DK152050C - Analogifremgangsmaade til fremstilling af oxazolopyridiner - Google Patents

Analogifremgangsmaade til fremstilling af oxazolopyridiner

Info

Publication number
DK152050C
DK152050C DK284973A DK284973A DK152050C DK 152050 C DK152050 C DK 152050C DK 284973 A DK284973 A DK 284973A DK 284973 A DK284973 A DK 284973A DK 152050 C DK152050 C DK 152050C
Authority
DK
Denmark
Prior art keywords
oxazolopyridines
preparation
analogy procedure
analogy
procedure
Prior art date
Application number
DK284973A
Other languages
Danish (da)
English (en)
Other versions
DK152050B (da
Inventor
Tsung-Ying Shen
Robert Long Clark
Arsenio Alessandro Pessolano
Bruce Edward Witzel
Jr Thomas Joseph Lanza
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to DK357175A priority Critical patent/DK138456B/da
Publication of DK152050B publication Critical patent/DK152050B/da
Application granted granted Critical
Publication of DK152050C publication Critical patent/DK152050C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK284973A 1972-06-14 1973-05-24 Analogifremgangsmaade til fremstilling af oxazolopyridiner DK152050C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK357175A DK138456B (da) 1972-06-14 1975-08-06 Analogifremgangsmåde til fremstilling af oxazolo(4,5-b)pyridiner.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26289872A 1972-06-14 1972-06-14
US26289872 1972-06-14
BE147896A BE819177R (fr) 1972-06-14 1974-08-26 Oxazolo- et thiazolopyridines
BE147896 1974-08-26

Publications (2)

Publication Number Publication Date
DK152050B DK152050B (da) 1988-01-25
DK152050C true DK152050C (da) 1988-07-18

Family

ID=25648082

Family Applications (1)

Application Number Title Priority Date Filing Date
DK284973A DK152050C (da) 1972-06-14 1973-05-24 Analogifremgangsmaade til fremstilling af oxazolopyridiner

Country Status (17)

Country Link
JP (1) JPS5943475B2 (cs)
AR (1) AR208500A1 (cs)
AT (1) AT333277B (cs)
AU (1) AU472528B2 (cs)
BE (2) BE800868A (cs)
CA (1) CA1019741A (cs)
CS (1) CS178889B2 (cs)
DD (1) DD105237A5 (cs)
DE (1) DE2330109A1 (cs)
DK (1) DK152050C (cs)
FI (1) FI57417C (cs)
FR (1) FR2187356B1 (cs)
GB (1) GB1421619A (cs)
LU (1) LU67786A1 (cs)
NL (1) NL184836C (cs)
SE (2) SE401675B (cs)
ZA (1) ZA733760B (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527321A1 (de) * 1975-06-19 1976-12-23 Merck & Co Inc Oxazol eckige klammer auf 4,5-b eckige klammer zu pyridine
JPS527992A (en) * 1975-07-04 1977-01-21 Merck & Co Inc Oxazolo *4*55b* pyridines
NL187021C (nl) * 1975-07-15 1991-05-01 Merck & Co Inc Werkwijze ter bereiding van een farmaceutisch preparaat met anti-inflammatoire werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte anti-inflammatoir werkzame 2-fenyl-oxazolo-(4,5-b)pyridinederivaten.
US4011326A (en) * 1975-07-29 1977-03-08 Merck & Co., Inc. 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
DE2862462D1 (de) * 1977-08-12 1985-05-15 Ici Plc 2-chloro-5-trichloromethylpyridine
JPS5461182A (en) * 1977-10-20 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-phenoxy-5-trifluoromethylpyridine compounds
JPS5461183A (en) * 1977-10-21 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-substituted-5-trifluoromethyl pyridine compounds
JPH0224818B2 (cs) * 1978-02-15 1990-05-30 Imuperiaru Chem Ind Plc
JPS55130840U (cs) * 1979-03-12 1980-09-16
JPS55124763A (en) * 1979-03-19 1980-09-26 Ishihara Sangyo Kaisha Ltd 5-trifluoromethyl-2-pyridone derivative
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
FR2652085A1 (fr) * 1989-09-20 1991-03-22 Science Organisation Nouveau procede de synthese de derives d'oxazolopyridines.
DE59711147D1 (de) * 1996-11-11 2004-01-29 Altana Pharma Ag Neue Imidazo- und Oxazolopyridine als Phosphodiesterase Inhibitoren.
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
TR200100189T2 (tr) * 1998-06-04 2001-05-21 Abbott Laboratories Hücre yapışması engelleyici iltihaplanmaya karşı bileşikler
HK1045306A1 (zh) * 1999-06-03 2002-11-22 Abbott Laboratories 抑制细胞黏附的抗炎化合物
WO2002036580A2 (en) * 2000-10-31 2002-05-10 Lynn Bonham Benzoxazole lpaat- beta inhibitors and uses thereof
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
AU2006278504B2 (en) 2005-08-04 2013-01-17 Sirtris Pharmaceuticals, Inc. Imidazopyridine derivatives as sirtuin modulating agents
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
JP5734853B2 (ja) * 2008-08-29 2015-06-17 トレヴェンティス コーポレイションＴｒｅｖｅｎｔｉｓ Ｃｏｒｐｏｒａｔｉｏｎ 神経系疾患用の診断ツール及び治療としてのブチリルコリンエステラーゼリガンド
NZ594122A (en) 2008-12-19 2013-03-28 Sirtris Pharmaceuticals Inc 2-Phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide derivatives
TW201114762A (en) * 2009-09-30 2011-05-01 Sumitomo Chemical Co Composition and method for controlling arthropod pests
CA2812087A1 (en) * 2010-09-15 2012-03-22 F. Hoffmann-La Roche Ag Azabenzothiazole compounds, compositions and methods of use
US8853238B2 (en) * 2010-12-24 2014-10-07 Sumitomo Chemical Company, Limited Fused heterocyclic compound and use thereof for pest control
WO2015200650A1 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
EP3227302B1 (de) 2014-12-02 2018-07-11 Bayer CropScience AG Bicyclische verbindungen als schädlingsbekämpfungsmittel
US10399966B2 (en) 2016-01-21 2019-09-03 University Of Washington Compounds for treatment of trypanosomes and neurological pathogens and uses thereof
JP7430486B2 (ja) * 2016-07-07 2024-02-13 保土谷化学工業株式会社 ベンゾアゾール環構造を有する化合物および有機エレクトロルミネッセンス素子

Also Published As

Publication number Publication date
BE819177R (fr) 1975-02-26
FR2187356B1 (cs) 1977-01-28
DK152050B (da) 1988-01-25
DD105237A5 (cs) 1974-04-12
GB1421619A (en) 1976-01-21
JPS5943475B2 (ja) 1984-10-22
JPS4961195A (cs) 1974-06-13
CS178889B2 (en) 1977-10-31
FR2187356A1 (cs) 1974-01-18
NL7307582A (cs) 1973-12-18
AU5651173A (en) 1974-12-05
CA1019741A (en) 1977-10-25
SE7604385L (sv) 1976-04-14
LU67786A1 (cs) 1973-08-16
AT333277B (de) 1976-11-10
DE2330109A1 (de) 1974-01-03
ATA508673A (de) 1976-03-15
AU472528B2 (en) 1976-05-27
BE800868A (fr) 1973-12-13
FI57417C (fi) 1980-08-11
SE401675B (sv) 1978-05-22
NL184836C (nl) 1989-11-16
ZA733760B (en) 1975-01-29
AR208500A1 (es) 1977-02-15
NL184836B (nl) 1989-06-16
FI57417B (fi) 1980-04-30
SE432767B (sv) 1984-04-16

Similar Documents

Publication Publication Date Title
DK152050C (da) Analogifremgangsmaade til fremstilling af oxazolopyridiner
DK513578A (da) Fremgangsmaade til fremstilling af triazolylbenzopenoner
DK145676C (da) Analogifremgangsmaade til fremstilling af oxoalkyldialkylxanthiner
DK158466C (da) Analogifremgangsmaade til fremstilling af et alkanolaminderivat
DK134177C (da) Fremgangsmade til fremstilling af 3-(piperazinoalkyl)-pyrazoler
DK139966C (da) Fremgangsmaade til fremstilling af 1-hydroxy-2-pyridoner
DK145878C (da) Analogifremgangsmaade til fremstilling af alkylthiocyclopentanderivater
DK136062C (da) Fremgangsmade til fremstilling af 2-alkylamino-dihydropyridiner
DK139751B (da) Analogifremgangsmaade til fremstilling af n-benzhydryl-n!-p-hydroxybenzyl-piperaziner
DK144270C (da) Analogifremgangsmaade til fremstilling af n-carbamoyl-2-phenylethensulfonamider
DK132273C (da) Fremgangsmade til fremstilling af trans-chrysanthemsyre
DK134782C (da) Fremgangsmade til fremstilling af 3beta-hydroxy-5beta-h-steroider
DK139524B (da) Fremgangsmaade til fremstilling af poly-alfahydroxy-acrylsyre
DK131855C (da) Fremgangsmade til fremstilling af 3,4-dihydropyridoner
DK143847C (da) Analogifremgangsmaade til fremstilling af imidazolderivater
DK139270C (da) Fremgangsmaade til fremstilling af alfa-kobberphthalocyanin
DK132586C (da) Fremgangsmade til fremstilling af erythromycylaminer
DK141530C (da) Analogifremgangsmaade til fremstilling af lactamer
DK238090A (da) Fremgangsmaade til fremstilling af benzocycloheptathiophenderivater
NO148849C (no) Analogifremgangsmaate for fremstilling av krystallinsk pivaloyloksymetyl-d-(-)-alfa-aminobenzylpenicillinat
DK144872C (da) Fremgangsmaade til fremstilling af pyrazolonholdige tabletter
DK132409C (da) Fremgangsmade til fremstilling af heterocyclisk substitueredemalonatestere
DK133777C (da) Fremgangsmade til fremstilling af alfa-oximinonitriler
DK131786C (da) Fremgangsmade til fremstilling af delta4-3-oxo-1alfa-methylsteroider
DK132283C (da) Analogifremgangsmade til fremstilling af 15-oxasteroider

Legal Events

Date Code Title Description
PBP Patent lapsed