DK154287A - Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne - Google Patents

Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne

Info

Publication number
DK154287A
DK154287A DK154287A DK154287A DK154287A DK 154287 A DK154287 A DK 154287A DK 154287 A DK154287 A DK 154287A DK 154287 A DK154287 A DK 154287A DK 154287 A DK154287 A DK 154287A
Authority
DK
Denmark
Prior art keywords
oxadiazoles
intermediates
procedures
procedure
production
Prior art date
Application number
DK154287A
Other languages
English (en)
Other versions
DK154287D0 (da
Inventor
Raymond Baker
Angus Murray Macleod
Kevin John Merchant
John Saunders
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868607713A external-priority patent/GB8607713D0/en
Priority claimed from GB868630896A external-priority patent/GB8630896D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of DK154287D0 publication Critical patent/DK154287D0/da
Publication of DK154287A publication Critical patent/DK154287A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK154287A 1986-03-27 1987-03-26 Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne DK154287A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868607713A GB8607713D0 (en) 1986-03-27 1986-03-27 Oxadiazoles
GB868630896A GB8630896D0 (en) 1986-12-24 1986-12-24 Oxadiazoles

Publications (2)

Publication Number Publication Date
DK154287D0 DK154287D0 (da) 1987-03-26
DK154287A true DK154287A (da) 1987-09-28

Family

ID=26290549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK154287A DK154287A (da) 1986-03-27 1987-03-26 Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne

Country Status (16)

Country Link
US (1) US5686463A (da)
EP (1) EP0239309B1 (da)
JP (1) JPH0784466B2 (da)
KR (1) KR870008883A (da)
CN (1) CN87102972A (da)
AU (1) AU603564B2 (da)
DE (1) DE3788739T2 (da)
DK (1) DK154287A (da)
ES (1) ES2061489T3 (da)
FI (1) FI871325A (da)
HU (1) HUT51617A (da)
IL (1) IL81930A0 (da)
NO (1) NO169439C (da)
NZ (1) NZ219646A (da)
PT (1) PT84533B (da)
YU (1) YU46688B (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837241A (en) * 1986-09-08 1989-06-06 A/S Ferrosan Lipophillically-substituted piperidine oxadiazolyl compounds and their use in stimulating cognitive functions
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8528633D0 (en) * 1985-11-21 1985-12-24 Beecham Group Plc Compounds
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
AU620783B3 (en) * 1986-06-27 1992-01-09 Beecham Group Plc 1,2,4-oxadiazolyl-azabicyclo compounds
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
US5405853A (en) * 1987-09-10 1995-04-11 Merck Sharpe & Dohme Ltd. Thiadiazoles useful in the treatment of senile dementia
DE3877470T2 (de) * 1987-09-10 1993-06-24 Merck Sharp & Dohme Oxazole und thiazole zur behandlung seniler demenz.
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322034A3 (en) * 1987-12-22 1991-01-02 Merck Sharp & Dohme Ltd. Methyl tetrahydropyridyl oxadiazoles
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
EP0363085A3 (en) * 1988-10-03 1991-03-27 Beecham Group Plc Novel compounds
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
IT1229491B (it) * 1988-12-28 1991-09-03 Roussel Maestretti S P A Ora R Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
US5106853A (en) * 1989-05-15 1992-04-21 Merck Sharp & Dohme, Ltd. Oxadiazole and its salts, their use in treating dementia
GB8911080D0 (en) * 1989-05-15 1989-06-28 Merck Sharp & Dohme Chemical process
US5075317A (en) * 1989-06-21 1991-12-24 Fisons Corporation Spirofurane derivatives
US5177084A (en) * 1989-08-08 1993-01-05 Merck Sharp & Dohme Ltd. Therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes
CA2022886A1 (en) * 1989-08-08 1991-02-09 Raymond Baker Substituted pyridines, their preparation, formulations and use in dementia
GB8918061D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
GB8918060D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
DE69030695T2 (de) * 1989-08-16 1998-01-08 Beecham Group Plc Azabicyclische Verbindungen
ATE136031T1 (de) * 1989-10-07 1996-04-15 Beecham Group Plc Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
EP0456310A3 (en) * 1990-05-09 1992-03-04 Merck Sharp & Dohme Ltd. Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
DK0456519T3 (da) * 1990-05-11 1994-11-07 Sankyo Co Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
CA2050264A1 (en) * 1990-08-30 1992-03-01 Raymond Baker Substituted pyrazine and its salts, compositions containing them and their use in medicine
US5124460A (en) * 1991-05-06 1992-06-23 Merck Sharp & Dohme Ltd. Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5622976A (en) * 1991-12-31 1997-04-22 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5244906A (en) * 1992-01-23 1993-09-14 Dowelanco Insect control with substituted oxadiazole and thiadiazole compounds
TW214545B (da) * 1992-02-17 1993-10-11 Ciba Geigy Ag
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
US5393767A (en) * 1993-08-26 1995-02-28 Dowelanco Insect control with substituted triazole and tetrazole compounds
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
WO1997019669A2 (en) * 1995-11-29 1997-06-05 Eli Lilly And Company Heterocyclic compounds and their use
GB9603755D0 (en) * 1996-02-22 1996-04-24 Pfizer Ltd Therapeutic agents
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
JP2004506686A (ja) * 2000-08-21 2004-03-04 ジョージタウン　ユニバーシティ モノアミン輸送体のモジュレーターとしての２，３−二置換キヌクリジン、及びこれに基づく治療及び診断法
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
CA2517957C (en) * 2003-03-05 2012-01-24 Toray Industries, Inc. Aromatic polymer, film, electrolyte membrane and separator
AU2004282201A1 (en) 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
US8084473B2 (en) * 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
EP2296471A4 (en) 2008-05-15 2012-03-14 Univ Toledo MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS
RU2707067C2 (ru) * 2009-12-04 2019-11-22 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1053085A (da) * 1964-03-26
JPS51143050U (da) * 1975-05-14 1976-11-17
JPS5811948Y2 (ja) * 1982-02-25 1983-03-07 日清紡績株式会社 ブレ−キシユ−引込用スプリング装置
GB8314391D0 (en) * 1983-05-24 1983-06-29 Kefalas As Heterocyclic compounds
JPS6075732U (ja) * 1983-10-31 1985-05-27 シャープ株式会社 ばね掛け装置
JPS6191185A (ja) * 1984-10-11 1986-05-09 Sumitomo Seiyaku Kk 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
DE69030695T2 (de) * 1989-08-16 1998-01-08 Beecham Group Plc Azabicyclische Verbindungen

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837241A (en) * 1986-09-08 1989-06-06 A/S Ferrosan Lipophillically-substituted piperidine oxadiazolyl compounds and their use in stimulating cognitive functions
US4933353A (en) * 1986-09-08 1990-06-12 A/S Ferrosan Lipophilically-substituted piperidine oxadiazolyl compounds and their use in stimulating cognitive functions (II)
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
US5686463A (en) 1997-11-11
EP0239309A3 (en) 1988-11-30
KR870008883A (ko) 1987-10-21
NO169439B (no) 1992-03-16
CN87102972A (zh) 1987-11-18
AU7068687A (en) 1987-10-01
IL81930A0 (en) 1987-10-20
HUT51617A (en) 1990-05-28
PT84533B (pt) 1989-11-10
DK154287D0 (da) 1987-03-26
NO871277L (no) 1987-09-28
NO169439C (no) 1992-06-24
YU53587A (en) 1988-08-31
FI871325A0 (fi) 1987-03-26
EP0239309B1 (en) 1994-01-12
PT84533A (en) 1987-04-01
NZ219646A (en) 1990-10-26
JPH0784466B2 (ja) 1995-09-13
FI871325A (fi) 1987-09-28
DE3788739T2 (de) 1994-07-14
YU46688B (sh) 1994-04-05
ES2061489T3 (es) 1994-12-16
DE3788739D1 (de) 1994-02-24
JPS6317879A (ja) 1988-01-25
EP0239309A2 (en) 1987-09-30
NO871277D0 (no) 1987-03-26
AU603564B2 (en) 1990-11-22

Similar Documents

Publication Publication Date Title
DK154287D0 (da) Substituerede oxadiazol-derivater, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemiddel indeholdende oxadiazolerne
NO871408D0 (no) Forbedringer ved farmasoeytiske akseptable salter.
FI871041A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 3,5-disubstituoitujen pyrokatekolijohdannaisten valmistamiseksi
DK345488D0 (da) Azolylmethyl-cyclopropyl-derivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
NO885106D0 (no) FremgangsmŸte ved fremstilling av cytidin-derivater.
NO894786L (no) Fremgangsmaate for fremstilling av propenonoksimetere.
DK528889D0 (da) Substituerede quinolinderivater og fremgangsmaade til fremstilling deraf, mellemprodukter til anvendelse ved deres fremstilling og farmaceutiske midler indeholdende derivaterne
NO880068D0 (no) Fremgangsmaate ved fremstilling av heteroaryl-3-okso-propannitrilderivater.
DK300688A (da) Heterocycliske hydroxyethylazolderivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
NO880473L (no) Fremgangsmaate til fremstilling av substituerte 3,4-dihydro-2h-benzopyraner og deres anvendelse som legemiddel.
NO803881L (no) Nye derivater av 2-(4-piperidyl)-1-(4-kinolyl)-etanon, samt mellomprodukter for, og fremstilling og bruk av medikamenter
NO882562D0 (no) Nye 2-guanidino-tiazol-forbindelser fremgangsmaate for fremstilling derav og anvendelse derav.
DK656588A (da) Substituerede hydroxylaminer, deres fremstilling og anvendelse som laegemidler, samt ved fremstillingen anvendelige mellemprodukter og fremstilling deraf
DK567188A (da) 2,2-dimethylchromenderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne
DK416888D0 (da) Cephalosporinforbindelser, krystallinske derivater deraf, mellemprodukter til brug ved fremstilling af cephalosporinforbindelser og fremgangsmaader til fremstilling af cephalosporinforbindelser
DK536488D0 (da) Alkadienderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt laegemidler deraf
NO872158L (no) Fremgangsmaate ved fremstilling av nye aromatiske naftylderivater.
NO883986D0 (no) Fremgangsmaate for fremstilling av n-(substituert alkyliden)-1,2,3,4-tetrahydro-9-akridinaminer og anvendelse derav som medikamenter.
DK612886D0 (da) Substituerede ortho-anisamider, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved fremgangsmaaden samt laegemidler indeholdende anisamiderne
DK639888A (da) 3-aminopyrazolin-5-oner, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK439588A (da) Beta-lactamer, fremgangsmaade til deres fremstilling, mellemprodukter til brug derved og farmaceutiske praeparater indeholdende forbindelserne
NO881775D0 (no) Kondenserte heteroalkylen-kinolinaminer, en fremgangsmaate og mellomprodukter for deres fremstilling samt anvendelse av forbindelsene som medikamenter.
DK631386D0 (da) 1-carbacephalosporin-antibiotika, fremgangsmaade til fremstilling deraf samt mellemprodukter til brug ved fremgangsmaaden
NO884600L (no) Fremgangsmaate ved fremstilling av et roerformet legeme.
NO881055D0 (no) Fremgangsmaate ved fremstilling av okso-isoindolinyl-derivater.

Legal Events

Date Code Title Description
PBP Patent lapsed
AHS Application shelved for other reasons than non-payment