (1) UA81051C2 (da)
WO (1) WO2005013989A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20062230A1 (it) 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
AU2009276082B2 (en) 2008-07-29 2014-01-23 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
JP3294611B2 (ja) * 1991-09-12 2002-06-24 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター・アンタゴニスト
MA22647A1 (fr) * 1991-09-14 1993-04-01 Smithkline Beecham Plc Procede de preparation d'un ester ou d'un amide d'un nouveau produit .
GB9120628D0 (en) 1991-09-27 1991-11-06 Fujisawa Pharmaceutical Co Pyrrolobenzoxazine derivatives and process for preparation thereof
ES2132223T3 (es) 1992-03-12 1999-08-16 Smithkline Beecham Plc Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10132746A1 (de) * 2001-07-05 2003-02-06 Gruenenthal Gmbh Substituierte 1-Phenethylpiperidinverbindungen
US6624162B2 (en) * 2001-10-22 2003-09-23 Pfizer Inc. Imidazopyridine compounds as 5-HT4 receptor modulators
US20060135516A1 (en) * 2002-08-10 2006-06-22 Astex Technology, Ltd. 3-(Carbonyl) 1h-indazole compounds as cyclin dependent kinases (cdk) inhibitors
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.

Also Published As

Publication number Publication date
GEP20084343B (en) 2008-03-25
PL1646387T3 (pl) 2007-03-30
KR101073993B1 (ko) 2011-10-17
JP2009513544A (ja) 2009-04-02
UA81051C2 (en) 2007-11-26
DE602004003251T2 (de) 2007-05-10
HK1087026A1 (en) 2006-10-06
MXPA06000651A (es) 2006-03-30
IL172101A (en) 2011-08-31
CA2526052C (en) 2011-08-30
WO2005013989A1 (en) 2005-02-17
DE602004003251D1 (de) 2006-12-28
CA2526052A1 (en) 2005-02-17
EP1646387A1 (en) 2006-04-19
AR045994A1 (es) 2005-11-23
PT1646387E (pt) 2007-01-31
ATE345134T1 (de) 2006-12-15
US20060183775A1 (en) 2006-08-17
EA200600271A1 (ru) 2006-06-30
ES2275232T3 (es) 2007-06-01
CN1809356A (zh) 2006-07-26
AU2004262878B2 (en) 2009-12-17
AU2004262878A1 (en) 2005-02-17
US7638534B2 (en) 2009-12-29
EA008144B1 (ru) 2007-04-27
JP4881729B2 (ja) 2012-02-22
EP1646387B1 (en) 2006-11-15
IL172101A0 (en) 2009-02-11
CN100427089C (zh) 2008-10-22
ITMI20031468A1 (it) 2005-01-19
KR20060033006A (ko) 2006-04-18

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