DK161143C - Fremgangsmaade til fremstilling af beta-((2-methylpropoxy)-methyl)-n-phenyl-n-(phenylmethyl)-1-pyrrolidinethanamin-hydrochlorid-hydrat - Google Patents

Fremgangsmaade til fremstilling af beta-((2-methylpropoxy)-methyl)-n-phenyl-n-(phenylmethyl)-1-pyrrolidinethanamin-hydrochlorid-hydrat

Info

Publication number
DK161143C
DK161143C DK391983A DK391983A DK161143C DK 161143 C DK161143 C DK 161143C DK 391983 A DK391983 A DK 391983A DK 391983 A DK391983 A DK 391983A DK 161143 C DK161143 C DK 161143C
Authority
DK
Denmark
Prior art keywords
pyrrolidinethanamine
methylpropoxy
phenylmethyl
phenyl
methyl
Prior art date
Application number
DK391983A
Other languages
Danish (da)
English (en)
Other versions
DK391983A (da
DK161143B (da
DK391983D0 (da
Inventor
Frank J Stiefel
Original Assignee
Carter Wallace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace filed Critical Carter Wallace
Publication of DK391983A publication Critical patent/DK391983A/da
Publication of DK391983D0 publication Critical patent/DK391983D0/da
Publication of DK161143B publication Critical patent/DK161143B/da
Application granted granted Critical
Publication of DK161143C publication Critical patent/DK161143C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Thermally Insulated Containers For Foods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK391983A 1981-12-28 1983-08-26 Fremgangsmaade til fremstilling af beta-((2-methylpropoxy)-methyl)-n-phenyl-n-(phenylmethyl)-1-pyrrolidinethanamin-hydrochlorid-hydrat DK161143C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33453581A 1981-12-28 1981-12-28
US33453581 1981-12-28
PCT/US1982/001754 WO1983002274A1 (en) 1981-12-28 1982-12-10 Synthesis of 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolidino hydrochloride
US8201754 1982-12-10

Publications (4)

Publication Number Publication Date
DK391983A DK391983A (da) 1983-08-26
DK391983D0 DK391983D0 (da) 1983-08-26
DK161143B DK161143B (da) 1991-06-03
DK161143C true DK161143C (da) 1991-11-18

Family

ID=23307674

Family Applications (1)

Application Number Title Priority Date Filing Date
DK391983A DK161143C (da) 1981-12-28 1983-08-26 Fremgangsmaade til fremstilling af beta-((2-methylpropoxy)-methyl)-n-phenyl-n-(phenylmethyl)-1-pyrrolidinethanamin-hydrochlorid-hydrat

Country Status (18)

Country Link
US (1) US4620015A (it)
EP (1) EP0096720B1 (it)
JP (1) JPS58502209A (it)
AT (1) ATE32715T1 (it)
AU (1) AU559555B2 (it)
BR (1) BR8208033A (it)
CA (1) CA1192907A (it)
DE (1) DE3278160D1 (it)
DK (1) DK161143C (it)
ES (1) ES8402257A1 (it)
FI (1) FI69304C (it)
IE (1) IE54312B1 (it)
IL (1) IL67533A (it)
IT (1) IT1157249B (it)
NO (1) NO158059C (it)
NZ (1) NZ202857A (it)
PT (1) PT76027B (it)
WO (1) WO1983002274A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
DE3468684D1 (de) * 1983-11-11 1988-02-18 Akzo Nv Ether of n-propanolamine derivative
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4888335A (en) * 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2568778A (en) * 1948-05-28 1951-09-25 Sterling Drug Inc Tertiary-aminoalkyl-alpha-arylalpha-(4-quinolyl) acetates and amides and their preparation
FR6571M (it) * 1967-08-03 1968-12-23
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application
CA1085841A (en) * 1976-05-19 1980-09-16 Jean-Marie Ferland Aryloxy proplamines, their preparation and use thereof
FR2376123A1 (fr) * 1977-01-04 1978-07-28 Esteve Intercional Sa Prod Nouveaux derives de 4-tert.butyl-3'-chlorodiphenylamine a activite anti-histaminique, et leur procede de preparation
JPS5429493A (en) * 1977-08-10 1979-03-05 Hitachi Ltd Slat type free flow conveyor

Also Published As

Publication number Publication date
FI833016A (fi) 1983-08-23
EP0096720A1 (en) 1983-12-28
IE54312B1 (en) 1989-08-16
IT1157249B (it) 1987-02-11
IE823025L (en) 1983-06-28
DE3278160D1 (en) 1988-04-07
BR8208033A (pt) 1983-11-22
NO158059C (no) 1988-07-06
IT8249760A0 (it) 1982-12-28
EP0096720A4 (en) 1984-05-29
ES518593A0 (es) 1984-02-01
FI69304B (fi) 1985-09-30
PT76027B (en) 1985-11-18
PT76027A (en) 1983-01-01
NZ202857A (en) 1986-04-11
JPS58502209A (ja) 1983-12-22
ATE32715T1 (de) 1988-03-15
FI833016A0 (fi) 1983-08-23
NO158059B (no) 1988-03-28
DK391983A (da) 1983-08-26
DK161143B (da) 1991-06-03
US4620015A (en) 1986-10-28
NO833071L (no) 1983-08-26
DK391983D0 (da) 1983-08-26
WO1983002274A1 (en) 1983-07-07
AU559555B2 (en) 1987-03-12
FI69304C (fi) 1986-01-10
CA1192907A (en) 1985-09-03
IL67533A (en) 1986-03-31
EP0096720B1 (en) 1988-03-02
ES8402257A1 (es) 1984-02-01

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Legal Events

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PBP Patent lapsed