DK1551835T3 - Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse - Google Patents

Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Info

Publication number
DK1551835T3
DK1551835T3 DK03798094T DK03798094T DK1551835T3 DK 1551835 T3 DK1551835 T3 DK 1551835T3 DK 03798094 T DK03798094 T DK 03798094T DK 03798094 T DK03798094 T DK 03798094T DK 1551835 T3 DK1551835 T3 DK 1551835T3
Authority
DK
Denmark
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
DK03798094T
Other languages
Danish (da)
English (en)
Inventor
Dan Neurosearch A S Peters
Gunnar M Olsen
Elsebet Stergaard Nielsen
Tino Dyhring Joergensen
Philip K Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1551835T3 publication Critical patent/DK1551835T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03798094T 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse DK1551835T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
DK1551835T3 true DK1551835T3 (da) 2007-06-04

Family

ID=32045613

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03798094T DK1551835T3 (da) 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Country Status (11)

Country Link
US (1) US7220741B2 (xx)
EP (2) EP1551835B1 (xx)
AT (2) ATE426602T1 (xx)
AU (1) AU2003266222B2 (xx)
CA (1) CA2496585C (xx)
DE (2) DE60311853T2 (xx)
DK (1) DK1551835T3 (xx)
ES (1) ES2280836T3 (xx)
NZ (1) NZ538512A (xx)
PL (1) PL375025A1 (xx)
WO (1) WO2004029053A1 (xx)

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BRPI0516609A (pt) * 2004-10-18 2008-04-29 Amgen Inc composto ou sal, hidrato, ou estereoisÈmero farmaceuticamente aceitáveis do mesmo, composição farmacêutica, e, uso de um composto
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ATE495178T1 (de) 2005-02-16 2011-01-15 Neurosearch As Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
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CA2647601A1 (en) 2006-06-27 2008-01-03 Abbott Laboratories Pyrrole derivatives and their methods of use
CN101479262A (zh) 2006-06-27 2009-07-08 艾博特公司 噻唑啉和唑啉衍生物及其应用方法
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
JP2010519193A (ja) * 2007-02-15 2010-06-03 アージェンタ ディスカバリー リミテッド Ｍ３ムスカリン受容体としての複素環式誘導体
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EP2190847A1 (en) * 2007-08-17 2010-06-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as nicotinic acetylcholine receptor ligands
MX2010001638A (es) * 2007-08-17 2010-03-15 Neurosearch As Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico.
DE102007053771A1 (de) * 2007-11-12 2009-05-14 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtungen
CA2705752A1 (en) * 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
US20100305108A1 (en) * 2007-11-14 2010-12-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
GB0723719D0 (en) * 2007-12-04 2008-01-16 Glaxo Group Ltd Compounds
GB0723814D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
AU2009212259A1 (en) 2008-02-07 2009-08-13 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
MX2010009580A (es) * 2008-03-11 2010-09-24 Neurosearch As Nuevos derivados 1,4-diaza-biciclo[3.2.2]nonil-oxadiazolilo utiles como moduladores de los receptores nicotinicos de acetilcolina.
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
US20110263577A1 (en) * 2008-10-13 2011-10-27 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
WO2010084120A1 (en) 2009-01-21 2010-07-29 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
US20120028967A1 (en) 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
EP2389380A1 (en) * 2009-01-26 2011-11-30 NeuroSearch A/S N-oxides of diazabicyclononyl pyrimidine derivatives and their medical use
CN102300574A (zh) 2009-01-26 2011-12-28 神经研究公司 新的吲哚基-*二唑基-二氮杂二环壬烷衍生物及它们的医药和诊断用途
US20120238553A1 (en) 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
EP2498826A1 (en) 2009-11-11 2012-09-19 NeuroSearch AS Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
US8946412B2 (en) 2009-12-18 2015-02-03 Danpet Ab Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
WO2012139925A1 (en) 2011-04-15 2012-10-18 Neurosearch A/S Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN105037343B (zh) * 2015-05-27 2018-02-02 山东师范大学 有机配体和Cu(I)双金属硫杂冠醚大环的合成方法
DK3386511T3 (da) 2015-12-10 2021-07-05 Ptc Therapeutics Inc Fremgangsmåder til behandling af huntingtons sygdom
EP3634953B1 (en) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
WO2019005980A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
EP3645121A4 (en) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. HUNTINGTON'S DISEASE TREATMENT METHODS
EP3661509A4 (en) 2017-08-04 2021-01-13 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING THE SPLICE
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
AU2019294478B2 (en) 2018-06-27 2023-03-23 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease
JP2022521467A (ja) 2019-02-05 2022-04-08 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
EP3920928A4 (en) 2019-02-06 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING

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US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
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Also Published As

Publication number Publication date
EP1785425B1 (en) 2009-03-25
WO2004029053A1 (en) 2004-04-08
AU2003266222A1 (en) 2004-04-19
PL375025A1 (en) 2005-11-14
EP1785425A3 (en) 2007-06-06
EP1551835B1 (en) 2007-02-14
ATE426602T1 (de) 2009-04-15
DE60326894D1 (de) 2009-05-07
EP1551835A1 (en) 2005-07-13
US7220741B2 (en) 2007-05-22
CA2496585C (en) 2012-05-29
ATE353899T1 (de) 2007-03-15
DE60311853D1 (de) 2007-03-29
NZ538512A (en) 2006-12-22
AU2003266222B2 (en) 2009-10-01
EP1785425A2 (en) 2007-05-16
US20060122172A1 (en) 2006-06-08
CA2496585A1 (en) 2004-04-08
DE60311853T2 (de) 2007-06-21
ES2280836T3 (es) 2007-09-16

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