DK160275C - Analogifremgangsmaade til fremstilling af 2-(2-(2,3-dihydrobenzofuranyl))-2-imidazolinderivater - Google Patents

Analogifremgangsmaade til fremstilling af 2-(2-(2,3-dihydrobenzofuranyl))-2-imidazolinderivater

Info

Publication number
DK160275C
DK160275C DK335682A DK335682A DK160275C DK 160275 C DK160275 C DK 160275C DK 335682 A DK335682 A DK 335682A DK 335682 A DK335682 A DK 335682A DK 160275 C DK160275 C DK 160275C
Authority
DK
Denmark
Prior art keywords
preparation
imidazoline derivatives
dihydrobenzofuranyl
hydrogen
analogy procedure
Prior art date
Application number
DK335682A
Other languages
Danish (da)
English (en)
Other versions
DK335682A (da
DK160275B (da
Inventor
Christopher Bourne Chapleo
Peter Leslie Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of DK335682A publication Critical patent/DK335682A/da
Publication of DK160275B publication Critical patent/DK160275B/da
Application granted granted Critical
Publication of DK160275C publication Critical patent/DK160275C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
DK335682A 1981-07-28 1982-07-27 Analogifremgangsmaade til fremstilling af 2-(2-(2,3-dihydrobenzofuranyl))-2-imidazolinderivater DK160275C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8123271 1981-07-28
GB8123271 1981-07-28

Publications (3)

Publication Number Publication Date
DK335682A DK335682A (da) 1983-01-29
DK160275B DK160275B (da) 1991-02-18
DK160275C true DK160275C (da) 1991-07-22

Family

ID=10523561

Family Applications (1)

Application Number Title Priority Date Filing Date
DK335682A DK160275C (da) 1981-07-28 1982-07-27 Analogifremgangsmaade til fremstilling af 2-(2-(2,3-dihydrobenzofuranyl))-2-imidazolinderivater

Country Status (24)

Country Link
US (1) US4411908A (es)
EP (1) EP0071368B1 (es)
JP (1) JPS5826884A (es)
AT (1) ATE12769T1 (es)
AU (1) AU549166B2 (es)
CA (1) CA1171864A (es)
CS (1) CS229938B2 (es)
DD (1) DD211349A5 (es)
DE (1) DE3263123D1 (es)
DK (1) DK160275C (es)
ES (1) ES8307796A1 (es)
FI (1) FI67545C (es)
GR (1) GR76210B (es)
HU (1) HU190023B (es)
IE (1) IE53389B1 (es)
IL (1) IL66353A (es)
NO (1) NO157215C (es)
NZ (1) NZ201219A (es)
PH (1) PH18878A (es)
PL (1) PL139439B1 (es)
PT (1) PT75329B (es)
SU (1) SU1204134A3 (es)
ZA (1) ZA825164B (es)
ZW (1) ZW13782A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
DE3465993D1 (en) * 1983-08-11 1987-10-15 Synthelabo Indole derivatives, their preparation and their therapeutical application
EP0139584B1 (fr) * 1983-10-17 1988-05-18 Synthelabo Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
KR910005851B1 (ko) * 1983-12-12 1991-08-05 신 떼라보 피롤로[3,2,1-hi]인돌유도체 및 약학적으로 허용되는 그의 산부가염을 제조하는 방법
FR2621486B1 (fr) * 1987-10-07 1990-01-26 Synthelabo Utilisation de derives de pyrrolo(3,2,1-hi)indole pour obtenir un medicament destine au traitement du diabete
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
CA1260947A (en) * 1984-12-29 1989-09-26 Yoshitaka Ohishi Benzofuran derivative, process for preparing the same and pharmaceutical composition containing the same
US4895867A (en) * 1986-06-26 1990-01-23 Norwich Eaton Pharmaceuticals, Inc. 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB9020128D0 (en) * 1990-09-14 1990-10-24 Reckitt & Colmann Prod Ltd Imidazoline derivatives
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
FR2706303B1 (fr) * 1993-06-18 1995-09-08 Pf Medicament Utilisation de l'Efaroxan et de ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson.
FR2707166B1 (fr) * 1993-07-09 1995-09-29 Pf Medicament Utilisation de l'efaroxan et de ses dérivés pour la fabrication de médicaments destinés au traitement de maladies neurodégénératives et leur progression .
ZA9811672B (en) * 1997-12-19 2000-06-19 Lilly Co Eli Hypoglycemic imidazoline compounds.
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
AU5319700A (en) * 1999-06-02 2000-12-18 S. Mbua Ngale Efange Nicotine receptor ligands
SE9902267D0 (sv) * 1999-06-16 1999-06-16 Astra Ab New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2168216A1 (en) * 1972-01-21 1973-08-31 Labaz Substd imidazolines - with vasoconstrictor activity
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.

Also Published As

Publication number Publication date
AU8643882A (en) 1983-06-02
HU190023B (en) 1986-08-28
IL66353A (en) 1985-08-30
NZ201219A (en) 1984-10-19
DK335682A (da) 1983-01-29
PH18878A (en) 1985-10-22
JPS5826884A (ja) 1983-02-17
IL66353A0 (en) 1982-11-30
ZW13782A1 (en) 1982-10-06
CA1171864A (en) 1984-07-31
ES514359A0 (es) 1983-08-01
DD211349A5 (de) 1984-07-11
IE53389B1 (en) 1988-10-26
NO822568L (no) 1983-01-31
PT75329B (en) 1984-07-31
ZA825164B (en) 1983-05-25
JPH0233038B2 (es) 1990-07-25
US4411908A (en) 1983-10-25
ES8307796A1 (es) 1983-08-01
FI67545C (fi) 1985-04-10
FI822551A0 (fi) 1982-07-20
EP0071368B1 (en) 1985-04-17
CS229938B2 (en) 1984-07-16
AU549166B2 (en) 1986-01-16
IE821789L (en) 1983-01-28
DE3263123D1 (de) 1985-05-23
PL237655A1 (en) 1983-03-28
ATE12769T1 (de) 1985-05-15
PT75329A (en) 1982-08-01
EP0071368A1 (en) 1983-02-09
NO157215C (no) 1988-02-10
PL139439B1 (en) 1987-01-31
FI822551L (fi) 1983-01-29
FI67545B (fi) 1984-12-31
SU1204134A3 (ru) 1986-01-07
GR76210B (es) 1984-08-03
NO157215B (no) 1987-11-02
DK160275B (da) 1991-02-18

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