SG10201606680QA - Furin-knockdown and gm-csf-augmented (fang) cancer vaccine - Google Patents

Furin-knockdown and gm-csf-augmented (fang) cancer vaccine

Info

Publication number
SG10201606680QA
SG10201606680QA SG10201606680QA SG10201606680QA SG10201606680QA SG 10201606680Q A SG10201606680Q A SG 10201606680QA SG 10201606680Q A SG10201606680Q A SG 10201606680QA SG 10201606680Q A SG10201606680Q A SG 10201606680QA SG 10201606680Q A SG10201606680Q A SG 10201606680QA
Authority
SG
Singapore
Prior art keywords
furin
knockdown
fang
csf
augmented
Prior art date
Application number
SG10201606680QA
Inventor
John J Nemunaitis
Neil Senzer
Phillip B Maples
Donald Rao
Original Assignee
Gradalis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gradalis Inc filed Critical Gradalis Inc
Publication of SG10201606680QA publication Critical patent/SG10201606680QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001139—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
SG10201606680QA 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine SG10201606680QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28968109P 2009-12-23 2009-12-23
US30977710P 2010-03-02 2010-03-02

Publications (1)

Publication Number Publication Date
SG10201606680QA true SG10201606680QA (en) 2016-10-28

Family

ID=44196113

Family Applications (3)

Application Number Title Priority Date Filing Date
SG2012046330A SG181880A1 (en) 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
SG10201606680QA SG10201606680QA (en) 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
SG2013011713A SG188160A1 (en) 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012046330A SG181880A1 (en) 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013011713A SG188160A1 (en) 2009-12-23 2010-12-20 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine

Country Status (13)

Country Link
US (4) US9132146B2 (en)
EP (1) EP2515916B1 (en)
JP (2) JP5553906B2 (en)
KR (2) KR101548567B1 (en)
CN (2) CN102917709B (en)
AR (1) AR081057A1 (en)
AU (1) AU2010333753B2 (en)
CA (1) CA2785258A1 (en)
HK (1) HK1258331A1 (en)
IL (1) IL220589A0 (en)
SG (3) SG181880A1 (en)
TW (2) TW201522632A (en)
WO (1) WO2011079077A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603991B2 (en) 2005-11-18 2013-12-10 Gradalis, Inc. Individualized cancer therapy
US9157084B2 (en) 2009-12-23 2015-10-13 Gradalis, Inc. Furin-knockdown bi-functional RNA
CA2785258A1 (en) 2009-12-23 2011-06-30 Gradalis, Inc. Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
US8946186B2 (en) 2010-09-20 2015-02-03 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University QSOX1 as an anti-neoplastic drug target
US20140141015A1 (en) 2010-09-20 2014-05-22 Douglas Lake QSOX1 as an Anti-Neoplastic Drug Target
WO2013115579A1 (en) * 2012-01-31 2013-08-08 연세대학교 산학협력단 Shrna for suppressing tgf-β2 expression
US9890215B2 (en) * 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
US20160024600A1 (en) * 2013-03-15 2016-01-28 The United States of America, as represented by the Secretary, Department of Health and Human Ser Coincidence reporter gene system
CN110835376B (en) * 2013-07-18 2023-08-04 弗拉芒区生物技术研究所 Fusion factors involving cytokines with strongly reduced receptor binding affinities
WO2015148683A1 (en) * 2014-03-26 2015-10-01 Tocagen Inc. A retroviral vector having immune-stimulating activity
WO2015152609A1 (en) * 2014-03-31 2015-10-08 연세대학교 산학협력단 Antitumor composition containing gm-csf gene, decorin gene, shrna inhibiting tgf-β2 expression, and shrna inhibiting foxp3 expression
KR101713407B1 (en) * 2014-03-31 2017-03-07 연세대학교 산학협력단 Melanoma cell line capable of adenoviral infection and replication
CN106661576A (en) * 2014-04-25 2017-05-10 斯特里克生物公司 Multiple targeted rnai for the treatment of cancers
US11020455B2 (en) 2015-07-30 2021-06-01 Endor Technologies, S.L Colony stimulating factor for use in pancreatic or colon cancer treatment
EP3388522B1 (en) * 2015-12-08 2020-08-12 University-Industry Foundation, Yonsei University Antitumor composition comprising gm-csf gene, flt3l-trail fusion gene, shrna inhibiting tgf- expression, and shrna inhibiting hsp expression
CN105734080A (en) * 2016-01-30 2016-07-06 山西大学 Targeting anticancer gene-plasmid as well as construction method and application thereof
EP3954766A1 (en) * 2017-10-10 2022-02-16 NantBio, Inc. Modified ec7 cells having low toxicity to viral production payloads
WO2020048942A1 (en) * 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
CN109160888B (en) * 2018-10-09 2022-03-01 四川医立特生物医药有限公司 Amidino-containing symmetrical compound and application thereof
JP7211139B2 (en) * 2019-02-14 2023-01-24 日本電信電話株式会社 Review method, information processing device and review program
CN110760477A (en) * 2019-10-10 2020-02-07 杭州广科安德生物科技有限公司 Establishment method of mouse liver high-metastasis intestinal cancer cell strain, cell strain and application
EP4069284A1 (en) 2019-12-03 2022-10-12 Neuvogen, Inc. Tumor cell vaccines
CA3158900A1 (en) * 2020-01-13 2021-07-22 John Nemunaitis Methods for treating cancers using gm-csf encoding polynucleotide and additional agents
WO2021146213A1 (en) * 2020-01-13 2021-07-22 Gradalis, Inc. Methods for treating cancers using gm-csf encoding polynucleotide and additional agents
EP4158025A1 (en) * 2020-05-26 2023-04-05 Gradalis, Inc. Methods for the treatment of viral respiratory infections
WO2022055817A1 (en) 2020-09-09 2022-03-17 Gradalis, Inc. Composition formulated into inhalable dosage forms for the treatment of lung|tumors
CN117136237A (en) * 2021-03-10 2023-11-28 格兰达利斯有限公司 Methods for treating cancer

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3545568A1 (en) * 1985-12-21 1987-07-16 Hoechst Ag GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US8119395B1 (en) * 1998-02-27 2012-02-21 The Trustees Of The University Of Pennsylvania Vaccines, immunotherapeutics and methods for using the same
US8791081B2 (en) 1999-08-13 2014-07-29 Case Western Reserve University MGMT inhibitor combination for the treatment of neoplastic disorders
BRPI0115814B8 (en) 2000-12-01 2021-05-25 Europaeisches Laboratorium Fuer Molekularbiologie Embl double-stranded RNA molecules, their method of preparation and pharmaceutical composition comprising them
AU2002306768A1 (en) 2001-03-20 2002-10-03 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
US20050143333A1 (en) 2001-05-18 2005-06-30 Sirna Therapeutics, Inc. RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
US20050080031A1 (en) 2001-05-18 2005-04-14 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV
BR0211111A (en) 2001-07-12 2004-06-22 Univ Massachusetts Isolated nucleic acid molecule, vector, host cell, transgene, engineered rna precursor, non-human transgenic animal, and method of inducing ribonucleic acid interference from a target gene in a cell
US20030144823A1 (en) 2001-11-01 2003-07-31 Fox Jeffrey J. Scale-free network inference methods
AU2002348163A1 (en) 2001-11-02 2003-05-19 Intradigm Corporation Therapeutic methods for nucleic acid delivery vehicles
WO2003070966A2 (en) 2002-02-20 2003-08-28 Sirna Therapeutics, Inc RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20040023390A1 (en) 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
WO2004021144A2 (en) 2002-08-29 2004-03-11 Gene Network Sciences, Inc. Systems and methods for inferring biological networks
MXPA05003705A (en) 2002-10-09 2005-08-16 Central Iowa Health System Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase.
US20040088116A1 (en) 2002-11-04 2004-05-06 Gene Network Sciences, Inc. Methods and systems for creating and using comprehensive and data-driven simulations of biological systems for pharmacological and industrial applications
AU2004206232A1 (en) 2003-01-17 2004-08-05 University Of Florida Research Foundation Inc. Small interference RNA gene therapy
US20040213764A1 (en) 2003-03-28 2004-10-28 William Wold Adenovirus replication-competent vectors expressing trail
JP2009513487A (en) 2003-06-27 2009-04-02 サイレンス・セラピューティクス・アーゲー Use of double-stranded ribonucleic acid to induce cell lysis
BRPI0417213A (en) 2003-12-24 2007-02-06 Scios Inc treatment of malignant gliomas with tgf-beta inhibitors
US20050146081A1 (en) 2004-01-07 2005-07-07 Maclean David Needle protection device with gauge specific color coding and method for manufacturing thereof
US20070224194A1 (en) 2004-05-20 2007-09-27 Ludwig Institute For Cancer Research Methods for Inhibiting Angiogenesis and/or Lymphangiogenesis
WO2005112971A1 (en) 2004-05-20 2005-12-01 Ludwig Institute For Cancer Research Method for inhibiting angiogenesis and/or lymphangiogenesis
JP2008504840A (en) 2004-06-30 2008-02-21 アルニラム ファーマスーティカルズ インコーポレイテッド Oligonucleotides containing non-phosphate backbone bonds
EP2298897B1 (en) 2004-09-02 2013-08-14 Yale University Regulation of oncogenes by microRNAs
CN101120086A (en) 2005-02-16 2008-02-06 昆士兰医学研究所理事会 Flavivirus replicon constructs for tumour therapy
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
EP2311986B1 (en) 2005-07-27 2015-04-15 Oncotherapy Science, Inc. Method of diagnosing esophageal cancer
US8916530B2 (en) 2005-11-18 2014-12-23 Gradalis, Inc. Individualized cancer therapy
US8603991B2 (en) 2005-11-18 2013-12-10 Gradalis, Inc. Individualized cancer therapy
US8252526B2 (en) 2006-11-09 2012-08-28 Gradalis, Inc. ShRNA molecules and methods of use thereof
US8906874B2 (en) 2006-11-09 2014-12-09 Gradalis, Inc. Bi-functional shRNA targeting Stathmin 1 and uses thereof
US8758998B2 (en) 2006-11-09 2014-06-24 Gradalis, Inc. Construction of bifunctional short hairpin RNA
US20090163431A1 (en) 2007-02-14 2009-06-25 Ontherex Llc Compositions and methods for modulation of pdx-1
CA2688232A1 (en) * 2007-05-25 2008-12-04 Induce Biologics Inc. A method of enhancing recombinant protein production
WO2009002462A1 (en) 2007-06-22 2008-12-31 The Board Of Trustees Of The Leland Stanford Junior University Pre-mirna loop-modulated target regulation
NZ589880A (en) 2008-06-16 2012-10-26 Immunogen Inc Use of synergistic anti-cancer compositions comprising lenalidomide, at least one corticosteroid and at least one immunoconjugate
US20110045534A1 (en) * 2009-08-20 2011-02-24 Cell Signaling Technology, Inc. Nucleic Acid Cassette For Producing Recombinant Antibodies
WO2011053660A2 (en) 2009-10-30 2011-05-05 Gradalis, Inc. Novel therapeutic rna interference technology targeted to the pdx-1 oncogene in pdx-1 expressing neuroendocrine tumors
US9157084B2 (en) 2009-12-23 2015-10-13 Gradalis, Inc. Furin-knockdown bi-functional RNA
CA2785258A1 (en) 2009-12-23 2011-06-30 Gradalis, Inc. Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
US20110286979A1 (en) 2010-05-20 2011-11-24 Gradalis, Inc. CHEMOSENSITIZATION BY BI-FUNCTIONAL SMALL HAIRPIN RNA (bi-shRNA)
CA2872930A1 (en) 2012-05-09 2013-11-14 Gradalis, Inc. Bi-functional short-hairpin rna (bi-shrna) specific for single-nucleotide kras mutations

Also Published As

Publication number Publication date
EP2515916A1 (en) 2012-10-31
US20180073038A1 (en) 2018-03-15
JP2013515731A (en) 2013-05-09
AU2010333753B2 (en) 2013-06-13
US10253331B2 (en) 2019-04-09
KR20120099503A (en) 2012-09-10
EP2515916B1 (en) 2016-03-09
CN102917709B (en) 2018-04-24
US20150329873A1 (en) 2015-11-19
US20110262408A1 (en) 2011-10-27
HK1258331A1 (en) 2019-11-08
KR101589951B1 (en) 2016-01-29
CN108295087A (en) 2018-07-20
JP5820506B2 (en) 2015-11-24
AR081057A1 (en) 2012-06-06
JP5553906B2 (en) 2014-07-23
US9790518B2 (en) 2017-10-17
EP2515916A4 (en) 2013-10-23
KR101548567B1 (en) 2015-09-01
SG181880A1 (en) 2012-07-30
CN108295087B (en) 2021-01-15
WO2011079077A1 (en) 2011-06-30
US20130078279A1 (en) 2013-03-28
TW201130975A (en) 2011-09-16
JP2014210781A (en) 2014-11-13
KR20140108344A (en) 2014-09-05
CN102917709A (en) 2013-02-06
AU2010333753A1 (en) 2012-07-19
SG188160A1 (en) 2013-03-28
CA2785258A1 (en) 2011-06-30
IL220589A0 (en) 2012-08-30
TW201522632A (en) 2015-06-16
US9132146B2 (en) 2015-09-15

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