GB1421619A - Oxazolopyridines and thiazolopyridines - Google Patents
Oxazolopyridines and thiazolopyridinesInfo
- Publication number
- GB1421619A GB1421619A GB2763273A GB2763273A GB1421619A GB 1421619 A GB1421619 A GB 1421619A GB 2763273 A GB2763273 A GB 2763273A GB 2763273 A GB2763273 A GB 2763273A GB 1421619 A GB1421619 A GB 1421619A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- amino
- pyridines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1421619 Oxazolo- and thiazolo-pyridines MERCK & CO Inc 11 June 1973 [14 June 1972] 27632/73 Heading C2C The invention comprises novel compounds (I) in which the six membered ring is a pyridine with the N at one of the unsubstituted positions, or an N-oxide or quaternary pyridinium salt thereof, in which Y is O or S, R is (a) where n is 0, 1, 2, 3, 4 or 5 and, when n is 2 or more, the X substituents are similar or dissimilar, X is a halogen atom or a C 1-3 alkoxy, C 1-5 alkyl, nitro, phenyl, C 1-3 alkylsulphonyl, C 1-3 trihaloalkyl, cyano, C 1-3 alkylthio, carbamoyl, symmetrical or asymmetrical di- (C 1-3 alkyl)amino, C 1-3 alkylamino, C 1-3 alkylsulphinyl, mercapto, trifluoromethoxy, C 2-5 alkanoyloxy, hydroxy, C 2-5 alkanoylamino, amino, benzoylamine, halobenzoylamino, (C 1-3 alkyl) benzoylamine or (C 1-3 alkoxy)- benzoylamino radical, or a radical of formula -COOR<SP>2</SP>, -(CH 2 ) w COOR<SP>2</SP> or -(CH 2 ) w CN, in which w is 1, 2 or 3 and each R<SP>2</SP>, which may be the same as or different from any other R<SP>2</SP>, is hydrogen or C 1-3 alkyl; or two X radicals on adjacent carbons are linked together to form a methylenedioxy group; or (b) (c) a 5-6 membered heterocycle containing up to 2 heteroatoms selected from O, N and S; (d) naphthyl or (e) adamantanyl; R<SP>1</SP> is a halogen atom or a C 1-5 alkyl, nitro, C 1-3 trihaloalkyl, amino, benzoylamine, C 1-3 alkoxy, symmetrical or asymmetrical di(C 1-3 alkyl)amino, C 1-3 alkylamine, phenyl, (C 1-3 alkoxy)-carbonylamine, or cyano group; and m is 0, 1 or 2 with the proviso that R is not phenyl, 4-halophenyl, 4-(C 1-3 alkoxy)phenyl, 4-(C 1-5 alkyl)phenyl, 4-nitrophenyl or 4-aminophenyl. They are made by standard methods by cyclization of corresponding amino-hydroxy-pyridines or mercaptoaminopyridines; intermediate amides can be isolated and subsequently either ring closed to give the oxazolo-pyridines, or treated with P 2 S 5 to give the thiazolo-pyridines. Pharmaceutical preparations having antiinflammatory, antipyretic and analgesic actions contain (I) as above defined, but without the proviso, and/or (I) where R can also be (where A is C 1-3 alkylene or C 2-5 alkenylene), C 1-5 alkyl or C 3-7 cycloalkyl, as active ingredient. Standard forms of administration are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26289872A | 1972-06-14 | 1972-06-14 | |
BE147896A BE819177R (en) | 1972-06-14 | 1974-08-26 | OXAZOLO- AND THIAZOLOPYRIDINES |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1421619A true GB1421619A (en) | 1976-01-21 |
Family
ID=25648082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2763273A Expired GB1421619A (en) | 1972-06-14 | 1973-06-11 | Oxazolopyridines and thiazolopyridines |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5943475B2 (en) |
AR (1) | AR208500A1 (en) |
AT (1) | AT333277B (en) |
AU (1) | AU472528B2 (en) |
BE (2) | BE800868A (en) |
CA (1) | CA1019741A (en) |
CS (1) | CS178889B2 (en) |
DD (1) | DD105237A5 (en) |
DE (1) | DE2330109A1 (en) |
DK (1) | DK152050C (en) |
FI (1) | FI57417C (en) |
FR (1) | FR2187356B1 (en) |
GB (1) | GB1421619A (en) |
LU (1) | LU67786A1 (en) |
NL (1) | NL184836C (en) |
SE (2) | SE401675B (en) |
ZA (1) | ZA733760B (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0001473A2 (en) * | 1977-08-12 | 1979-04-18 | Imperial Chemical Industries Plc | Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith |
DE3008908A1 (en) * | 1979-03-19 | 1980-10-02 | Ishihara Mining & Chemical Co | TRIFLUOROMETHYL-2-(THIO)-PYRIDONE COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
DE3445192A1 (en) * | 1983-12-16 | 1985-06-27 | Farmitalia Carlo Erba S.p.A., Mailand/Milano | 4,5,6,7-TETRAHYDROTHIAZOLO (5,4-C) PYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS |
EP0003877B1 (en) * | 1978-02-15 | 1988-02-03 | Imperial Chemical Industries Plc | Herbicidal derivatives of 2-(4(2-pyridyloxy)phenoxy)propane, processes for preparing them, and herbicidal compositions containing them |
US4753673A (en) * | 1977-07-22 | 1988-06-28 | The Dow Chemical Company | Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use |
WO2002036580A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7893086B2 (en) | 2007-06-20 | 2011-02-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8163908B2 (en) | 2005-08-04 | 2012-04-24 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8343997B2 (en) | 2008-12-19 | 2013-01-01 | Sirtris Pharmaceuticals, Inc. | Thiazolopyridine sirtuin modulating compounds |
US8697708B2 (en) | 2010-09-15 | 2014-04-15 | F. Hoffmann-La Roche Ag | Azabenzothiazole compounds, compositions and methods of use |
US9278983B2 (en) | 2010-12-24 | 2016-03-08 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound and use thereof for pest control |
WO2017127627A1 (en) * | 2016-01-21 | 2017-07-27 | The University Of North Carolina At Chapel Hill | Compounds for treatment of trypanosomes and neurological pathogens and uses thereof |
CN109790132A (en) * | 2016-07-07 | 2019-05-21 | 保土谷化学工业株式会社 | Compound and organic electroluminescent device with benzoxazole ring structure |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2527321A1 (en) * | 1975-06-19 | 1976-12-23 | Merck & Co Inc | 2-(Substd phenyl) oxazolo (4,5-b) pyridines - topical anti-inflammatories with very low systemic activity |
JPS527992A (en) * | 1975-07-04 | 1977-01-21 | Merck & Co Inc | Oxazolo *4*55b* pyridines |
NL187021C (en) * | 1975-07-15 | 1991-05-01 | Merck & Co Inc | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH ANTI-INFLAMMATORY ACTION, AND A METHOD FOR PREPARING ANTI-INFLAMMATIC ACTIVITY 2-PHENYL-OXAZOLO-PID-BIDANE. |
US4011326A (en) * | 1975-07-29 | 1977-03-08 | Merck & Co., Inc. | 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents |
JPS5461182A (en) * | 1977-10-20 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-phenoxy-5-trifluoromethylpyridine compounds |
JPS5461183A (en) * | 1977-10-21 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-substituted-5-trifluoromethyl pyridine compounds |
JPS55130840U (en) * | 1979-03-12 | 1980-09-16 | ||
FR2652085A1 (en) * | 1989-09-20 | 1991-03-22 | Science Organisation | NEW PROCESS FOR THE SYNTHESIS OF OXAZOLOPYRIDINE DERIVATIVES |
DK0937075T3 (en) * | 1996-11-11 | 2004-04-13 | Altana Pharma Ag | New imidazo and oxazolopyridines as phosphodiesterase inhibitors |
TR200100189T2 (en) * | 1998-06-04 | 2001-05-21 | Abbott Laboratories | Anti-inflammatory compounds against cell adhesion |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
JP5734853B2 (en) * | 2008-08-29 | 2015-06-17 | トレヴェンティス コーポレイションTreventis Corporation | Butyrylcholinesterase ligand as a diagnostic tool and therapy for nervous system diseases |
AR078463A1 (en) * | 2009-09-30 | 2011-11-09 | Sumitomo Chemical Co | COMPOSITION AND METHOD TO CONTROL PESTS OF ARTROPODES |
US20170217941A1 (en) * | 2014-06-25 | 2017-08-03 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
ES2691246T3 (en) | 2014-12-02 | 2018-11-26 | Bayer Cropscience Ag | Bicyclic compounds such as pesticides |
-
1973
- 1973-03-12 AR AR248527A patent/AR208500A1/en active
- 1973-05-22 FI FI1657/73A patent/FI57417C/en active
- 1973-05-24 DK DK284973A patent/DK152050C/en not_active IP Right Cessation
- 1973-05-25 SE SE7307412A patent/SE401675B/en unknown
- 1973-05-30 NL NLAANVRAGE7307582,A patent/NL184836C/en not_active IP Right Cessation
- 1973-06-04 AU AU56511/73A patent/AU472528B2/en not_active Expired
- 1973-06-04 ZA ZA00733760A patent/ZA733760B/en unknown
- 1973-06-05 CA CA173,275A patent/CA1019741A/en not_active Expired
- 1973-06-08 AT AT508673A patent/AT333277B/en active
- 1973-06-11 GB GB2763273A patent/GB1421619A/en not_active Expired
- 1973-06-12 DD DD171559A patent/DD105237A5/xx unknown
- 1973-06-12 CS CS7300004243A patent/CS178889B2/en unknown
- 1973-06-13 LU LU67786A patent/LU67786A1/xx unknown
- 1973-06-13 BE BE132231A patent/BE800868A/en not_active IP Right Cessation
- 1973-06-13 FR FR7321443A patent/FR2187356B1/fr not_active Expired
- 1973-06-13 DE DE2330109A patent/DE2330109A1/en not_active Withdrawn
- 1973-06-14 JP JP48066453A patent/JPS5943475B2/en not_active Expired
-
1974
- 1974-08-26 BE BE147896A patent/BE819177R/en not_active IP Right Cessation
-
1976
- 1976-04-14 SE SE7604385A patent/SE432767B/en not_active IP Right Cessation
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753673A (en) * | 1977-07-22 | 1988-06-28 | The Dow Chemical Company | Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use |
EP0001473A2 (en) * | 1977-08-12 | 1979-04-18 | Imperial Chemical Industries Plc | Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith |
EP0107866A2 (en) * | 1977-08-12 | 1984-05-09 | Imperial Chemical Industries Plc | Trihalomethylpyridine compounds |
DK157296B (en) * | 1977-08-12 | 1989-12-04 | Ici Ltd | 2-CHLORO-PYRIDE COMPOUNDS FOR USE AS BASIC MATERIALS IN THE PREPARATION OF HERBICIDE PYRIDE COMPOUNDS |
EP0001473B1 (en) * | 1977-08-12 | 1988-07-27 | Imperial Chemical Industries Plc | Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith |
EP0028870B1 (en) * | 1977-08-12 | 1988-03-16 | Imperial Chemical Industries Plc | Phenoxypyridine compound |
EP0107866B1 (en) * | 1977-08-12 | 1988-03-30 | Imperial Chemical Industries Plc | Trihalomethylpyridine compounds |
EP0003877B1 (en) * | 1978-02-15 | 1988-02-03 | Imperial Chemical Industries Plc | Herbicidal derivatives of 2-(4(2-pyridyloxy)phenoxy)propane, processes for preparing them, and herbicidal compositions containing them |
US4546191A (en) * | 1979-03-19 | 1985-10-08 | Ishihara Sangyo Kaisha Ltd. | Trifluoromethyl-2-pyridinone or pyridinthione compounds and process for the preparation of the same |
DE3008908A1 (en) * | 1979-03-19 | 1980-10-02 | Ishihara Mining & Chemical Co | TRIFLUOROMETHYL-2-(THIO)-PYRIDONE COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
DE3445192A1 (en) * | 1983-12-16 | 1985-06-27 | Farmitalia Carlo Erba S.p.A., Mailand/Milano | 4,5,6,7-TETRAHYDROTHIAZOLO (5,4-C) PYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS |
WO2002036580A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
WO2002036580A3 (en) * | 2000-10-31 | 2002-09-06 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
US8178536B2 (en) | 2005-08-04 | 2012-05-15 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8163908B2 (en) | 2005-08-04 | 2012-04-24 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7893086B2 (en) | 2007-06-20 | 2011-02-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8268862B2 (en) | 2007-06-20 | 2012-09-18 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8343997B2 (en) | 2008-12-19 | 2013-01-01 | Sirtris Pharmaceuticals, Inc. | Thiazolopyridine sirtuin modulating compounds |
US8492401B2 (en) | 2008-12-19 | 2013-07-23 | Glaxosmithkline Llc | Thiazolopyridine sirtuin modulating compounds |
US8697708B2 (en) | 2010-09-15 | 2014-04-15 | F. Hoffmann-La Roche Ag | Azabenzothiazole compounds, compositions and methods of use |
US9278983B2 (en) | 2010-12-24 | 2016-03-08 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound and use thereof for pest control |
WO2017127627A1 (en) * | 2016-01-21 | 2017-07-27 | The University Of North Carolina At Chapel Hill | Compounds for treatment of trypanosomes and neurological pathogens and uses thereof |
US10399966B2 (en) | 2016-01-21 | 2019-09-03 | University Of Washington | Compounds for treatment of trypanosomes and neurological pathogens and uses thereof |
CN109790132A (en) * | 2016-07-07 | 2019-05-21 | 保土谷化学工业株式会社 | Compound and organic electroluminescent device with benzoxazole ring structure |
CN109790132B (en) * | 2016-07-07 | 2024-03-05 | 保土谷化学工业株式会社 | Compound having benzoxazole ring structure and organic electroluminescent element |
Also Published As
Publication number | Publication date |
---|---|
JPS5943475B2 (en) | 1984-10-22 |
FR2187356A1 (en) | 1974-01-18 |
FR2187356B1 (en) | 1977-01-28 |
NL184836B (en) | 1989-06-16 |
DK152050C (en) | 1988-07-18 |
AR208500A1 (en) | 1977-02-15 |
FI57417C (en) | 1980-08-11 |
CA1019741A (en) | 1977-10-25 |
SE7604385L (en) | 1976-04-14 |
NL7307582A (en) | 1973-12-18 |
SE432767B (en) | 1984-04-16 |
DK152050B (en) | 1988-01-25 |
SE401675B (en) | 1978-05-22 |
FI57417B (en) | 1980-04-30 |
JPS4961195A (en) | 1974-06-13 |
LU67786A1 (en) | 1973-08-16 |
AU5651173A (en) | 1974-12-05 |
DE2330109A1 (en) | 1974-01-03 |
BE800868A (en) | 1973-12-13 |
BE819177R (en) | 1975-02-26 |
NL184836C (en) | 1989-11-16 |
AU472528B2 (en) | 1976-05-27 |
DD105237A5 (en) | 1974-04-12 |
CS178889B2 (en) | 1977-10-31 |
ZA733760B (en) | 1975-01-29 |
ATA508673A (en) | 1976-03-15 |
AT333277B (en) | 1976-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1421619A (en) | Oxazolopyridines and thiazolopyridines | |
GB1384031A (en) | N-substituted dihydropyridine compounds their production and their medicinal use | |
NO146162C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS | |
GB1457078A (en) | Pyrazolo pyridine derivatives | |
NZ219193A (en) | Piperazinyl pyridines and piperinyl-imidazoles and pharmaceutical compositions; intermediates | |
FR2406641A1 (en) | 2,6-DIAMINONEBULARINS AND THEIR THERAPEUTIC APPLICATION | |
BG98124A (en) | Active pyrrole-(2,3-)pyridine derivatives | |
ES448588A1 (en) | Acylamino derivatives | |
ES8305366A1 (en) | Antibacterial penem derivatives. | |
FR2386523A1 (en) | PROSTANE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING IT | |
FR2378026A1 (en) | MEDICINAL PRODUCTS CONTAINING DERIVATIVES OF HYDROXYMETHYL-2-AMINO-2'-DIPHENYL SULFIDE | |
GB1530413A (en) | 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines | |
FR2355830A1 (en) | NEW DERIVATIVES OF 6-7-BENZOMORPHANE, THEIR OBTAINING AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | |
GB1184044A (en) | Nitrofuryl-Oxadiazole Derivatives | |
GB1364407A (en) | Thiocarbamic acid derivatives | |
NO772530L (en) | ANALOGICAL PROCEDURE FOR THE PREPARATION OF N- (1`-ALLYL-2`-PYRROLIDYLMethyl) -2,3-DIMETOXY-5-SULFAMOYL BENZAMIDES AND DERIVATIVES THEREOF | |
FR2333508A1 (en) | NEW DERIVATIVES OF 3-AZA-BICYCLO (3.1.0) HEXANE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS | |
IE37370B1 (en) | New 2,6-diamino-dihydropyridines their production and their medicinal use | |
ATE88176T1 (en) | 2-HYDROXY-3-ARYLOXY-PROPYLAMINE DERIVATIVES WITH CARDIOVASCULAR ACTIVITIES. | |
GB1513702A (en) | 4-substituted pyrazole derivatives processes for their preparation and their use as medicaments | |
GB1509840A (en) | Phenylsulphenylpiperazines | |
GB1408984A (en) | Beta-adrenergic blocking aminopropanols | |
GB1173304A (en) | A Process for the Manufacture of Benzoxadiaz[4,1,5]Ocines | |
GB1368546A (en) | Partially hydrogenated benzoquinolizines their manufacture and their medicinal use | |
ZM3275A1 (en) | New n-(1-benzylpyrrolidinyl 2-alkyl) substituted benzamides, their derivatives and its process of preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920611 |