DK1519756T3 - Anvendelse af perfluoralkylholdige metalkomplekser som kontrastmiddel i MR-imaging til visning af intravasale tromber - Google Patents

Anvendelse af perfluoralkylholdige metalkomplekser som kontrastmiddel i MR-imaging til visning af intravasale tromber

Info

Publication number
DK1519756T3
DK1519756T3 DK03740431T DK03740431T DK1519756T3 DK 1519756 T3 DK1519756 T3 DK 1519756T3 DK 03740431 T DK03740431 T DK 03740431T DK 03740431 T DK03740431 T DK 03740431T DK 1519756 T3 DK1519756 T3 DK 1519756T3
Authority
DK
Denmark
Prior art keywords
intravasal
thrombi
perfluoroalkyl
display
contrast agent
Prior art date
Application number
DK03740431T
Other languages
Danish (da)
English (en)
Inventor
Bernd Misselwitz
Johannes Platzek
Yoko Kawata
Hanns-Joachim Weinmann
Takishi Yokawa
Ulrich Niedballa
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of DK1519756T3 publication Critical patent/DK1519756T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03740431T 2002-07-10 2003-07-05 Anvendelse af perfluoralkylholdige metalkomplekser som kontrastmiddel i MR-imaging til visning af intravasale tromber DK1519756T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231799A DE10231799B4 (de) 2002-07-10 2002-07-10 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
PCT/EP2003/007274 WO2004006965A2 (fr) 2002-07-10 2003-07-05 Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste en imagerie par resonance magnetique pour la representation de thrombus intravasculaires

Publications (1)

Publication Number Publication Date
DK1519756T3 true DK1519756T3 (da) 2007-08-13

Family

ID=30009959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03740431T DK1519756T3 (da) 2002-07-10 2003-07-05 Anvendelse af perfluoralkylholdige metalkomplekser som kontrastmiddel i MR-imaging til visning af intravasale tromber

Country Status (23)

Country Link
EP (1) EP1519756B1 (fr)
JP (1) JP2005532404A (fr)
CN (1) CN1668338A (fr)
AR (1) AR041187A1 (fr)
AT (1) ATE361103T1 (fr)
AU (2) AU2003281146A1 (fr)
BR (1) BR0312552A (fr)
CA (1) CA2491933A1 (fr)
DE (2) DE10231799B4 (fr)
DK (1) DK1519756T3 (fr)
ES (1) ES2285143T3 (fr)
IL (1) IL165889A0 (fr)
MX (1) MXPA04012950A (fr)
NO (1) NO20050679L (fr)
PE (1) PE20040656A1 (fr)
PL (1) PL374027A1 (fr)
PT (1) PT1519756E (fr)
RS (1) RS20050020A (fr)
RU (1) RU2328310C2 (fr)
TW (1) TW200413008A (fr)
UA (1) UA79294C2 (fr)
WO (2) WO2004006979A2 (fr)
ZA (1) ZA200501172B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
EP2373622A2 (fr) * 2008-12-05 2011-10-12 Molecular Insight Pharmaceuticals, Inc. Produits radiopharmaceutiques spécifiques de ca-ix pour le traitement et l'imagerie de cancer
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法
EP4059925A1 (fr) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft Nouvel agent de contraste pour une utilisation dans l'imagerie par résonance magnétique
EP4335840A1 (fr) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft Nouveaux agents de contraste pour l'imagerie diagnostique
EP4335462A1 (fr) 2022-09-09 2024-03-13 Bayer AG Nouveaux agents de contraste pour l'imagerie diagnostique par tomodensitometrie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
AU4753997A (en) * 1996-10-16 1998-05-11 Burnham Institute, The Magnetic resonance imaging of thrombi
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
EA200200220A1 (ru) * 1999-07-29 2002-08-29 Эпикс Медикал, Инк. Нацеливающие мультимерные визуализирующие агенты с механизмом мультилокусного связывания
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Also Published As

Publication number Publication date
RU2328310C2 (ru) 2008-07-10
PL374027A1 (en) 2005-09-19
NO20050679L (no) 2005-04-08
EP1519756B1 (fr) 2007-05-02
RS20050020A (en) 2007-08-03
AU2003281146A1 (en) 2004-02-02
CN1668338A (zh) 2005-09-14
TW200413008A (en) 2004-08-01
PE20040656A1 (es) 2004-12-01
AR041187A1 (es) 2005-05-04
AU2003281150A1 (en) 2004-02-02
WO2004006965A2 (fr) 2004-01-22
PT1519756E (pt) 2007-07-12
CA2491933A1 (fr) 2004-01-22
BR0312552A (pt) 2005-04-26
ES2285143T3 (es) 2007-11-16
DE10231799B4 (de) 2006-10-05
WO2004006979A2 (fr) 2004-01-22
DE10231799A1 (de) 2004-02-12
DE50307180D1 (de) 2007-06-14
EP1519756A2 (fr) 2005-04-06
ATE361103T1 (de) 2007-05-15
RU2005103598A (ru) 2005-11-20
IL165889A0 (en) 2006-01-15
MXPA04012950A (es) 2005-05-16
UA79294C2 (en) 2007-06-11
ZA200501172B (en) 2006-04-26
JP2005532404A (ja) 2005-10-27
WO2004006965A3 (fr) 2004-07-15

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