DK1546151T3 - Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner - Google Patents

Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner

Info

Publication number
DK1546151T3
DK1546151T3 DK03795686T DK03795686T DK1546151T3 DK 1546151 T3 DK1546151 T3 DK 1546151T3 DK 03795686 T DK03795686 T DK 03795686T DK 03795686 T DK03795686 T DK 03795686T DK 1546151 T3 DK1546151 T3 DK 1546151T3
Authority
DK
Denmark
Prior art keywords
disorder
benzodioxanes
heterocycle
annealed
anxiety
Prior art date
Application number
DK03795686T
Other languages
English (en)
Inventor
Gary Paul Stack
Deborah Ann Evrard
Uresh Shantilal Shah
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1546151T3 publication Critical patent/DK1546151T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK03795686T 2002-09-12 2003-09-11 Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner DK1546151T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41007202P 2002-09-12 2002-09-12
US10/659,174 US6911445B2 (en) 2002-09-12 2003-09-10 Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans

Publications (1)

Publication Number Publication Date
DK1546151T3 true DK1546151T3 (da) 2006-07-31

Family

ID=31997897

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03795686T DK1546151T3 (da) 2002-09-12 2003-09-11 Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner

Country Status (21)

Country Link
US (1) US6911445B2 (da)
EP (1) EP1546151B1 (da)
JP (1) JP2006503040A (da)
KR (1) KR20050042187A (da)
CN (1) CN1309722C (da)
AT (1) ATE323094T1 (da)
AU (1) AU2003266029A1 (da)
BR (1) BR0314430A (da)
CA (1) CA2498131A1 (da)
DE (1) DE60304590T2 (da)
DK (1) DK1546151T3 (da)
EC (1) ECSP055659A (da)
ES (1) ES2259776T3 (da)
HK (1) HK1073849A1 (da)
MX (1) MXPA05002838A (da)
NO (1) NO20051770L (da)
NZ (1) NZ539253A (da)
PT (1) PT1546151E (da)
RU (1) RU2005107591A (da)
SI (1) SI1546151T1 (da)
WO (1) WO2004024732A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
GT200600078A (es) * 2005-02-17 2007-04-12 Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquil condensados
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US20080139546A1 (en) * 2006-09-29 2008-06-12 Wyeth Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
PE20090759A1 (es) * 2007-05-30 2009-07-20 Wyeth Corp Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) * 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
AU3476599A (en) * 1998-04-08 1999-10-25 American Home Products Corporation Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression (5-ht1 receptor antagonists)
US6162803A (en) * 1998-04-08 2000-12-19 American Home Products Corp. Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
SI1392697T1 (en) 2001-03-14 2005-02-28 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino 2,3-f)quinoline
DK1381613T3 (da) 2001-04-26 2005-01-24 Wyeth Corp Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner

Also Published As

Publication number Publication date
US20040171667A1 (en) 2004-09-02
US6911445B2 (en) 2005-06-28
PT1546151E (pt) 2006-07-31
NO20051770L (no) 2005-06-07
JP2006503040A (ja) 2006-01-26
DE60304590D1 (de) 2006-05-24
CA2498131A1 (en) 2004-03-25
EP1546151B1 (en) 2006-04-12
CN1309722C (zh) 2007-04-11
KR20050042187A (ko) 2005-05-04
NZ539253A (en) 2006-09-29
ES2259776T3 (es) 2006-10-16
WO2004024732A1 (en) 2004-03-25
EP1546151A1 (en) 2005-06-29
BR0314430A (pt) 2005-09-27
SI1546151T1 (sl) 2006-08-31
MXPA05002838A (es) 2005-08-16
ECSP055659A (es) 2005-07-06
ATE323094T1 (de) 2006-04-15
CN1681821A (zh) 2005-10-12
AU2003266029A1 (en) 2004-04-30
HK1073849A1 (en) 2005-10-21
RU2005107591A (ru) 2006-01-20
DE60304590T2 (de) 2007-05-10

Similar Documents

Publication Publication Date Title
ECSP055659A (es) Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclos
NO20051769L (no) Antidepressivt virkende azaheterocykylmetylderivater av heterocykluskondenserte benzodioksaner
NO20051768D0 (no) Antidepressive indolalkylderivater av heterocykliske, kondenserte benzodioksanmetylaminer
BRPI0516735B8 (pt) métodos para produção de (r)-2-acetamido-n-benzil-3-metoxipropionamida (lacosamida) e de uma formulação farmacêutica, e uso de (r)-n-benzil-2-nboc-amino-3-metoxipropionamida (c-937)
TW200728466A (en) Antibody molecules having specificity for human IL-6
TW200505942A (en) Antibody molecules having specificity for human IL-1β
DE60201829D1 (de) Azaheterocyclylmethyl derivative des 2,3-dihydro-1,4-dioxino(2,3-f)quinolins als antidepressiva
BR0314277A (pt) Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
NO20055208L (no) 4-(2-fenylsulfanyl-fenyl)-piperidinderivater som serotonin-reopptaksinhibitorer
DK1761478T3 (da) En isoleret Atomoxetin urenhed, fremgangsmåde til fremstilling af Atomoxetin urenheder og deres anvendelse som referencestandarder
AR035083A1 (es) Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios
EA200801081A1 (ru) Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
NO20051617L (no) Piperidinderivater av heterocyklusfusjonerte benzodioksaner med antidepressiv aktivitet
AR066760A1 (es) Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos, composiciones farmaceuticas, procesos de obtencion
WO2002088136A3 (en) Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
BR0209343A (pt) Antidepressivos de azaheterociclilmetila derivados de [1,4]-benzodioxanos oxaheterociclo-fundidos; métodos de tratamento usando tais compostos; processo para prepará-los
DK1725526T3 (da) Fremgangsmåde til fremstilling af pyrrolidinoximer
EA200801239A1 (ru) Новые способы получения пиперазинильных и диазепанильных производных бензамина
AR048134A1 (es) La combinacion de un inhibidor de la recaptacion de serotonina y un antagonista del receptor de la histamina 3, el agonista inverso o el agonista parcial
EA200501577A1 (ru) Производные 4-(2-фенилсульфанилфенил)пиперидина в качестве ингибиторов повторного поглощения серотонина
ATE417055T1 (de) Steroid modifizierte solatriosen
HRP20070123A2 (en) Phenyl-piperazine derivatives as serotonin reuptake inhibitors