ES2061489T3 - Oxadiazoles utiles en el tratamiento de la demencia senil. - Google Patents

Oxadiazoles utiles en el tratamiento de la demencia senil.

Info

Publication number
ES2061489T3
ES2061489T3 ES87302296T ES87302296T ES2061489T3 ES 2061489 T3 ES2061489 T3 ES 2061489T3 ES 87302296 T ES87302296 T ES 87302296T ES 87302296 T ES87302296 T ES 87302296T ES 2061489 T3 ES2061489 T3 ES 2061489T3
Authority
ES
Spain
Prior art keywords
oxadiazoles
useful
treatment
senile dementia
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87302296T
Other languages
English (en)
Inventor
Raymond Baker
Angus Murray Macleod
Kevin John Merchant
John Saunders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868607713A external-priority patent/GB8607713D0/en
Priority claimed from GB868630896A external-priority patent/GB8630896D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2061489T3 publication Critical patent/ES2061489T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION TRATA DE UNA CLASE DE NUEVOS OXADIAZOLES, SUSTITUIDOS EN UNO DE LOS ATOMOS DE CARBONO DEL ANILLO CON UN ANILLO AZACICLICO O AZABICICLICO NO-AROMATICO Y SUSTITUIDO SOBRE EL OTRO ATOMO DE CARBONO DEL ANILLO CON UN SUSTITUYENTE DE BAJA LIOFILICIDAD.LOS COMPUESTOS SON POTENTES AGONISTAS MUSCARINICOS Y TIENEN UNA BUENA PENETRABILIDAD EN EL SNC, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS Y MENTALES.
ES87302296T 1986-03-27 1987-03-18 Oxadiazoles utiles en el tratamiento de la demencia senil. Expired - Lifetime ES2061489T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868607713A GB8607713D0 (en) 1986-03-27 1986-03-27 Oxadiazoles
GB868630896A GB8630896D0 (en) 1986-12-24 1986-12-24 Oxadiazoles

Publications (1)

Publication Number Publication Date
ES2061489T3 true ES2061489T3 (es) 1994-12-16

Family

ID=26290549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87302296T Expired - Lifetime ES2061489T3 (es) 1986-03-27 1987-03-18 Oxadiazoles utiles en el tratamiento de la demencia senil.

Country Status (16)

Country Link
US (1) US5686463A (es)
EP (1) EP0239309B1 (es)
JP (1) JPH0784466B2 (es)
KR (1) KR870008883A (es)
CN (1) CN87102972A (es)
AU (1) AU603564B2 (es)
DE (1) DE3788739T2 (es)
DK (1) DK154287A (es)
ES (1) ES2061489T3 (es)
FI (1) FI871325A (es)
HU (1) HUT51617A (es)
IL (1) IL81930A0 (es)
NO (1) NO169439C (es)
NZ (1) NZ219646A (es)
PT (1) PT84533B (es)
YU (1) YU46688B (es)

Families Citing this family (76)

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DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
AU620783B3 (en) * 1986-06-27 1992-01-09 Beecham Group Plc 1,2,4-oxadiazolyl-azabicyclo compounds
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
AU614513B2 (en) * 1987-04-15 1991-09-05 Beecham Group Plc 1-azabicyclic compounds
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
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US5405853A (en) * 1987-09-10 1995-04-11 Merck Sharpe & Dohme Ltd. Thiadiazoles useful in the treatment of senile dementia
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IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322034A3 (en) * 1987-12-22 1991-01-02 Merck Sharp & Dohme Ltd. Methyl tetrahydropyridyl oxadiazoles
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
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NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
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GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
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GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
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US5075317A (en) * 1989-06-21 1991-12-24 Fisons Corporation Spirofurane derivatives
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
US5177084A (en) * 1989-08-08 1993-01-05 Merck Sharp & Dohme Ltd. Therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes
GB8918061D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
GB8918060D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
EP0413545B1 (en) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclic compounds
ATE136031T1 (de) * 1989-10-07 1996-04-15 Beecham Group Plc Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
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EP0456310A3 (en) * 1990-05-09 1992-03-04 Merck Sharp & Dohme Ltd. Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
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USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
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CA2050264A1 (en) * 1990-08-30 1992-03-01 Raymond Baker Substituted pyrazine and its salts, compositions containing them and their use in medicine
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GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
EP0413545B1 (en) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclic compounds

Also Published As

Publication number Publication date
YU46688B (sh) 1994-04-05
DE3788739D1 (de) 1994-02-24
NO871277D0 (no) 1987-03-26
EP0239309B1 (en) 1994-01-12
FI871325A0 (fi) 1987-03-26
DK154287A (da) 1987-09-28
EP0239309A2 (en) 1987-09-30
NO169439B (no) 1992-03-16
HUT51617A (en) 1990-05-28
CN87102972A (zh) 1987-11-18
PT84533B (pt) 1989-11-10
JPH0784466B2 (ja) 1995-09-13
US5686463A (en) 1997-11-11
IL81930A0 (en) 1987-10-20
AU603564B2 (en) 1990-11-22
NO169439C (no) 1992-06-24
EP0239309A3 (en) 1988-11-30
FI871325A (fi) 1987-09-28
AU7068687A (en) 1987-10-01
YU53587A (en) 1988-08-31
NO871277L (no) 1987-09-28
PT84533A (en) 1987-04-01
NZ219646A (en) 1990-10-26
DE3788739T2 (de) 1994-07-14
KR870008883A (ko) 1987-10-21
DK154287D0 (da) 1987-03-26
JPS6317879A (ja) 1988-01-25

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