DK1513516T3 - Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser - Google Patents
Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelserInfo
- Publication number
- DK1513516T3 DK1513516T3 DK03736796T DK03736796T DK1513516T3 DK 1513516 T3 DK1513516 T3 DK 1513516T3 DK 03736796 T DK03736796 T DK 03736796T DK 03736796 T DK03736796 T DK 03736796T DK 1513516 T3 DK1513516 T3 DK 1513516T3
- Authority
- DK
- Denmark
- Prior art keywords
- thieno
- pyridine
- amino
- substituted
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/695—Polyesters containing atoms other than carbon, hydrogen and oxygen containing silicon
- C08G63/6954—Polyesters containing atoms other than carbon, hydrogen and oxygen containing silicon derived from polxycarboxylic acids and polyhydroxy compounds
- C08G63/6956—Dicarboxylic acids and dihydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/916—Dicarboxylic acids and dihydroxy compounds
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38631202P | 2002-06-06 | 2002-06-06 | |
US45786703P | 2003-03-26 | 2003-03-26 | |
PCT/US2003/017343 WO2003103661A1 (en) | 2002-06-06 | 2003-06-03 | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1513516T3 true DK1513516T3 (da) | 2009-10-19 |
Family
ID=29739900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03736796T DK1513516T3 (da) | 2002-06-06 | 2003-06-03 | Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser |
Country Status (27)
Country | Link |
---|---|
US (2) | US6964956B2 (zh) |
EP (2) | EP1513516B1 (zh) |
JP (2) | JP4364120B2 (zh) |
KR (1) | KR20050005548A (zh) |
CN (1) | CN100386329C (zh) |
AR (1) | AR040250A1 (zh) |
AT (1) | ATE415966T1 (zh) |
AU (1) | AU2003237330A1 (zh) |
BR (1) | BR0311605A (zh) |
CA (1) | CA2483890C (zh) |
DE (1) | DE60325051D1 (zh) |
DK (1) | DK1513516T3 (zh) |
EA (1) | EA008706B1 (zh) |
ES (1) | ES2318141T3 (zh) |
HK (1) | HK1080737A1 (zh) |
HR (1) | HRP20041154A2 (zh) |
IL (1) | IL164597A0 (zh) |
ME (2) | ME00355B (zh) |
MX (1) | MXPA04011246A (zh) |
NO (1) | NO20044599L (zh) |
NZ (1) | NZ537394A (zh) |
PE (1) | PE20040539A1 (zh) |
PL (1) | PL373424A1 (zh) |
RS (1) | RS105204A (zh) |
TW (1) | TWI296927B (zh) |
UY (1) | UY27834A1 (zh) |
WO (1) | WO2003103661A1 (zh) |
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GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
JP2006512313A (ja) * | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
WO2005012283A1 (en) * | 2003-07-31 | 2005-02-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzothiophene compounds and uses thereof |
US7291733B2 (en) * | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
UY28647A1 (es) * | 2003-12-05 | 2005-07-29 | Boehringer Ingelheim Pharma | Compuestos de amida del ácido 3-amino-tieno(2,3-b)piridin-2-carboxílico sustituido y procedimientos para su preparación y sus usos |
EP1764367A1 (en) * | 2004-04-12 | 2007-03-21 | Sankyo Company, Limited | Thienopyridine derivatives |
CA2563990A1 (en) * | 2004-05-04 | 2005-11-10 | Sharada Shenvi Labadie | Thienopyridazines as ikk inhibitors |
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AU2005244450B2 (en) * | 2004-05-19 | 2010-08-19 | Solvay Pharmaceuticals Gmbh | Medicaments containing N-sulfamoyl-N'-arylpiperazines for the prophylaxis or treatment of obesity and related conditions |
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AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
PE20060748A1 (es) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
ATE476434T1 (de) * | 2004-12-09 | 2010-08-15 | Xention Ltd | Thienopyridinderivate als kaliumkanalinhibitoren |
EP1683799A1 (de) * | 2005-01-12 | 2006-07-26 | IBFB Pharma GmbH | 3-Amino-6aryl(bzw.6-heteroaryl)-4-R²-thieno[2,3-b]pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und deren Verwendung als Inhibitoren der TNFalpha-Freisetzung |
EP1681292A1 (de) * | 2005-01-12 | 2006-07-19 | IBFB Pharma GmbH | 3-Amino-6-aryl(bzw.6-heteroaryl)-thieno¬2,3-b|pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Inhibitoren der TNFalpha-Freisetzung |
WO2006074919A2 (de) * | 2005-01-12 | 2006-07-20 | Curacyte Discovery Gmbh | 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG |
US7465742B2 (en) * | 2005-02-11 | 2008-12-16 | Huanming Chen | Heterocyclic compounds having anti-HBV activity |
JPWO2006129784A1 (ja) * | 2005-06-03 | 2009-01-08 | 独立行政法人理化学研究所 | インターフェロン−α制御剤 |
CN1884262B (zh) * | 2005-06-24 | 2014-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 4-氨基哌啶类化合物及其医药用途 |
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CN101247804B (zh) | 2005-06-30 | 2012-09-26 | 史密丝克莱恩比彻姆公司 | 化学化合物 |
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WO2007102679A1 (en) * | 2006-03-06 | 2007-09-13 | Je Il Pharmaceutical Co., Ltd. | Novel thienopyrimidine derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same |
CA2653654A1 (en) * | 2006-06-06 | 2007-12-21 | Boehringer Ingelheim International Gmbh | Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use |
US20080032409A1 (en) * | 2006-08-07 | 2008-02-07 | California Institute Of Technology | Fluorescent biomolecule labeling reagents |
WO2008020622A1 (fr) * | 2006-08-17 | 2008-02-21 | Kyorin Pharmaceutical Co., Ltd. | NOUVEAU COMPOSÉ DE THIÉNO[2,3-d]PYRIMIDINE |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
CN101684123B (zh) * | 2008-09-27 | 2013-12-11 | 四川大学 | 2-甲酰胺基噻吩并吡啶衍生物制备方法及医药用途 |
WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
US8481547B2 (en) * | 2009-12-18 | 2013-07-09 | Janssen Pharmaceutica Nv | Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1 |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
ES2606637T3 (es) * | 2012-02-09 | 2017-03-24 | Merck Patent Gmbh | Derivados de furo [3,2- b]piridina como inhibidores de TBK1 e IKK |
KR101468207B1 (ko) * | 2013-02-14 | 2014-12-01 | 한국화학연구원 | 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN105829296A (zh) | 2013-12-18 | 2016-08-03 | 巴斯夫欧洲公司 | 带有亚胺衍生的取代基的唑类化合物 |
RU2557550C1 (ru) * | 2014-06-16 | 2015-07-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Антидот гербицида 2,4-дихлорфеноксиуксусной кислоты на подсолнечнике |
US10758522B2 (en) | 2015-06-01 | 2020-09-01 | The Scripps Research Institute | Small molecule analogs of the nemo binding peptide |
KR20180073600A (ko) * | 2015-11-03 | 2018-07-02 | 루 라이센스 에이비 | 과증식성 장애의 치료를 위한 화합물 |
TWI753910B (zh) * | 2016-05-16 | 2022-02-01 | 美商拜歐斯瑞克斯公司 | 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途 |
CN112638382A (zh) * | 2018-06-06 | 2021-04-09 | 国家医疗保健研究所 | 作为epac抑制剂的噻吩并[2,3-b]吡啶衍生物及其药物用途 |
US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
WO2020160537A1 (en) | 2019-02-01 | 2020-08-06 | University Of South Carolina | Bicyclic pyridine compositions and methods of using the same for cancer therapy |
US20220226343A1 (en) * | 2019-05-21 | 2022-07-21 | University Of South Carolina | 3-amino-4-[4-[4 (dimethylcarbamoyl) phenyl]-1,4-diazepan-1-yl]thieno[2,3-b]pyridine-2-carboxamide for use in cancer therapy and formulations comprising the same |
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2003
- 2003-06-03 CA CA2483890A patent/CA2483890C/en not_active Expired - Fee Related
- 2003-06-03 KR KR10-2004-7019850A patent/KR20050005548A/ko not_active Application Discontinuation
- 2003-06-03 NZ NZ537394A patent/NZ537394A/en unknown
- 2003-06-03 AT AT03736796T patent/ATE415966T1/de active
- 2003-06-03 UY UY27834A patent/UY27834A1/es not_active Application Discontinuation
- 2003-06-03 JP JP2004510780A patent/JP4364120B2/ja not_active Expired - Fee Related
- 2003-06-03 MX MXPA04011246A patent/MXPA04011246A/es not_active Application Discontinuation
- 2003-06-03 US US10/453,175 patent/US6964956B2/en not_active Expired - Lifetime
- 2003-06-03 PL PL03373424A patent/PL373424A1/xx not_active Application Discontinuation
- 2003-06-03 ES ES03736796T patent/ES2318141T3/es not_active Expired - Lifetime
- 2003-06-03 BR BR0311605-0A patent/BR0311605A/pt not_active Withdrawn
- 2003-06-03 ME MEP-2008-535A patent/ME00355B/me unknown
- 2003-06-03 EP EP03736796A patent/EP1513516B1/en not_active Expired - Lifetime
- 2003-06-03 ME MEP-535/08A patent/MEP53508A/xx unknown
- 2003-06-03 DK DK03736796T patent/DK1513516T3/da active
- 2003-06-03 EA EA200401541A patent/EA008706B1/ru not_active IP Right Cessation
- 2003-06-03 DE DE60325051T patent/DE60325051D1/de not_active Expired - Lifetime
- 2003-06-03 AU AU2003237330A patent/AU2003237330A1/en not_active Abandoned
- 2003-06-03 EP EP08164478A patent/EP2008654A1/en not_active Withdrawn
- 2003-06-03 WO PCT/US2003/017343 patent/WO2003103661A1/en active Application Filing
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- 2003-06-03 CN CNB038099586A patent/CN100386329C/zh not_active Expired - Fee Related
- 2003-06-04 PE PE2003000560A patent/PE20040539A1/es not_active Application Discontinuation
- 2003-06-05 TW TW092115243A patent/TWI296927B/zh active
- 2003-06-06 AR ARP030102022A patent/AR040250A1/es not_active Suspension/Interruption
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2004
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2005
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2006
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