DK154293C - Analogifremgangsmaade til fremstilling af 2(3h)-indoloner - Google Patents

Analogifremgangsmaade til fremstilling af 2(3h)-indoloner

Info

Publication number
DK154293C
DK154293C DK300181A DK300181A DK154293C DK 154293 C DK154293 C DK 154293C DK 300181 A DK300181 A DK 300181A DK 300181 A DK300181 A DK 300181A DK 154293 C DK154293 C DK 154293C
Authority
DK
Denmark
Prior art keywords
indolons
preparation
group
analogy procedure
indolone
Prior art date
Application number
DK300181A
Other languages
English (en)
Other versions
DK154293B (da
DK300181A (da
Inventor
William Francis Huffman
James William Wilson
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of DK300181A publication Critical patent/DK300181A/da
Publication of DK154293B publication Critical patent/DK154293B/da
Application granted granted Critical
Publication of DK154293C publication Critical patent/DK154293C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK300181A 1980-08-22 1981-07-07 Analogifremgangsmaade til fremstilling af 2(3h)-indoloner DK154293C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/180,551 US4314944A (en) 1980-08-22 1980-08-22 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US18055180 1980-08-22

Publications (3)

Publication Number Publication Date
DK300181A DK300181A (da) 1982-02-23
DK154293B DK154293B (da) 1988-10-31
DK154293C true DK154293C (da) 1989-03-28

Family

ID=22660875

Family Applications (1)

Application Number Title Priority Date Filing Date
DK300181A DK154293C (da) 1980-08-22 1981-07-07 Analogifremgangsmaade til fremstilling af 2(3h)-indoloner

Country Status (11)

Country Link
US (1) US4314944A (da)
EP (1) EP0046666B1 (da)
JP (1) JPS5770866A (da)
AT (1) ATE19395T1 (da)
AU (1) AU542492B2 (da)
CA (1) CA1161047A (da)
DE (1) DE3174461D1 (da)
DK (1) DK154293C (da)
GR (1) GR75312B (da)
IE (1) IE51676B1 (da)
MY (1) MY8700935A (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4588740A (en) * 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
DE3574132D1 (en) * 1984-05-28 1989-12-14 Ciba Geigy Ag Means for the protection of culture plants against the phytotoxic action of chloracetanilide herbicides
US4593106A (en) * 1984-06-04 1986-06-03 Smithkline Beckman Corporation 4-[2-(dialkylamino)ethyl]-7-hydroxyisatins
DE3430310A1 (de) * 1984-08-15 1986-02-27 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0189473B1 (de) * 1984-08-15 1992-05-27 Schering Aktiengesellschaft Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4554287A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
GB9300309D0 (en) * 1993-01-08 1993-03-03 Smithkline Beecham Plc Process
US5611815A (en) * 1994-12-08 1997-03-18 Heartstream, Inc. Defibrillator with training features
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
AR004523A1 (es) 1995-11-06 1998-12-16 American Home Prod 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
FR2752071B1 (fr) 1996-07-30 1998-12-18 Thomson Csf Lecteur pour cartes a puce a interface homme-machine amelioree
US5817690A (en) * 1996-08-27 1998-10-06 American Home Products Corporation 4-aminoethoxy indolone derivatives
ES2179362T3 (es) * 1996-08-27 2003-01-16 Wyeth Corp Derivados de 4-aminoetoxi indolona.
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
TW200811182A (en) * 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH421107A (de) * 1963-06-04 1966-09-30 Sandoz Ag Verfahren zur Herstellung neuer heterocyclischer Verbindungen
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
JPS539227B2 (da) 1973-12-26 1978-04-04
US4053613A (en) * 1975-09-17 1977-10-11 E. R. Squibb & Sons, Inc. 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones
JPS5840539B2 (ja) * 1976-03-31 1983-09-06 大塚製薬株式会社 α−置換アミノアルカノイルオキシインド−ル誘導体
JPS5825673B2 (ja) * 1976-03-31 1983-05-28 大塚製薬株式会社 オキシインド−ル誘導体
JPS5919537B2 (ja) * 1976-08-02 1984-05-07 大塚製薬株式会社 オキシインド−ル誘導体

Also Published As

Publication number Publication date
DK154293B (da) 1988-10-31
DE3174461D1 (en) 1986-05-28
JPS5770866A (en) 1982-05-01
IE51676B1 (en) 1987-02-04
US4314944A (en) 1982-02-09
DK300181A (da) 1982-02-23
IE811922L (en) 1982-02-22
EP0046666A1 (en) 1982-03-03
EP0046666B1 (en) 1986-04-23
CA1161047A (en) 1984-01-24
AU7909481A (en) 1983-07-07
GR75312B (da) 1984-07-13
MY8700935A (en) 1987-12-31
AU542492B2 (en) 1985-02-21
ATE19395T1 (de) 1986-05-15

Similar Documents

Publication Publication Date Title
DK154293C (da) Analogifremgangsmaade til fremstilling af 2(3h)-indoloner
IT7950742A0 (it) Sistema per il controllo automaticodi emodialisi
DK271682A (da) Fremgangsmaade til fremstilling af carboxylsyrederivater
DK247081A (da) Fremgansmaade til fremstilling af derivater af forbindelse ml-236b.
DK373479A (da) Fremgangsmaade til fremstilling af et enzymderivat
DK154568C (da) Fremgangsmaade til fremstilling af et antioxidantholdigt kondensat
IT1099461B (it) Impianto di servocontrollo a pedinamento automatico particolarmente per l'impiego di apparecchiatura da riproduzione
DK151260C (da) Analogifremgangsmaade til fremstilling af spiro-thienohydantoinderivater.
DK460181A (da) Fremgangsmaade til fremstilling af azebicyclooctancar boxylsyrer
DK416479A (da) Fremgangsmaade til fremstilling af cyanoketoner afledt af glycyrrhetinsyre
DK149773C (da) Analogifremgangsmaade til fremstilling af 3-quinolincarboxylsyrederivater
DK125179A (da) Fremgangsmaade til fremstilling af disubstituerede 3-cephem-4-catboxylsyrederivater
NO158871C (no) Analogifremgangsmaate for fremstilling av pyridazinderivater.
DK155914C (da) Fremgangsmaade til stabilisering af 3-formylamino-4-hydroxy-alfa-oen-(1-methyl-2-p-methoxyphenylethyl) aminomethylaabenzylalkohol.1/2fumarat.monohydrat (bd-40a) til brug i et suppositorium
DK96179A (da) Fremgangsmaade til fremstilling af heterocyclylcarbonylderivater af urinstof
GB2014137A (en) Optically-active substituted acetic acid derivatives
DK157673C (da) Analogifremgangsmaade til fremstilling af phenylaliphatiske carboxylsyrederivater
DK34781A (da) Fremgangsmaade til fremstilling af phenylalkansyrederivater
DK20279A (da) Fremgangsmaade til fremstilling af 4-pyridon-3-carboxylsyrederivater
DK331679A (da) Fremgangsmaade til fremstilling af phenylalkansyrederivater
DK257779A (da) Fremgangsmaade til fremstilling af chlor-styryl-cyclopropan-carboxylsyrederivater
BR7901429A (pt) Disposicao de circuito para a eliminacao automatica da distorcao de um sinal
DK340478A (da) Fremgangsmaade til fremstilling af dibenzo (d,g)-(1,3,6)dioxazocinderivater eller syreadditionssalte deraf
DK159850C (da) Analogifremgangsmaade til fremstilling af phenyledddikesyrederivater
DK150879A (da) Fremgangsmaade til fremstilling af oximderivater af 3-azidomethyl-7-aminothiazolylacetamidocephalosporansyre

Legal Events

Date Code Title Description
PBP Patent lapsed