DK154082C - METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS - Google Patents

METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS

Info

Publication number
DK154082C
DK154082C DK428678A DK428678A DK154082C DK 154082 C DK154082 C DK 154082C DK 428678 A DK428678 A DK 428678A DK 428678 A DK428678 A DK 428678A DK 154082 C DK154082 C DK 154082C
Authority
DK
Denmark
Prior art keywords
homopiperazin
piperazin
dimethoxy
analogue
amino
Prior art date
Application number
DK428678A
Other languages
Danish (da)
Other versions
DK428678A (en
DK154082B (en
Inventor
Simon Fraser Campbell
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to US05/952,317 priority Critical patent/US4188390A/en
Publication of DK428678A publication Critical patent/DK428678A/en
Publication of DK154082B publication Critical patent/DK154082B/en
Application granted granted Critical
Publication of DK154082C publication Critical patent/DK154082C/en
Priority to BG096072A priority patent/BG60337B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK428678A 1977-11-05 1978-09-27 METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS DK154082C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US05/952,317 US4188390A (en) 1977-11-05 1978-10-18 Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
BG096072A BG60337B2 (en) 1977-11-05 1992-03-16 4-amino-2-(4-)1,4-benzodioxan-2-carbonyl(piperazine-1-il or homopiperazine-1-il)quinazolines with antihypertension effect

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05
GB4612877 1977-11-05

Publications (3)

Publication Number Publication Date
DK428678A DK428678A (en) 1979-05-06
DK154082B DK154082B (en) 1988-10-10
DK154082C true DK154082C (en) 1989-02-27

Family

ID=10439957

Family Applications (1)

Application Number Title Priority Date Filing Date
DK428678A DK154082C (en) 1977-11-05 1978-09-27 METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS

Country Status (36)

Country Link
JP (1) JPS5498792A (en)
AR (2) AR219562A1 (en)
AT (1) AT365186B (en)
AU (1) AU509329B2 (en)
BE (1) BE871771A (en)
CA (1) CA1088059A (en)
CH (1) CH643255A5 (en)
CS (2) CS207671B2 (en)
DD (1) DD139850A5 (en)
DE (1) DE2847623C2 (en)
DK (1) DK154082C (en)
EG (1) EG13594A (en)
ES (2) ES474805A1 (en)
FI (1) FI64366C (en)
FR (1) FR2407929A1 (en)
GR (1) GR81514B (en)
HK (1) HK94284A (en)
HU (1) HU176306B (en)
IE (1) IE47888B1 (en)
IL (1) IL55857A (en)
IN (1) IN148828B (en)
IT (1) IT1100919B (en)
KE (1) KE3350A (en)
LU (2) LU80470A1 (en)
MY (1) MY8500286A (en)
NL (2) NL174549C (en)
NO (1) NO150158C (en)
NZ (1) NZ188813A (en)
PH (1) PH13966A (en)
PL (2) PL119586B1 (en)
PT (1) PT68735A (en)
SE (1) SE437518B (en)
SU (1) SU816403A3 (en)
UA (1) UA8324A1 (en)
YU (2) YU40204B (en)
ZA (1) ZA786184B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002644A1 (en) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
WO1985004658A1 (en) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepine derivatives and their preparation
WO1985002617A1 (en) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
ATE353892T1 (en) * 1996-12-20 2007-03-15 Heumann Pharma Gmbh & Co NEW POLYMORPHOUS FORM OF DOXAZOSINE MESYLATE (FORM III)
EP0849265A1 (en) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Novel polymorphic form of doxazosin mesylate (form II)
EP0849264A1 (en) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Novel polymorphic form of doxazosin mesylate (form I)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (en) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
GR81514B (en) 1984-12-11
FI64366B (en) 1983-07-29
FR2407929A1 (en) 1979-06-01
UA8324A1 (en) 1996-03-29
HU176306B (en) 1981-01-28
DD139850A5 (en) 1980-01-23
YU255378A (en) 1983-06-30
LU80470A1 (en) 1980-06-05
JPS5625233B2 (en) 1981-06-11
AT365186B (en) 1981-12-28
DK428678A (en) 1979-05-06
IL55857A (en) 1982-07-30
AU4132278A (en) 1979-05-17
PL119419B1 (en) 1981-12-31
IL55857A0 (en) 1979-01-31
CS207671B2 (en) 1981-08-31
PH13966A (en) 1980-11-12
SE437518B (en) 1985-03-04
PT68735A (en) 1978-12-01
YU38683A (en) 1983-06-30
HK94284A (en) 1984-12-07
NL174549B (en) 1984-02-01
NZ188813A (en) 1980-10-08
FI64366C (en) 1983-11-10
ZA786184B (en) 1979-10-31
NL930062I1 (en) 1993-09-01
FR2407929B1 (en) 1981-02-27
NL930062I2 (en) 1993-11-16
JPS5498792A (en) 1979-08-03
SE7811382L (en) 1979-05-06
ES8308559A1 (en) 1980-07-16
ES480121A0 (en) 1980-07-16
AR219562A1 (en) 1980-08-29
NL174549C (en) 1984-07-02
NO150158B (en) 1984-05-21
IT7829434A0 (en) 1978-11-03
MY8500286A (en) 1985-12-31
FI783347A (en) 1979-05-06
PL210681A1 (en) 1979-11-05
IN148828B (en) 1981-06-27
LU88331I2 (en) 1994-05-04
ES474805A1 (en) 1980-01-16
NO783705L (en) 1979-05-08
IT1100919B (en) 1985-09-28
YU40204B (en) 1985-08-31
SU816403A3 (en) 1981-03-23
IE47888B1 (en) 1984-07-11
EG13594A (en) 1982-03-31
ATA784378A (en) 1981-05-15
DE2847623C2 (en) 1983-06-01
AU509329B2 (en) 1980-05-08
NO150158C (en) 1984-08-29
CH643255A5 (en) 1984-05-30
CA1088059A (en) 1980-10-21
NL7810909A (en) 1979-05-08
BE871771A (en) 1979-05-03
DK154082B (en) 1988-10-10
YU40419B (en) 1985-12-31
CS354491A3 (en) 1992-06-17
KE3350A (en) 1983-12-16
AR223015A1 (en) 1981-07-15
PL119586B1 (en) 1982-01-30
DE2847623A1 (en) 1979-05-23
IE782179L (en) 1979-05-05

Similar Documents

Publication Publication Date Title
DK159316C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 4-AMINO-6,7-DIMETHOXYQUINAZOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS
DK152430C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF HETEROCYCLIC SUBSTITUTED 4-AMINO-6,7-DIMETHOXY-2-PIPERAZINOQUINAZOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS
DK149895C (en) PROCEDURE FOR THE PREPARATION OF ALFA-AMINOACYLPROLYL-NG-CARBOXY ARGINALDEHYDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK337383D0 (en) PROCEDURE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXYQUINOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK149022C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF AMINE DERIVATIVES OF DI-O- (N-ALKYL OR ALKENYL) -GYCEROLES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK149449C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK151331C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 5-PYRIDINYL-2 (1H) -PYRIDINON COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS
DK151623C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N-SUBSTITUTED MORANOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK145260C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-ACYLAMINO-PHENYL-ETHANOLAMINES OR ACID ADDITION SALTS
DK160045C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-OXO-4H-PYRIDOOE1,2-AAAPYRIMIDINES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS OR QUATERNARY AMMONIUM SALTS THEREOF
DK154950C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 1- (BENZAZOLYLALKYL) -PIPERIDE INGREDIENTS OR THE PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS
DK392578A (en) PROCEDURE FOR THE PREPARATION OF 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK154082C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS
DK140695B (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF 2,4-DIAMO-6,7-DIMETHOXYQUINAZOLINE DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF
DK149841C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ALFA-FLUOR-METHYL-ALFA AMINOALCANIC ACIDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK149077C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ENCEPHALIN ANALOGUE PENTAPEPTIDAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK15282A (en) PROCEDURE FOR THE PREPARATION OF (+) - ENANTIOMERS OR (+) (-) - RACEMIC 4A, 9B-TRANS-HEXAHYDRO-1H-PYRIDOINDOL DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK152208C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-PHENYLAMINO-PHENYLEDIC ACETIC ACID AMOIDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK152427C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-THIOMETHYLPYRIDINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK146540C (en) PROCEDURE FOR THE PREPARATION OF LEUROSIN TYPE ALKALOIDS OR THEIR ACID ADDITION SALTS
DK157021C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2,3-POLYMETHYLENE-4-OXO-4H-PYRIDO- OR -AZEPINOOE1,2-AAAPYRIMIDINES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS OR QUATERA SALTS
DK152211C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N-PHENYL-N- (4-PIPERIDINYL) -AMIDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK317678A (en) PROCEDURE FOR THE PREPARATION OF 3- (1-PYRAZOLYL) -PYRIDAZINDF ERIVATES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS THEREOF
DK160874C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ERGOL-8-ONE OR ERGOLIN COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK148683C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF PYRIDAZINYL HYDRAZINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.