DK151803C - Analogifremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater eller farmaceutisk acceptable salte deraf - Google Patents
Analogifremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater eller farmaceutisk acceptable salte derafInfo
- Publication number
- DK151803C DK151803C DK400679A DK400679A DK151803C DK 151803 C DK151803 C DK 151803C DK 400679 A DK400679 A DK 400679A DK 400679 A DK400679 A DK 400679A DK 151803 C DK151803 C DK 151803C
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- lower alkyl
- hydrogen
- acceptable salts
- pyrrol
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- PXYUEEJAXOCGBZ-UHFFFAOYSA-N n-(1h-pyrrol-2-yl)pyridazin-3-amine Chemical class C=1C=CN=NC=1NC1=CC=CN1 PXYUEEJAXOCGBZ-UHFFFAOYSA-N 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- FNDJBMQTFVHDPR-UHFFFAOYSA-N 1-[4-[(2,5-dimethylpyrrol-1-yl)amino]phthalazin-1-yl]piperidin-4-ol Chemical compound CC1=CC=C(C)N1NC(C1=CC=CC=C11)=NN=C1N1CCC(O)CC1 FNDJBMQTFVHDPR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 dicarbonyl compound Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7838898 | 1978-10-02 | ||
| GB7838898 | 1978-10-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK400679A DK400679A (da) | 1980-04-03 |
| DK151803B DK151803B (da) | 1988-01-04 |
| DK151803C true DK151803C (da) | 1988-06-13 |
Family
ID=10500040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK400679A DK151803C (da) | 1978-10-02 | 1979-09-25 | Analogifremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater eller farmaceutisk acceptable salte deraf |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0009655B1 (enExample) |
| JP (1) | JPS5569577A (enExample) |
| AT (1) | ATE3294T1 (enExample) |
| AU (1) | AU529482B2 (enExample) |
| CA (1) | CA1144165A (enExample) |
| DE (1) | DE2965377D1 (enExample) |
| DK (1) | DK151803C (enExample) |
| ES (1) | ES484616A1 (enExample) |
| FI (1) | FI65998C (enExample) |
| GR (1) | GR69856B (enExample) |
| IE (1) | IE49017B1 (enExample) |
| IL (1) | IL58256A (enExample) |
| NO (1) | NO151620C (enExample) |
| YU (1) | YU41886B (enExample) |
| ZA (1) | ZA794923B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1150070B (it) * | 1980-12-22 | 1986-12-10 | Lepetit Spa | Procedimento per preparare derivati n-pirrolipiridazinamminici |
| US5254622A (en) * | 1988-12-09 | 1993-10-19 | Asahi Kasei Kogyo Kabushiki Kaisha | ABS resin compositions and molded articles thereof having improved coating performances |
| KR20060037410A (ko) * | 2003-07-30 | 2006-05-03 | 제논 파마슈티칼스 인크. | 피리다진 유도체 및 그의 치료제로서의 용도 |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| EP1804799B1 (en) * | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580856A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| EP1799667B1 (en) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| USD916552S1 (en) * | 2019-07-26 | 2021-04-20 | Spectrum Diversified Designs, Llc | Trivet |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168334A (en) * | 1967-01-25 | 1969-10-22 | Lepetit Spa | New Pharmacologically Active Pyridazines |
| GB1378102A (en) * | 1972-03-14 | 1974-12-18 | Lepetit Spa | Antihypertensive compositions |
| GB1408362A (en) * | 1973-05-25 | 1975-10-01 | Lepetit Spa | 2-pyrrol-1-yl amino 4,5-dihydro-1-h-imidazole derivatives |
| AU477837B2 (en) * | 1973-05-30 | 1974-12-05 | I. S. F. Sp. A | New anti-hypertensive compounds having a high therapeutic index and a long-term hypotensive effect |
| ES431009A1 (es) * | 1974-05-09 | 1976-10-16 | Isf Spa | Procedimiento para la preparacion de derivados de 3-benci- lidenhidracino-6-aminopiridacina. |
-
1979
- 1979-09-07 AT AT79103326T patent/ATE3294T1/de active
- 1979-09-07 EP EP79103326A patent/EP0009655B1/en not_active Expired
- 1979-09-07 DE DE7979103326T patent/DE2965377D1/de not_active Expired
- 1979-09-12 FI FI792832A patent/FI65998C/fi not_active IP Right Cessation
- 1979-09-14 AU AU50866/79A patent/AU529482B2/en not_active Ceased
- 1979-09-17 ZA ZA00794923A patent/ZA794923B/xx unknown
- 1979-09-17 IL IL58256A patent/IL58256A/xx unknown
- 1979-09-24 GR GR60097A patent/GR69856B/el unknown
- 1979-09-25 DK DK400679A patent/DK151803C/da not_active IP Right Cessation
- 1979-09-28 YU YU2374/79A patent/YU41886B/xx unknown
- 1979-10-01 NO NO793151A patent/NO151620C/no unknown
- 1979-10-01 ES ES484616A patent/ES484616A1/es not_active Expired
- 1979-10-01 IE IE1866/79A patent/IE49017B1/en not_active IP Right Cessation
- 1979-10-02 JP JP12647779A patent/JPS5569577A/ja active Granted
- 1979-10-02 CA CA000336843A patent/CA1144165A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI65998B (fi) | 1984-04-30 |
| IL58256A (en) | 1984-02-29 |
| EP0009655B1 (en) | 1983-05-11 |
| YU41886B (en) | 1988-02-29 |
| GR69856B (enExample) | 1982-07-19 |
| FI65998C (fi) | 1984-08-10 |
| ATE3294T1 (de) | 1983-05-15 |
| FI792832A7 (fi) | 1980-04-03 |
| IL58256A0 (en) | 1979-12-30 |
| ZA794923B (en) | 1980-09-24 |
| DE2965377D1 (en) | 1983-06-16 |
| ES484616A1 (es) | 1980-05-16 |
| IE791866L (en) | 1980-04-02 |
| NO151620C (no) | 1985-05-08 |
| NO151620B (no) | 1985-01-28 |
| DK151803B (da) | 1988-01-04 |
| NO793151L (no) | 1980-04-08 |
| YU237479A (en) | 1983-02-28 |
| AU5086679A (en) | 1980-04-17 |
| AU529482B2 (en) | 1983-06-09 |
| JPS5569577A (en) | 1980-05-26 |
| CA1144165A (en) | 1983-04-05 |
| IE49017B1 (en) | 1985-07-10 |
| DK400679A (da) | 1980-04-03 |
| EP0009655A1 (en) | 1980-04-16 |
| JPH0321553B2 (enExample) | 1991-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |