DK154264C - Fremgangsmaade til fremstilling af lipid-vesikler - Google Patents

Fremgangsmaade til fremstilling af lipid-vesikler

Info

Publication number
DK154264C
DK154264C DK472980A DK472980A DK154264C DK 154264 C DK154264 C DK 154264C DK 472980 A DK472980 A DK 472980A DK 472980 A DK472980 A DK 472980A DK 154264 C DK154264 C DK 154264C
Authority
DK
Denmark
Prior art keywords
cholesten
yloxy
thio
hexyl
vesicles
Prior art date
Application number
DK472980A
Other languages
Danish (da)
English (en)
Other versions
DK154264B (da
DK472980A (da
Inventor
Marcia R Mauk
John D Baldeschwieler
Ronald C Gamble
Tsung-Ying Shen
Mitree M Ponpipom
Original Assignee
Merck & Co Inc
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, California Inst Of Techn filed Critical Merck & Co Inc
Publication of DK472980A publication Critical patent/DK472980A/da
Publication of DK154264B publication Critical patent/DK154264B/da
Application granted granted Critical
Publication of DK154264C publication Critical patent/DK154264C/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK472980A 1979-11-08 1980-11-07 Fremgangsmaade til fremstilling af lipid-vesikler DK154264C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/092,342 US4310505A (en) 1979-11-08 1979-11-08 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US9234279 1979-11-08

Publications (3)

Publication Number Publication Date
DK472980A DK472980A (da) 1981-05-09
DK154264B DK154264B (da) 1988-10-31
DK154264C true DK154264C (da) 1989-03-28

Family

ID=22232767

Family Applications (1)

Application Number Title Priority Date Filing Date
DK472980A DK154264C (da) 1979-11-08 1980-11-07 Fremgangsmaade til fremstilling af lipid-vesikler

Country Status (12)

Country Link
US (1) US4310505A (fr)
EP (1) EP0028917B1 (fr)
JP (1) JPS5675439A (fr)
AT (1) ATE7656T1 (fr)
AU (1) AU533213B2 (fr)
DE (1) DE3068062D1 (fr)
DK (1) DK154264C (fr)
ES (1) ES8203222A1 (fr)
GR (1) GR71720B (fr)
IE (1) IE50369B1 (fr)
NZ (1) NZ195377A (fr)
PT (1) PT72040B (fr)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
JPS5874619A (ja) * 1981-10-29 1983-05-06 Nippon Shinyaku Co Ltd リポソ−ム及びその製法
US5441745A (en) * 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US5435989A (en) * 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
JPS58201711A (ja) * 1982-05-19 1983-11-24 Eisai Co Ltd ユビデカレノン含有リポソ−ム被覆体
US4865835A (en) * 1982-06-02 1989-09-12 Begent Richard H J Diagnosis and treatment of tumors
US4460560A (en) * 1982-06-18 1984-07-17 University Of Southern California Drug delivery by polymeric carriers
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4571332A (en) * 1982-09-19 1986-02-18 Litton Bionetics, Inc. 125 I and 131 I labeled phospholipids
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4574079A (en) * 1983-05-27 1986-03-04 Gavras Haralambos P Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3336583A1 (de) * 1983-09-26 1985-04-25 Udo Dr. 8400 Regensburg Ehrenfeld Erzeugnis zur diagnose und therapie von malignen tumoren
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US4665897A (en) * 1984-05-25 1987-05-19 Lemelson Jerome H Composition and method for detecting and treating cancer
US4674480A (en) * 1984-05-25 1987-06-23 Lemelson Jerome H Drug compositions and methods of applying same
GB8422876D0 (en) * 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
AU591466B2 (en) * 1984-10-22 1989-12-07 Vestar, Inc. Method of delivering micellular particles encapsulating imaging and chemotherapeutic agents to tumors in a body
CA1298548C (fr) * 1984-10-22 1992-04-07 Cary Arnet Presant Methode de transport d'agents chimiotherapeutiques ou de visualisation sous forme de particules micellulaires vers des tissus tumoraux dans un organisme
US5019369A (en) * 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
CA1267840A (fr) * 1984-11-23 1990-04-17 Cary Arnet Presant Methode de ciblage des tumeurs chez les humains
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification
US4740375A (en) * 1985-02-25 1988-04-26 Technology Unlimited, Inc. Gelcores
US4752572A (en) * 1985-08-30 1988-06-21 Eastman Kodak Company Lipid vesicles containing labeled species and their analytical uses
US5622713A (en) * 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
JPS62270531A (ja) * 1985-11-01 1987-11-24 サントル ナシヨナ−ル ド ラ ルシエルシユ シヤンテイフイ−ク(セ−・エン・エル・エス) 生体内でのイメ−ジング及び治療用の新規エアロゾル組成物
US4812314A (en) * 1986-02-24 1989-03-14 Yissum Research & Dev. Co. Of The Hebrew Univ. Of Jerusalem And Hadassah Medical Organization Lipid replacement therapy
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US5043107A (en) * 1986-08-21 1991-08-27 Vestar Research, Inc. Preparation small unilamellar vesicles including polyene antifungal antibiotics
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
AU598958B2 (en) 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US5071598A (en) * 1987-12-03 1991-12-10 California Institute Of Technology Cryoprotective reagent
WO1989005151A1 (fr) 1987-12-04 1989-06-15 The Liposome Company, Inc. Liposomes a degre de stabilite eleve et procede de preparation et d'utilisation de tels liposomes
CA1330199C (fr) * 1987-12-22 1994-06-14 Thomas D. Madden Vesiculation spontanee de liposomes multilamellaires
US5169636A (en) * 1988-03-17 1992-12-08 Nippon Fine Chemical Co., Ltd. Liposomes
NO882653D0 (no) * 1988-06-15 1988-06-15 Apothekernes Lab Doseringsform.
US4931361A (en) * 1988-11-18 1990-06-05 California Institute Of Technology Cryoprotective reagents in freeze-drying membranes
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
FR2645741B1 (fr) * 1989-03-20 1995-06-23 Dior Christian Parfums Procede pour fixer un produit sur la membrane d'un keratinocyte au moyen d'une liaison ligand-recepteur, procede de preparation d'un tel produit, produit obtenu, composition cosmetique ou pharmaceutique le contenant et son procede de preparation
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5325860A (en) * 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
WO1994002068A1 (fr) * 1992-07-21 1994-02-03 The General Hospital Corporation Systeme d'administration d'un medicament aux tissus lyphatiques
US5514784A (en) * 1993-03-19 1996-05-07 Wong; Chi-Huey Thio linked glycosyl compounds
EP0636363B1 (fr) * 1993-07-27 2001-05-23 Terumo Kabushiki Kaisha Système pour la délivrance d'un médicament
NZ275054A (en) * 1993-11-08 1997-04-24 Peptide Delivery Systems Pty L Diagnosing atherosclerosis or coronary artery disease using labelled composition which mimics essential features of an exogenous lipoprotein
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
JP2787279B2 (ja) * 1994-05-17 1998-08-13 雪印乳業株式会社 糖リン脂質及びその調製法
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6235308B1 (en) 1994-06-10 2001-05-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating hypertension
US5622715A (en) * 1994-06-10 1997-04-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of improving renal function
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5660855A (en) * 1995-02-10 1997-08-26 California Institute Of Technology Lipid constructs for targeting to vascular smooth muscle tissue
AU4923696A (en) * 1995-02-10 1996-08-27 Nexstar Pharmaceuticals, Inc. Lipid constructs for cytoplasmic delivery of agents
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US20040208922A1 (en) * 1995-06-07 2004-10-21 The Regents Of The University Of California Method for loading lipid like vesicles with drugs or other chemicals
US5704196A (en) * 1995-09-21 1998-01-06 Douglas Machine Limited Liability Company High speed blank set-up apparatus and methods
WO1997040679A1 (fr) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Procedes d'apport de composes dans une cellule
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
ES2189974T3 (es) * 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador.
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
AUPP032097A0 (en) * 1997-11-11 1997-12-04 Peptide Delivery Systems Pty Ltd Improved labelled diagnostic compositions and methods of their use
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU5905400A (en) 1999-07-14 2001-02-05 Board Of Regents, The University Of Texas System Methods and compositions for delivery and retention of active agents to lymph nodes
AU2001236798B2 (en) 2000-02-08 2004-11-04 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
JP2004528321A (ja) 2001-04-04 2004-09-16 ノルディック ワクチン テクノロジー アクティーゼルスカブ ステロールおよびサポニンを含むポリヌクレオチド結合複合体
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
AU2003241598B2 (en) * 2002-07-02 2009-11-05 Nanotx Corp. Radiolabeled compounds and liposomes and their methods of making and using the same
US20060147509A1 (en) * 2002-10-02 2006-07-06 Kirkby Nikolai S Composition for vaccination
CA2534426A1 (fr) * 2003-08-08 2005-02-17 Barnes-Jewish Hospital Particules d'emulsion destinees a l'imagerie et a la therapie et procedes d'utilisation de celles-ci
US20080241262A1 (en) * 2004-03-29 2008-10-02 The University Of Houston System Nanoshells and Discrete Polymer-Coated Nanoshells, Methods For Making and Using Same
CA2618807C (fr) * 2005-08-12 2015-01-06 University Health Network Procedes et dispositifs permettant le ciblage lymphatique
WO2007087418A2 (fr) * 2006-01-24 2007-08-02 Imarx Therapeutics, Inc. Composition et procede destines au blocage neuromusculaire
WO2007115134A2 (fr) 2006-03-29 2007-10-11 Wayne State University Nanoparticules de liposome et autres formulations de fenrétinide utiles en thérapie et pour l'apport de médicament
US20070258908A1 (en) * 2006-04-27 2007-11-08 Lanza Gregory M Detection and imaging of target tissue
WO2007127439A2 (fr) 2006-04-28 2007-11-08 Children's Hospital Medical Center Propriétés fusiogènes de la saposine c et de protéines et peptides apparentés pour une application dans des systèmes de délivrance transmembranaire de médicaments
WO2008137114A1 (fr) * 2007-05-04 2008-11-13 University Of Hawai'i Procédés et compositions pour une administration ciblée de vecteurs thérapeutiques de gène
WO2012119095A1 (fr) 2011-03-02 2012-09-07 Board Of Regents, The University Of Texas System Thérapies utilisant le fus1/tusc2
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
CN110464709A (zh) 2012-08-10 2019-11-19 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
US10226744B2 (en) 2012-10-19 2019-03-12 Danisco Us Inc Stabilization of biomimetic membranes
EP2727929A1 (fr) * 2012-10-30 2014-05-07 Wittycell Procédé de préparation de composés de céramides avec un radical alpha galactosyle
US10736880B2 (en) 2015-12-18 2020-08-11 The Board Of Regents Of The University Of Texas Systems Therapeutics for preterm labor management
CN110072540B (zh) 2016-10-12 2023-06-02 得克萨斯州大学系统董事会 用于tusc2免疫治疗的方法和组合物
CN111511484A (zh) 2017-11-04 2020-08-07 索纳纳米技术公司 金属纳米颗粒及制备所述金属纳米颗粒的方法
ES2895180T3 (es) 2018-03-23 2022-02-17 Bexion Pharmaceuticals Inc Composiciones farmacéuticas de saposina C y su uso en el tratamiento de cáncer
US20210395721A1 (en) 2018-10-24 2021-12-23 Codiak Biosciences, Inc. Methods to improve potency of electroporation
CA3117866A1 (fr) 2018-11-09 2020-05-14 Translate Bio, Inc. Composes lipidiques comportant plusieurs groupes peg
US20220071905A1 (en) 2018-11-09 2022-03-10 Translate Bio, Inc. Peg lipidoid compounds
JP2022519718A (ja) 2019-02-08 2022-03-24 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 加齢および加齢性臓器不全に関連する疾患の処置のためのテロメラーゼ含有エキソソーム
CA3175301A1 (fr) 2020-04-20 2021-10-28 Hugh D.C. Smyth Compositions de poudre seche biologiquement actives et leur procede de fabrication et d'utilisation
US20230226219A1 (en) 2020-05-14 2023-07-20 Translate Bio, Inc. Peg lipidoid compounds
CN113730603B (zh) * 2020-05-27 2023-01-24 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治与甲状腺切除相关的疾病的药物中的应用
CN114053436A (zh) * 2020-07-29 2022-02-18 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治乳腺癌的药物中的应用
WO2022040435A1 (fr) 2020-08-19 2022-02-24 The Board Of Regents Of The University Of Texas System Nanomédicaments pour l'administration ciblée de médicaments et leur utilisation
WO2023225160A1 (fr) 2022-05-18 2023-11-23 The Children's Hospital Of Philadelphia Compositions et procédés de régulation de l'épissage alternatif inductible de l'expression génique

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663685A (en) * 1968-04-01 1972-05-16 Minnesota Mining & Mfg Biodegradable radioactive particles
US3522346A (en) * 1968-05-31 1970-07-28 Research Corp Nonthrombogenic microcapsules
US3663687A (en) * 1968-06-26 1972-05-16 Minnesota Mining & Mfg Biodegradable parenteral microspherules
US3683066A (en) * 1969-01-14 1972-08-08 Ivan Ascanio Technetium 99m colloidal composition
US3937668A (en) * 1970-07-15 1976-02-10 Ilse Zolle Method for incorporating substances into protein microspheres
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
US3932657A (en) * 1973-11-12 1976-01-13 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome encapsulation of chelating agents
CH588887A5 (fr) * 1974-07-19 1977-06-15 Battelle Memorial Institute
SE7412164L (sv) * 1974-09-27 1976-03-29 Pharmacia Ab Medel for intravaskuler administrering
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US3992513A (en) * 1975-01-07 1976-11-16 Atomic Energy Of Canada Limited Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs
DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith

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IE50369B1 (en) 1986-04-02
DE3068062D1 (en) 1984-07-05
ES496666A0 (es) 1982-04-01
GR71720B (fr) 1983-06-21
JPS647966B2 (fr) 1989-02-10
PT72040A (en) 1980-12-01
NZ195377A (en) 1984-07-06
EP0028917A3 (en) 1981-07-15
AU533213B2 (en) 1983-11-10
AU6420380A (en) 1981-05-14
ES8203222A1 (es) 1982-04-01
IE802286L (en) 1981-05-08
DK154264B (da) 1988-10-31
JPS5675439A (en) 1981-06-22
US4310505A (en) 1982-01-12
EP0028917A2 (fr) 1981-05-20
DK472980A (da) 1981-05-09
EP0028917B1 (fr) 1984-05-30
ATE7656T1 (de) 1984-06-15
PT72040B (en) 1982-09-02

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