FR2407929A1 - NEW DERIVATIVES OF 4-AMINO-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents
NEW DERIVATIVES OF 4-AMINO-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEMInfo
- Publication number
- FR2407929A1 FR2407929A1 FR7831126A FR7831126A FR2407929A1 FR 2407929 A1 FR2407929 A1 FR 2407929A1 FR 7831126 A FR7831126 A FR 7831126A FR 7831126 A FR7831126 A FR 7831126A FR 2407929 A1 FR2407929 A1 FR 2407929A1
- Authority
- FR
- France
- Prior art keywords
- radical
- homopiperazin
- quinazoline
- piperazin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to novel derivatives of 4-amino-3-(piperazin-1-yl or homopiperazin-1-yl)quinazoline, which can be used as regulators of the cardiovascular system, and are especially suitable for treating high blood pressure. The compounds have the formula I in which (R)n represents a 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy) radical; m = 1 or 2, X represents the radical -CHR<1>- or -CH2CH2-; each of the radicals R<1>, which may be identical or different to the others, represents a hydrogen atom or a lower alkyl radical; and R<2> and R<3>, which may be identical or different, each represent a hydrogen atom, a lower alkyl radical, lower alkoxy radical, a halogen atom, a lower alkanoyl radical, lower alkoxy carbonyl radical or a radical of the formula -CONR<4>R<5> or -SO2NR<4>R<5>, in which R<4> and R <5>, which may be identical or different, each represent a hydrogen atom or a lower alkyl radical; the compounds may also be present in the form of their pharmaceutically acceptable acid addition salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4612877 | 1977-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2407929A1 true FR2407929A1 (en) | 1979-06-01 |
FR2407929B1 FR2407929B1 (en) | 1981-02-27 |
Family
ID=10439957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7831126A Granted FR2407929A1 (en) | 1977-11-05 | 1978-11-03 | NEW DERIVATIVES OF 4-AMINO-2- (PIPERAZIN-1-YL OR HOMOPIPERAZIN-1-YL) -QUINAZOLINE, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
Country Status (36)
Country | Link |
---|---|
JP (1) | JPS5498792A (en) |
AR (2) | AR219562A1 (en) |
AT (1) | AT365186B (en) |
AU (1) | AU509329B2 (en) |
BE (1) | BE871771A (en) |
CA (1) | CA1088059A (en) |
CH (1) | CH643255A5 (en) |
CS (2) | CS207671B2 (en) |
DD (1) | DD139850A5 (en) |
DE (1) | DE2847623C2 (en) |
DK (1) | DK154082C (en) |
EG (1) | EG13594A (en) |
ES (2) | ES474805A1 (en) |
FI (1) | FI64366C (en) |
FR (1) | FR2407929A1 (en) |
GR (1) | GR81514B (en) |
HK (1) | HK94284A (en) |
HU (1) | HU176306B (en) |
IE (1) | IE47888B1 (en) |
IL (1) | IL55857A (en) |
IN (1) | IN148828B (en) |
IT (1) | IT1100919B (en) |
KE (1) | KE3350A (en) |
LU (2) | LU80470A1 (en) |
MY (1) | MY8500286A (en) |
NL (2) | NL174549C (en) |
NO (1) | NO150158C (en) |
NZ (1) | NZ188813A (en) |
PH (1) | PH13966A (en) |
PL (2) | PL119586B1 (en) |
PT (1) | PT68735A (en) |
SE (1) | SE437518B (en) |
SU (1) | SU816403A3 (en) |
UA (1) | UA8324A1 (en) |
YU (2) | YU40204B (en) |
ZA (1) | ZA786184B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1403263A1 (en) * | 2002-09-27 | 2004-03-31 | Council of Scientific and Industrial Research | Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002644A1 (en) * | 1984-11-01 | 1986-05-09 | Takeda Chemical Industries, Ltd. | 1,5-benzoxathiepin derivatives and process for their preparation |
WO1985004658A1 (en) * | 1984-04-04 | 1985-10-24 | Takeda Chemical Industries, Ltd. | 1,5-benzoxathiepine derivatives and their preparation |
WO1985002617A1 (en) * | 1983-12-14 | 1985-06-20 | Takeda Chemical Industries. Ltd. | 1,5-benzoxathiepin derivatives and process for their preparation |
ATE353892T1 (en) * | 1996-12-20 | 2007-03-15 | Heumann Pharma Gmbh & Co | NEW POLYMORPHOUS FORM OF DOXAZOSINE MESYLATE (FORM III) |
EP0849265A1 (en) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Novel polymorphic form of doxazosin mesylate (form II) |
EP0849264A1 (en) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Novel polymorphic form of doxazosin mesylate (form I) |
TW448155B (en) * | 1999-03-29 | 2001-08-01 | Dev Center Biotechnology | Method for producing amide compounds and quinazolin derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3663706A (en) * | 1969-09-29 | 1972-05-16 | Pfizer | Use of 2,4-diaminoquinazolines as hypotensive agents |
US3669968A (en) * | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
-
1978
- 1978-09-27 DK DK428678A patent/DK154082C/en active
- 1978-10-03 IN IN712/DEL/78A patent/IN148828B/en unknown
- 1978-10-24 PH PH21726A patent/PH13966A/en unknown
- 1978-10-24 CA CA314,027A patent/CA1088059A/en not_active Expired
- 1978-10-31 UA UA2679598A patent/UA8324A1/en unknown
- 1978-10-31 SU SU782679598A patent/SU816403A3/en active
- 1978-11-02 NL NLAANVRAGE7810909,A patent/NL174549C/en not_active IP Right Cessation
- 1978-11-02 HU HU78PI648A patent/HU176306B/en unknown
- 1978-11-02 NZ NZ188813A patent/NZ188813A/en unknown
- 1978-11-02 PT PT68735A patent/PT68735A/en unknown
- 1978-11-02 ZA ZA00786184A patent/ZA786184B/en unknown
- 1978-11-02 DE DE2847623A patent/DE2847623C2/en not_active Expired
- 1978-11-02 IL IL55857A patent/IL55857A/en unknown
- 1978-11-02 JP JP13569578A patent/JPS5498792A/en active Granted
- 1978-11-02 YU YU2553/78A patent/YU40204B/en unknown
- 1978-11-02 CH CH1132178A patent/CH643255A5/en not_active IP Right Cessation
- 1978-11-02 FI FI783347A patent/FI64366C/en not_active IP Right Cessation
- 1978-11-02 AT AT0784378A patent/AT365186B/en not_active IP Right Cessation
- 1978-11-02 CS CS787166A patent/CS207671B2/en unknown
- 1978-11-02 AR AR274321A patent/AR219562A1/en active
- 1978-11-02 SE SE7811382A patent/SE437518B/en not_active IP Right Cessation
- 1978-11-02 GR GR57562A patent/GR81514B/el unknown
- 1978-11-03 PL PL1978210681A patent/PL119586B1/en unknown
- 1978-11-03 PL PL1978216980A patent/PL119419B1/en unknown
- 1978-11-03 IT IT29434/78A patent/IT1100919B/en active Protection Beyond IP Right Term
- 1978-11-03 AU AU41322/78A patent/AU509329B2/en not_active Expired
- 1978-11-03 DD DD78208868A patent/DD139850A5/en unknown
- 1978-11-03 BE BE191544A patent/BE871771A/en not_active IP Right Cessation
- 1978-11-03 IE IE2179/78A patent/IE47888B1/en active Protection Beyond IP Right Term
- 1978-11-03 LU LU80470A patent/LU80470A1/en unknown
- 1978-11-03 ES ES474805A patent/ES474805A1/en not_active Expired
- 1978-11-03 FR FR7831126A patent/FR2407929A1/en active Granted
- 1978-11-03 NO NO783705A patent/NO150158C/en unknown
- 1978-11-04 EG EG641/78A patent/EG13594A/en active
-
1979
- 1979-04-30 ES ES480121A patent/ES480121A0/en active Granted
- 1979-10-18 AR AR278545A patent/AR223015A1/en active
-
1983
- 1983-02-17 YU YU386/83A patent/YU40419B/en unknown
- 1983-11-21 KE KE3350A patent/KE3350A/en unknown
-
1984
- 1984-11-29 HK HK942/84A patent/HK94284A/en not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY286/85A patent/MY8500286A/en unknown
-
1991
- 1991-11-22 CS CS913544A patent/CS354491A3/en unknown
-
1993
- 1993-06-11 NL NL930062C patent/NL930062I2/en unknown
- 1993-06-24 LU LU88331C patent/LU88331I2/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1403263A1 (en) * | 2002-09-27 | 2004-03-31 | Council of Scientific and Industrial Research | Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0342, 920527 |
|
CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0342, 781103 |
|
CL | Concession to grant licences |