AT333277B - PROCESS FOR THE PREPARATION OF NEW OXAZOLE PYRIDINES AND THEIR N-OXIDES AND QUATERNAR PYRIDINIUM SALTS - Google Patents
PROCESS FOR THE PREPARATION OF NEW OXAZOLE PYRIDINES AND THEIR N-OXIDES AND QUATERNAR PYRIDINIUM SALTSInfo
- Publication number
- AT333277B AT333277B AT508673A AT508673A AT333277B AT 333277 B AT333277 B AT 333277B AT 508673 A AT508673 A AT 508673A AT 508673 A AT508673 A AT 508673A AT 333277 B AT333277 B AT 333277B
- Authority
- AT
- Austria
- Prior art keywords
- quaternar
- pyridines
- oxides
- preparation
- pyridinium salts
- Prior art date
Links
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26289872A | 1972-06-14 | 1972-06-14 | |
| BE147896A BE819177R (en) | 1972-06-14 | 1974-08-26 | OXAZOLO- AND THIAZOLOPYRIDINES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA508673A ATA508673A (en) | 1976-03-15 |
| AT333277B true AT333277B (en) | 1976-11-10 |
Family
ID=25648082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT508673A AT333277B (en) | 1972-06-14 | 1973-06-08 | PROCESS FOR THE PREPARATION OF NEW OXAZOLE PYRIDINES AND THEIR N-OXIDES AND QUATERNAR PYRIDINIUM SALTS |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5943475B2 (en) |
| AR (1) | AR208500A1 (en) |
| AT (1) | AT333277B (en) |
| AU (1) | AU472528B2 (en) |
| BE (2) | BE800868A (en) |
| CA (1) | CA1019741A (en) |
| CS (1) | CS178889B2 (en) |
| DD (1) | DD105237A5 (en) |
| DE (1) | DE2330109A1 (en) |
| DK (1) | DK152050C (en) |
| FI (1) | FI57417C (en) |
| FR (1) | FR2187356B1 (en) |
| GB (1) | GB1421619A (en) |
| LU (1) | LU67786A1 (en) |
| NL (1) | NL184836C (en) |
| SE (2) | SE401675B (en) |
| ZA (1) | ZA733760B (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2527321A1 (en) * | 1975-06-19 | 1976-12-23 | Merck & Co Inc | 2-(Substd phenyl) oxazolo (4,5-b) pyridines - topical anti-inflammatories with very low systemic activity |
| JPS527992A (en) * | 1975-07-04 | 1977-01-21 | Merck & Co Inc | Oxazolo *4*55b* pyridines |
| NL187021C (en) * | 1975-07-15 | 1991-05-01 | Merck & Co Inc | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH ANTI-INFLAMMATORY ACTION, AND A METHOD FOR PREPARING ANTI-INFLAMMATIC ACTIVITY 2-PHENYL-OXAZOLO-PID-BIDANE. |
| US4011326A (en) * | 1975-07-29 | 1977-03-08 | Merck & Co., Inc. | 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents |
| US4753673A (en) * | 1977-07-22 | 1988-06-28 | The Dow Chemical Company | Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use |
| DE2862490D1 (en) | 1977-08-12 | 1988-04-21 | Ici Plc | Phenoxypyridine compound |
| JPS5461182A (en) * | 1977-10-20 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-phenoxy-5-trifluoromethylpyridine compounds |
| JPS5461183A (en) * | 1977-10-21 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-substituted-5-trifluoromethyl pyridine compounds |
| WO1979000624A1 (en) * | 1978-02-15 | 1979-09-06 | Ici Ltd | Herbicidal derivatives of 2-(4(2-pyridyloxy)phenoxy)propane,processes for preparing them,and herbicidal compositions containing them |
| JPS55130840U (en) * | 1979-03-12 | 1980-09-16 | ||
| JPS55124763A (en) * | 1979-03-19 | 1980-09-26 | Ishihara Sangyo Kaisha Ltd | 5-trifluoromethyl-2-pyridone derivative |
| GB8333514D0 (en) * | 1983-12-16 | 1984-01-25 | Erba Farmitalia | Tetrahydrothiazolo(5 4-c)pyridine derivatives |
| FR2652085A1 (en) * | 1989-09-20 | 1991-03-22 | Science Organisation | NEW PROCESS FOR THE SYNTHESIS OF OXAZOLOPYRIDINE DERIVATIVES |
| DK0937075T3 (en) * | 1996-11-11 | 2004-04-13 | Altana Pharma Ag | New imidazo and oxazolopyridines as phosphodiesterase inhibitors |
| IL139811A0 (en) * | 1998-06-04 | 2002-02-10 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| HK1045306A1 (en) * | 1999-06-03 | 2002-11-22 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| WO2002036580A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Benzoxazole lpaat- beta inhibitors and uses thereof |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| CA2618370A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| CL2008001822A1 (en) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compounds derived from thiazolo [5,4-b] pyridine; pharmaceutical composition comprising said compounds; and use of the compound in the treatment of insulin resistance, metabolic syndrome, diabetes, among others. |
| JP5734853B2 (en) * | 2008-08-29 | 2015-06-17 | トレヴェンティス コーポレイションＴｒｅｖｅｎｔｉｓ Ｃｏｒｐｏｒａｔｉｏｎ | Butyrylcholinesterase ligand as a diagnostic tool and therapy for nervous system diseases |
| JP5628828B2 (en) | 2008-12-19 | 2014-11-19 | サートリス ファーマシューティカルズ， インコーポレイテッド | Thiazolopyridine sirtuin-modulating compound |
| TW201114762A (en) * | 2009-09-30 | 2011-05-01 | Sumitomo Chemical Co | Composition and method for controlling arthropod pests |
| RU2013114352A (en) | 2010-09-15 | 2014-10-20 | Ф. Хоффманн-Ля Рош Аг | AZABENZENESIAZOLES, COMPOSITIONS AND METHODS OF APPLICATION |
| PH12013501178A1 (en) | 2010-12-24 | 2013-07-15 | Sumitomo Chemical Co | Fused heterocyclic compound and use for pest control thereof |
| US20170217941A1 (en) * | 2014-06-25 | 2017-08-03 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
| CN107207529A (en) | 2014-12-02 | 2017-09-26 | 拜耳作物科学股份公司 | Bicyclic compounds as pest control agents |
| US10399966B2 (en) | 2016-01-21 | 2019-09-03 | University Of Washington | Compounds for treatment of trypanosomes and neurological pathogens and uses thereof |
| WO2018008718A1 (en) * | 2016-07-07 | 2018-01-11 | 保土谷化学工業株式会社 | Compound having benzazole ring structure and organic electroluminescent element |
-
1973
- 1973-03-12 AR AR248527A patent/AR208500A1/en active
- 1973-05-22 FI FI1657/73A patent/FI57417C/en active
- 1973-05-24 DK DK284973A patent/DK152050C/en not_active IP Right Cessation
- 1973-05-25 SE SE7307412A patent/SE401675B/en unknown
- 1973-05-30 NL NLAANVRAGE7307582,A patent/NL184836C/en not_active IP Right Cessation
- 1973-06-04 ZA ZA00733760A patent/ZA733760B/en unknown
- 1973-06-04 AU AU56511/73A patent/AU472528B2/en not_active Expired
- 1973-06-05 CA CA173,275A patent/CA1019741A/en not_active Expired
- 1973-06-08 AT AT508673A patent/AT333277B/en active
- 1973-06-11 GB GB2763273A patent/GB1421619A/en not_active Expired
- 1973-06-12 DD DD171559A patent/DD105237A5/xx unknown
- 1973-06-12 CS CS7300004243A patent/CS178889B2/en unknown
- 1973-06-13 FR FR7321443A patent/FR2187356B1/fr not_active Expired
- 1973-06-13 DE DE2330109A patent/DE2330109A1/en not_active Withdrawn
- 1973-06-13 LU LU67786A patent/LU67786A1/xx unknown
- 1973-06-13 BE BE132231A patent/BE800868A/en not_active IP Right Cessation
- 1973-06-14 JP JP48066453A patent/JPS5943475B2/en not_active Expired
-
1974
- 1974-08-26 BE BE147896A patent/BE819177R/en not_active IP Right Cessation
-
1976
- 1976-04-14 SE SE7604385A patent/SE432767B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4961195A (en) | 1974-06-13 |
| SE7604385L (en) | 1976-04-14 |
| CA1019741A (en) | 1977-10-25 |
| GB1421619A (en) | 1976-01-21 |
| LU67786A1 (en) | 1973-08-16 |
| FR2187356A1 (en) | 1974-01-18 |
| AR208500A1 (en) | 1977-02-15 |
| DD105237A5 (en) | 1974-04-12 |
| FI57417C (en) | 1980-08-11 |
| DK152050B (en) | 1988-01-25 |
| ATA508673A (en) | 1976-03-15 |
| DK152050C (en) | 1988-07-18 |
| AU5651173A (en) | 1974-12-05 |
| ZA733760B (en) | 1975-01-29 |
| BE800868A (en) | 1973-12-13 |
| AU472528B2 (en) | 1976-05-27 |
| JPS5943475B2 (en) | 1984-10-22 |
| SE401675B (en) | 1978-05-22 |
| BE819177R (en) | 1975-02-26 |
| DE2330109A1 (en) | 1974-01-03 |
| FI57417B (en) | 1980-04-30 |
| FR2187356B1 (en) | 1977-01-28 |
| SE432767B (en) | 1984-04-16 |
| CS178889B2 (en) | 1977-10-31 |
| NL184836B (en) | 1989-06-16 |
| NL7307582A (en) | 1973-12-18 |
| NL184836C (en) | 1989-11-16 |
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