DK1590360T3 - Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser - Google Patents

Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser

Info

Publication number
DK1590360T3
DK1590360T3 DK04706902.6T DK04706902T DK1590360T3 DK 1590360 T3 DK1590360 T3 DK 1590360T3 DK 04706902 T DK04706902 T DK 04706902T DK 1590360 T3 DK1590360 T3 DK 1590360T3
Authority
DK
Denmark
Prior art keywords
nucleosidases
inhibitors
preparation
nucleoside phosphorylases
phosphorylases
Prior art date
Application number
DK04706902.6T
Other languages
English (en)
Inventor
Gary Brian Evans
Peter Charles Tyler
Original Assignee
Ind Res Ltd
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Res Ltd, Einstein Coll Med filed Critical Ind Res Ltd
Application granted granted Critical
Publication of DK1590360T3 publication Critical patent/DK1590360T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK04706902.6T 2003-02-04 2004-01-30 Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser DK1590360T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ523970A NZ523970A (en) 2003-02-04 2003-02-04 Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
PCT/NZ2004/000017 WO2004069856A1 (en) 2003-02-04 2004-01-30 Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number Publication Date
DK1590360T3 true DK1590360T3 (da) 2012-08-27

Family

ID=32844996

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04706902.6T DK1590360T3 (da) 2003-02-04 2004-01-30 Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser

Country Status (16)

Country Link
US (2) US7655795B2 (da)
EP (1) EP1590360B1 (da)
JP (1) JP4806746B2 (da)
KR (1) KR101185120B1 (da)
CN (1) CN100357308C (da)
BR (1) BRPI0407210A (da)
CA (1) CA2514992C (da)
CY (1) CY1113297T1 (da)
DK (1) DK1590360T3 (da)
ES (1) ES2391043T3 (da)
HK (1) HK1089448A1 (da)
NZ (1) NZ523970A (da)
PT (1) PT1590360E (da)
RU (1) RU2334757C2 (da)
SI (1) SI1590360T1 (da)
WO (1) WO2004069856A1 (da)

Families Citing this family (22)

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US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
DK1165564T3 (da) * 1999-04-08 2009-06-08 Ind Res Ltd Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme
DK1539783T3 (da) 2002-08-21 2011-06-20 Einstein Coll Med Inhibitorer af nucleosidphosphorylaser og nucleosidaser
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
US8541567B2 (en) * 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8394950B2 (en) * 2006-02-22 2013-03-12 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
JP2009528996A (ja) * 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
DE602007013252D1 (de) 2006-09-07 2011-04-28 Einstein Coll Med Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen
WO2008030118A1 (en) * 2006-09-07 2008-03-13 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
ES2385759T3 (es) * 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
AU2010230008B2 (en) * 2009-03-24 2015-06-04 Biocryst Pharmaceuticals, Inc. Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1- ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
WO2011008110A1 (en) * 2009-07-17 2011-01-20 Albert Einstein College Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2014025842A1 (en) * 2012-08-07 2014-02-13 Albert Einstein College Of Medicine Of Yeshiva University Treatment of helicobacter pylori infections
CN111499639B (zh) * 2019-01-31 2022-03-04 四川大学华西医院 嘧啶酮衍生物及其在制药中的应用

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US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
WO1997031008A1 (en) 1996-02-23 1997-08-28 Industrial Research Limited Enzyme detection/assay method and substrates
KR100284413B1 (ko) * 1996-09-24 2001-03-02 고바야시 유키오 우라실 유도체를 함유하는 암전이 억제제유도체
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
DK1165564T3 (da) 1999-04-08 2009-06-08 Ind Res Ltd Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme
JP2004507534A (ja) 2000-08-29 2004-03-11 インダストリアル　リサーチ　リミテッド ヌクレオシド代謝阻害剤
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
DK1539783T3 (da) * 2002-08-21 2011-06-20 Einstein Coll Med Inhibitorer af nucleosidphosphorylaser og nucleosidaser
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (en) 2004-07-27 2009-07-15 Biocryst Pharm Inc 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYL THIOADENOSINE / S-ADENOSYLHOMOCYSTEIN NUCLEOSIDASE HEMMER
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
WO2008030118A1 (en) * 2006-09-07 2008-03-13 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2066671A1 (en) * 2006-09-26 2009-06-10 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
ES2385759T3 (es) * 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa

Also Published As

Publication number Publication date
RU2334757C2 (ru) 2008-09-27
HK1089448A1 (en) 2006-12-01
EP1590360B1 (en) 2012-07-11
EP1590360A1 (en) 2005-11-02
KR101185120B1 (ko) 2012-09-21
CN100357308C (zh) 2007-12-26
EP1590360A4 (en) 2009-06-24
PT1590360E (pt) 2012-08-27
US7655795B2 (en) 2010-02-02
SI1590360T1 (sl) 2012-11-30
JP2006516615A (ja) 2006-07-06
AU2004208968A1 (en) 2004-08-19
BRPI0407210A (pt) 2006-01-24
CN1771254A (zh) 2006-05-10
JP4806746B2 (ja) 2011-11-02
WO2004069856A1 (en) 2004-08-19
US20100094003A1 (en) 2010-04-15
ES2391043T3 (es) 2012-11-20
CA2514992C (en) 2012-08-07
RU2005127630A (ru) 2006-06-27
KR20050114614A (ko) 2005-12-06
NZ523970A (en) 2005-02-25
CA2514992A1 (en) 2004-08-19
CY1113297T1 (el) 2016-04-13
US20060217551A1 (en) 2006-09-28

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