DK159119C - Analogifremgangsmaade til fremstilling af syreadditionssalte af 3alfa-acyloxy-2beta,16beta-dipiperidino-5alfa-androstanderivater samt fremgangsmaade til fremstilling af farmaceutiske oploesninger deraf - Google Patents

Analogifremgangsmaade til fremstilling af syreadditionssalte af 3alfa-acyloxy-2beta,16beta-dipiperidino-5alfa-androstanderivater samt fremgangsmaade til fremstilling af farmaceutiske oploesninger deraf

Info

Publication number
DK159119C
DK159119C DK361779A DK361779A DK159119C DK 159119 C DK159119 C DK 159119C DK 361779 A DK361779 A DK 361779A DK 361779 A DK361779 A DK 361779A DK 159119 C DK159119 C DK 159119C
Authority
DK
Denmark
Prior art keywords
preparation
3alfa
5alfa
16beta
dipiperidino
Prior art date
Application number
DK361779A
Other languages
Danish (da)
English (en)
Other versions
DK361779A (da
DK159119B (da
Inventor
Ian Craig Carlyle
Thomas Sleigh
David Samuel Savage
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of DK361779A publication Critical patent/DK361779A/da
Publication of DK159119B publication Critical patent/DK159119B/da
Application granted granted Critical
Publication of DK159119C publication Critical patent/DK159119C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
DK361779A 1978-09-05 1979-08-29 Analogifremgangsmaade til fremstilling af syreadditionssalte af 3alfa-acyloxy-2beta,16beta-dipiperidino-5alfa-androstanderivater samt fremgangsmaade til fremstilling af farmaceutiske oploesninger deraf DK159119C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7835667 1978-09-05
GB7835667 1978-09-05

Publications (3)

Publication Number Publication Date
DK361779A DK361779A (da) 1980-03-06
DK159119B DK159119B (da) 1990-09-03
DK159119C true DK159119C (da) 1991-03-11

Family

ID=10499453

Family Applications (1)

Application Number Title Priority Date Filing Date
DK361779A DK159119C (da) 1978-09-05 1979-08-29 Analogifremgangsmaade til fremstilling af syreadditionssalte af 3alfa-acyloxy-2beta,16beta-dipiperidino-5alfa-androstanderivater samt fremgangsmaade til fremstilling af farmaceutiske oploesninger deraf

Country Status (20)

Country Link
US (2) US4237126A (es)
EP (1) EP0008824B1 (es)
JP (1) JPS5535098A (es)
AR (1) AR228728A1 (es)
AT (1) ATE921T1 (es)
AU (1) AU526270B2 (es)
CA (1) CA1134813A (es)
DE (1) DE2962627D1 (es)
DK (1) DK159119C (es)
ES (1) ES483894A1 (es)
FI (1) FI66881C (es)
GR (1) GR72520B (es)
HU (1) HU181847B (es)
IE (1) IE50376B1 (es)
IL (1) IL58080A (es)
NO (1) NO151367C (es)
NZ (1) NZ191462A (es)
PH (1) PH16041A (es)
PT (1) PT70126A (es)
ZA (1) ZA794371B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
US5238957A (en) * 1988-07-07 1993-08-24 Presidenza Del Consiglio Dei Ministri-Uffico Del Ministro Per Il Coordinamento Delle Iniziative Per La Ricerca Scientifica E Tecnologica Esters of 2,2-dimethyl-cyclopropane-carboxylic acid
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
US5767112A (en) * 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
US5553456A (en) * 1995-05-17 1996-09-10 Ramco, Inc. Clathrate freeze desalination apparatus and method
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
WO2006038047A1 (en) * 2004-10-07 2006-04-13 Richter Gedeon Vegyészeti Gyár Rt. Environment-friend process for the synthesis of quaternary ammonio-steroιds
HU0402017D0 (en) * 2004-10-07 2004-12-28 Richter Gedeon Vegyeszet Environment-friend process for the synthesis of quaternary ammonio-steroids
CA2605138A1 (en) * 2005-04-15 2006-10-26 Lyotropic Therapeutics, Inc. Formulations of quaternary ammonium neuromuscular blocking agents
DE102005030423A1 (de) * 2005-06-30 2007-01-04 Inresa Arzneimittel Gmbh Neue Formulierung für Vecuroniumbromid
ATE554769T1 (de) 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
CN116887840A (zh) * 2020-10-15 2023-10-13 江苏恩华络康药物研发有限公司 甾体季铵化合物及其制备方法、制剂和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
US4177190A (en) * 1975-08-01 1979-12-04 Richter Gedeon Vegyeszeti Gyar Rt. Diamino-androstanes and a process for the preparation of the said compounds
HU172522B (hu) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh 2beta, 16beta-diamino-androstana i ikh chetvertichnykh solej

Also Published As

Publication number Publication date
ZA794371B (en) 1980-08-27
IE50376B1 (en) 1986-04-16
ES483894A1 (es) 1980-09-01
JPS6245879B2 (es) 1987-09-29
DK361779A (da) 1980-03-06
NO151367C (no) 1985-03-27
NO792810L (no) 1980-03-06
PT70126A (en) 1979-09-01
GR72520B (es) 1983-11-16
IL58080A0 (en) 1979-12-30
US4237126A (en) 1980-12-02
FI66881B (fi) 1984-08-31
IE791593L (en) 1980-03-05
ATE921T1 (de) 1982-05-15
EP0008824A1 (en) 1980-03-19
IL58080A (en) 1982-12-31
CA1134813A (en) 1982-11-02
JPS5535098A (en) 1980-03-11
PH16041A (en) 1983-06-02
DE2962627D1 (en) 1982-06-09
NO151367B (no) 1984-12-17
EP0008824B1 (en) 1982-04-28
US4297351A (en) 1981-10-27
AU526270B2 (en) 1982-12-23
NZ191462A (en) 1982-03-16
FI66881C (fi) 1984-12-10
AU5034879A (en) 1980-03-13
FI792745A (fi) 1980-03-06
HU181847B (en) 1983-11-28
AR228728A1 (es) 1983-04-15
DK159119B (da) 1990-09-03

Similar Documents

Publication Publication Date Title
DK157860C (da) Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
DK81579A (da) Phenoxyalkylcarbonsyrederivater fremgangsmaade til deres fremstilling samt laegemidler indeholdende disse forbindelser
DK162714C (da) Analogifremgangsmaade til fremstilling af glycinamidderivater eller syreadditionssalte deraf
DK147362C (da) Analogifremgangsmaade til fremstilling af ergolen- eller ergolin-derivater eller syreadditionssalte deraf
DK149308C (da) Analogifremgangs-maade til fremstilling af trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamin-derivater eller farmaceutisk acceptablesyreadditionssalte deraf
DK151884C (da) Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK159119C (da) Analogifremgangsmaade til fremstilling af syreadditionssalte af 3alfa-acyloxy-2beta,16beta-dipiperidino-5alfa-androstanderivater samt fremgangsmaade til fremstilling af farmaceutiske oploesninger deraf
DK150483C (da) Analogifremgangsmaade til fremstilling af trans-3-(4-oxo-4h-quinazolin-3-yl)-2-propensyrederivater eller salte deraf med farmaceutisk acceptablesyrer
DK157862C (da) Analogifremgangsmaade til fremstilling af imidazolylphenylamidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK160045C (da) Analogifremgangsmaade til fremstilling af 4-oxo-4h-pyridooe1,2-aaapyrimidiner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere ammoniumsalte deraf
DK154950C (da) Analogifremgangsmaade til fremstilling af 1-(benzazolylalkyl)-piperidinderivater eller de farmaceutisk acceptable syreadditionssalte deraf
DK155670C (da) Analogifremgangsmaade til fremstilling af sesquiterpenderivater eller farmaceutisk acceptable salte deraf
DK158658C (da) Analogifremgangsmaade til fremstilling af 9-aminoalkylfluorener eller farmaceutisk acceptable salte deraf
DK151805C (da) Analogifremgangsmaade til fremstilling af 20,21-di-nor-eburnameninderivater eller farmaceutisk acceptable additionssalte deraf
DK149841C (da) Analogifremgangsmaade til fremstilling af alfa-fluor-methyl-alfa-aminoalkansyrer eller farmaceutisk acceptable syreadditionssalte deraf
DK149077C (da) Analogifremgangsmaade til fremstilling af encephalin-analoge pentapeptidamidderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK165005C (da) Analogifremgangsmaade til fremstilling af 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater eller terapeutisk acceptable salte deraf
DK160498C (da) Analogifremgangsmaade til fremstilling af 3-methyl-flavon-8-carboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf
DK144793C (da) Analogifremgangsmaade til fremstilling af dihydro- eller tetrahydroiminothiaziner eller farmaceutisk acceptable syreadditionssalte deraf
DK152427C (da) Analogifremgangsmaade til fremstilling af 4-thiomethylpyridinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK162102C (da) Analogifremgangsmaade til fremstilling af 3-o-(beta-d-glucoronopyranosyl)-sojasapogenol b eller farmaceutisk acceptable salte deraf
DK157023C (da) Analogifremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf
DK157021C (da) Analogifremgangsmaade til fremstilling af 2,3-polymethylen-4-oxo-4h-pyrido- eller -azepinooe1,2-aaapyrimidiner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf
DK149750C (da) Analogifremgangsmaade til fremstilling af n-alkenylmoranolin-derivater eller farmaceutiske acceptable syreadditionssalte deraf
DK151254C (da) Analogifremgangsmaade til fremstilling af 2-hydroxymethyl-pyrazin-derivater eller farmaceutisk acceptable salte deraf

Legal Events

Date Code Title Description
PUP Patent expired