DK1549353T3 - Anvendelse af alfa(1,3)galactosyltransferaseudtrykkende allogene tumorceller til vaccination mod tumorer - Google Patents
Anvendelse af alfa(1,3)galactosyltransferaseudtrykkende allogene tumorceller til vaccination mod tumorerInfo
- Publication number
- DK1549353T3 DK1549353T3 DK03779090.4T DK03779090T DK1549353T3 DK 1549353 T3 DK1549353 T3 DK 1549353T3 DK 03779090 T DK03779090 T DK 03779090T DK 1549353 T3 DK1549353 T3 DK 1549353T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- tumor
- tumor cells
- galactosyltransferase
- alpha
- Prior art date
Links
- 210000004881 tumor cell Anatomy 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 102000030902 Galactosyltransferase Human genes 0.000 title 1
- 108060003306 Galactosyltransferase Proteins 0.000 title 1
- 230000000735 allogeneic effect Effects 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 125000003169 alpha-Gal epitope group Chemical group [C@H]1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)O[C@@H]1[C@H]([C@@H](O[C@@H]([C@@H]1O)CO)O[C@H]1[C@@H]([C@H](C(O[C@@H]1CO)*)NC(C)=O)O)O 0.000 abstract 1
- 230000030741 antigen processing and presentation Effects 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000014207 opsonization Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000005909 tumor killing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464454—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41734302P | 2002-10-09 | 2002-10-09 | |
| PCT/US2003/032036 WO2004032865A2 (en) | 2002-10-09 | 2003-10-09 | Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1549353T3 true DK1549353T3 (da) | 2010-07-12 |
Family
ID=32094006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03779090.4T DK1549353T3 (da) | 2002-10-09 | 2003-10-09 | Anvendelse af alfa(1,3)galactosyltransferaseudtrykkende allogene tumorceller til vaccination mod tumorer |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US20040191229A1 (da) |
| EP (1) | EP1549353B1 (da) |
| JP (1) | JP4966496B2 (da) |
| CN (2) | CN1756568A (da) |
| AT (1) | ATE462449T1 (da) |
| AU (1) | AU2003285863A1 (da) |
| CA (1) | CA2501744C (da) |
| DE (1) | DE60331933D1 (da) |
| DK (1) | DK1549353T3 (da) |
| ES (1) | ES2341335T3 (da) |
| HK (1) | HK1215044A1 (da) |
| MX (1) | MXPA05003705A (da) |
| WO (1) | WO2004032865A2 (da) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1054683B1 (en) | 1998-02-20 | 2007-04-11 | University Of Miami | Modified heat shock protein-antigenic peptide complex |
| US20050201993A1 (en) * | 2002-10-09 | 2005-09-15 | Link Charles J.Jr. | Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase |
| MXPA05003705A (es) | 2002-10-09 | 2005-08-16 | Central Iowa Health System | Vacunacion antitumoral usando celulas de tumor alogeneico que expresan alfa (1,3)-galactosil transferasa. |
| CN101052709B (zh) * | 2004-10-25 | 2012-06-27 | 贝勒研究院 | 装载热激黑素瘤细胞体的树突细胞 |
| US7820628B2 (en) * | 2005-02-22 | 2010-10-26 | University Of Massachusetts Medical School | Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding |
| US7713266B2 (en) | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
| US7850683B2 (en) * | 2005-05-20 | 2010-12-14 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
| US7998486B2 (en) | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
| US9254162B2 (en) | 2006-12-21 | 2016-02-09 | Myoscience, Inc. | Dermal and transdermal cryogenic microprobe systems |
| US8409185B2 (en) | 2007-02-16 | 2013-04-02 | Myoscience, Inc. | Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling |
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| WO2009065061A1 (en) | 2007-11-14 | 2009-05-22 | Myoscience, Inc. | Pain management using cryogenic remodeling |
| US20100112702A1 (en) * | 2008-02-25 | 2010-05-06 | Klein Benjamin Y | Method designed to divert glucose away from the glycolytic pathway |
| DK2257301T3 (da) | 2008-03-03 | 2014-04-28 | Univ Miami | Immunterapi baseret på allogene cancerceller. |
| WO2009117116A2 (en) | 2008-03-20 | 2009-09-24 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| JP2012503471A (ja) * | 2008-05-30 | 2012-02-09 | グライコフィ， インコーポレイテッド | 末端アルファ−１，３−結合ガラクトースを有するタンパク質の製造のための酵母株 |
| CN102223894A (zh) * | 2008-11-21 | 2011-10-19 | 迈阿密大学 | 用于产生粘膜和系统免疫的hiv/siv疫苗 |
| ES2427980T3 (es) | 2008-12-22 | 2013-11-05 | Myoscience, Inc. | Sistema crioquirúrgico integrado con refrigerante y fuente de energía eléctrica |
| CN102695807B (zh) * | 2009-11-10 | 2016-02-24 | 雀巢产品技术援助有限公司 | 心脏衰老生物标志物及其用途 |
| US20110150934A1 (en) * | 2009-12-18 | 2011-06-23 | University Of Notre Dame | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer |
| WO2011079070A1 (en) * | 2009-12-23 | 2011-06-30 | Gradalis, Inc. | Furin-knockdown bi-functional rna |
| SG10201606680QA (en) | 2009-12-23 | 2016-10-28 | Gradalis Inc | Furin-knockdown and gm-csf-augmented (fang) cancer vaccine |
| CN102711794B (zh) * | 2010-01-04 | 2015-11-25 | Kj生物科学有限公司 | 用于疫苗和诊断学的Dps融合蛋白 |
| CN102286428A (zh) * | 2011-06-04 | 2011-12-21 | 内蒙古医学院 | 一种在肿瘤细胞表面合成α-半乳糖苷表位并激活免疫细胞的方法 |
| CN102716497A (zh) * | 2011-07-07 | 2012-10-10 | 赵永祥 | α1,3半乳糖基转移酶基因转染材料及其制备方法和应用 |
| EP2802279B1 (en) | 2012-01-13 | 2017-08-16 | Myoscience, Inc. | Cryogenic needle with freeze zone regulation |
| CA2860893A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
| CA2861116A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Cryogenic probe filtration system |
| US9017318B2 (en) | 2012-01-20 | 2015-04-28 | Myoscience, Inc. | Cryogenic probe system and method |
| CN102760208B (zh) * | 2012-07-03 | 2015-07-29 | 清华大学 | 基于模拟疫苗的动态人工免疫故障诊断方法 |
| WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
| US9295512B2 (en) | 2013-03-15 | 2016-03-29 | Myoscience, Inc. | Methods and devices for pain management |
| US20160022826A1 (en) * | 2013-03-15 | 2016-01-28 | Newlink Genetics Corporation | Carbohydrate-modified glycoproteins and uses thereof |
| WO2014146127A1 (en) | 2013-03-15 | 2014-09-18 | Myoscience, Inc. | Methods and systems for treatment of spasticity |
| US20140350536A1 (en) | 2013-03-15 | 2014-11-27 | Myoscience, Inc. | Cryogenic Blunt Dissection Methods and Devices |
| US9610112B2 (en) | 2013-03-15 | 2017-04-04 | Myoscience, Inc. | Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis |
| EP2996716A4 (en) * | 2013-05-15 | 2017-01-25 | Newlink Genetics Corporation | Correlates of efficacy relating to tumor vaccines |
| WO2015069792A1 (en) | 2013-11-05 | 2015-05-14 | Myoscience, Inc. | Secure cryosurgical treatment system |
| ES2845727T3 (es) | 2015-02-06 | 2021-07-27 | Heat Biologics Inc | Vector que coexpresa una vacuna y moléculas coestimuladoras |
| GB201505860D0 (en) * | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
| EP3454762B1 (en) | 2016-05-13 | 2024-04-03 | Pacira CryoTech, Inc. | Systems for locating and treating with cold therapy |
| CA3040123A1 (en) | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| US11548930B2 (en) | 2017-04-04 | 2023-01-10 | Heat Biologics, Inc. | Intratumoral vaccination |
| US11896653B2 (en) | 2017-09-13 | 2024-02-13 | Unm Rainforest Innovations | Silicified cell replicas, methods of making, and methods of using |
| EP3709918A4 (en) | 2017-11-15 | 2021-08-11 | Pacira CryoTech, Inc. | INTEGRATED COLD THERAPY AND ELECTRIC STIMULATION SYSTEMS FOR LOCALIZATION AND TREATMENT OF NERVE AND RELATED PROCEDURES |
| US20220282220A1 (en) * | 2019-07-24 | 2022-09-08 | Sl Bigen Inc. | Method for preparation of immortalized stem cell line and use thereof |
| TW202134430A (zh) | 2019-12-03 | 2021-09-16 | 美商紐沃進公司 | 腫瘤細胞疫苗 |
| WO2021139810A1 (en) * | 2020-01-10 | 2021-07-15 | The University Of Hong Kong | Recombinant viruses expressing alpha-1, 3-galactosyltransferase and uses thereof |
| US20230149456A1 (en) * | 2020-03-30 | 2023-05-18 | Unm Rainforest Innovations | Nanoparticle-loaded silicified cells, methods of making, and methods of use |
| WO2022256360A1 (en) * | 2021-06-02 | 2022-12-08 | Neuvogen, Inc. | Tumor cell vaccines |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879675A (en) * | 1994-03-15 | 1999-03-09 | Medical College Of Pennsylvania And Hahnemann University | Compositions and methods for vaccines comprising α-galactosyl epitopes |
| US6218166B1 (en) * | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| JP2001517206A (ja) * | 1996-08-16 | 2001-10-02 | ザ ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン | 免疫優性な共有黒色腫抗原を発現する黒色腫細胞株およびその使用方法 |
| US5869035A (en) * | 1996-11-13 | 1999-02-09 | Human Gene Therapy Research Institute | Methods and compositions for inducing complement destruction of tissue |
| EP1119365A4 (en) * | 1997-07-24 | 2003-08-13 | Univ Jefferson | COMPOSITIONS AND METHODS FOR USING TUMOR CELLS |
| US7005126B1 (en) * | 1999-06-08 | 2006-02-28 | Human Gene Therapy Research Institute | Method for tumor treatment using infusion of xenogeneic cells to induce hyperacute rejection and innocent bystander effect |
| US7101543B2 (en) * | 2000-03-31 | 2006-09-05 | Novarx | Genetically modified cells expressing a TGFβ inhibitor, the cells being lung cancer cells |
| AU2002235141A1 (en) * | 2000-11-27 | 2002-06-03 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
| US20050201993A1 (en) * | 2002-10-09 | 2005-09-15 | Link Charles J.Jr. | Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase |
| MXPA05003705A (es) | 2002-10-09 | 2005-08-16 | Central Iowa Health System | Vacunacion antitumoral usando celulas de tumor alogeneico que expresan alfa (1,3)-galactosil transferasa. |
-
2003
- 2003-10-09 MX MXPA05003705A patent/MXPA05003705A/es active IP Right Grant
- 2003-10-09 DE DE60331933T patent/DE60331933D1/de not_active Expired - Lifetime
- 2003-10-09 CN CNA2003801011520A patent/CN1756568A/zh active Pending
- 2003-10-09 DK DK03779090.4T patent/DK1549353T3/da active
- 2003-10-09 ES ES03779090T patent/ES2341335T3/es not_active Expired - Lifetime
- 2003-10-09 CA CA2501744A patent/CA2501744C/en not_active Expired - Fee Related
- 2003-10-09 JP JP2004543606A patent/JP4966496B2/ja not_active Expired - Fee Related
- 2003-10-09 AU AU2003285863A patent/AU2003285863A1/en not_active Abandoned
- 2003-10-09 EP EP03779090A patent/EP1549353B1/en not_active Expired - Lifetime
- 2003-10-09 WO PCT/US2003/032036 patent/WO2004032865A2/en active Application Filing
- 2003-10-09 US US10/682,178 patent/US20040191229A1/en not_active Abandoned
- 2003-10-09 AT AT03779090T patent/ATE462449T1/de active
- 2003-10-09 CN CN201510381454.2A patent/CN104911210A/zh active Pending
-
2006
- 2006-09-19 US US11/533,184 patent/US7763461B2/en not_active Expired - Fee Related
- 2006-09-19 US US11/533,199 patent/US20070014775A1/en not_active Abandoned
-
2010
- 2010-09-09 US US12/878,756 patent/US8535658B2/en not_active Expired - Fee Related
-
2013
- 2013-08-14 US US13/966,446 patent/US9474801B2/en not_active Expired - Fee Related
-
2016
- 2016-03-14 HK HK16102936.5A patent/HK1215044A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1549353A2 (en) | 2005-07-06 |
| US20110250233A1 (en) | 2011-10-13 |
| US20070014775A1 (en) | 2007-01-18 |
| WO2004032865A2 (en) | 2004-04-22 |
| US9474801B2 (en) | 2016-10-25 |
| ES2341335T3 (es) | 2010-06-18 |
| US20040191229A1 (en) | 2004-09-30 |
| JP2006507267A (ja) | 2006-03-02 |
| US20140037692A1 (en) | 2014-02-06 |
| CN1756568A (zh) | 2006-04-05 |
| EP1549353B1 (en) | 2010-03-31 |
| US7763461B2 (en) | 2010-07-27 |
| CN104911210A (zh) | 2015-09-16 |
| WO2004032865A3 (en) | 2004-06-10 |
| US8535658B2 (en) | 2013-09-17 |
| CA2501744C (en) | 2012-01-03 |
| AU2003285863A8 (en) | 2004-05-04 |
| AU2003285863A1 (en) | 2004-05-04 |
| MXPA05003705A (es) | 2005-08-16 |
| US20070014774A1 (en) | 2007-01-18 |
| DE60331933D1 (de) | 2010-05-12 |
| CA2501744A1 (en) | 2004-04-22 |
| HK1215044A1 (zh) | 2016-08-12 |
| ATE462449T1 (de) | 2010-04-15 |
| WO2004032865A9 (en) | 2004-07-22 |
| JP4966496B2 (ja) | 2012-07-04 |
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